Procalcitonin and Proinflammatory Cytokine Interactions in Sepsis

Whang, Keven T.; Vath, Steven D.; Becker, Kenneth L.; Snider, Richard H.; Nylen, Eric; Müller, Beat; Li, Qichang; Tamarkin, Lawrence; White, Jon

doi:10.1097/00024382-200014010-00013

Cited by 104 publications

(59 citation statements)

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“…The temporal release patterns of the inflammatory markers showed large differences in time to peak values with an early cellular cytokine response, whereas the organ derived inflammatory markers PCT and CRP were more slowly released over the following days as a response of pro-inflammatory stimuli. 28,29 Our data clearly demonstrate that level of IL-6 and other key mediators of the pro-and anti-inflammatory response were not influenced by TTM at 33 • C compared to 36 • C. This is in contrast to previous findings, where hypothermia significantly altered the level of IL-6, CRP and PCT compared to patients not treated with active temperature control. 11 However, this study had several limitations including being a non-randomized study with possible selection of patients treated with hypothermia.…”

Section: Discussioncontrasting

confidence: 63%

The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C

et al. 2014

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Section: Discussioncontrasting

confidence: 63%

The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C

et al. 2014

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“…In a recent report by Whang et al [15] PCT given to healthy or septic hamsters did not significantly influence the levels of the proinflammatory cytokines interleukin 1b and tumour necrosis factor a. These observations are consistent with ours, and suggest that PCT is not a modulator of the primary response to infection.…”

Section: Discussionsupporting

confidence: 91%

Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes

et al. 2001

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The plasma levels of procalcitonin (PCT) are increased in patients with severe bacterial infections. Its cellular origin and potential pathophysiological function in sepsis is, however, unclear. White blood cells have recently been described to express both PCT mRNA and protein. The aim of this study was to determine whether PCT has any influence on the surface expression of receptors, relevant in inflammation, on human whole blood leukocytes under normal and septic conditions. Venous blood from healthy donors was incubated with PCT (40 ng/ml or 1200 ng/ml) alone or in combination with lipopolysaccharide (LPS, 10 ng/ml) or peptidoglycan (PepG, 10 micrograms/ml) for 6 h. The surface expression of CD14, CD54, CD64, CD80, CD86 and HLA-DR was determined by flow cytometry. We could not detect any influence of PCT on the expression of these receptors. Further studies on potential effects on other cell types during infection seem warranted.

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“…inverser Korrelation von IL-6 und PCT bei nichtinfektiösen Affektionen oder langen Verläufen einer Sepsis nicht generell annehmen [29]. Ebenso konnten Redl et al [31] im Gegensatz zu anderen Autoren [5,35] von PCT in der Sepsis im Tiermodell nicht bestätigen.In-vitro und In-vivo-Untersuchungen beim Menschen konnten jedoch zeigen, dass die PCT-Synthese durch Zytokine, wie TNF-α und IL-6, gesteigert werden kann und PCT sich wie ein Akutphaseprotein vergleichbar dem CRP verhält [25]. Darüber hinaus konnte in vitro eine substanzielle Synthese von PCT im Lebergewebe des Menschen belegt werden [25].…”

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Procalcitoninplasmakonzentration und systemische inflammatorische Antwort nach verschiedenen operativen Eingriffen

et al. 2003

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Postoperative PCT plasma concentrations in patients presenting without signs of infection are largely influenced by the type of surgical procedure. During the first and second postoperative day PCT concentrations are more frequently elevated in patients after major abdominal, major vascular and thoracic surgery compared to patients undergoing minor, aseptic operations. Thus an "infection monitoring" considering PCT value analysis during the postoperative course may transiently be impeded after major and particularly after intestinal surgery during the first 2 days postoperatively, whereas it appears not to be substantially affected by the presence or absence of systemic inflammatory response.

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Procalcitonin and Proinflammatory Cytokine Interactions in Sepsis

Cited by 104 publications

References 0 publications

The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C

The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C

Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes

Procalcitoninplasmakonzentration und systemische inflammatorische Antwort nach verschiedenen operativen Eingriffen

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