Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient?

Giamarellos‐Bourboulis, Evangelos J.; Mega, Anna; Grecka, P.; Scarpa, Nektaria; Koratzanis, George; Thomopoulos, George N.; Giamarellou, Helen

doi:10.1007/s00134-002-1398-z

Cited by 135 publications

(65 citation statements)

References 20 publications

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“…16,17 Moreover, many critically ill patients progressing to ARDS had serum procalcitonin levels Ն 10.0 ng/mL. 19 Similarly, the present study revealed that subjects with semi-quantitative serum procalcitonin levels Ն 10.0 ng/mL required intensive care, including vasopressor administration or mechanical ventilation, more frequently than those with levels of Ͻ 10.0 ng/mL. However, over one half of the subjects who required intensive care had semi-quantitative serum procalcitonin levels of Ͻ 10.0 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

Predictive Values of Semi-Quantitative Procalcitonin Test and Common Biomarkers for the Clinical Outcomes of Community-Acquired Pneumonia

Ugajin¹,

Yamaki²,

Hirasawa³

et al. 2013

Respir Care

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BACKGROUND:The semi-quantitative serum procalcitonin test (Brahms PCT-Q) is available conveniently in clinical practice. However, there are few data on the relationship between results for this semi-quantitative procalcitonin test and clinical outcomes of community-acquired pneumonia (CAP). We investigated the usefulness of this procalcitonin test for predicting the clinical outcomes of CAP in comparison with severity scoring systems and the blood urea nitrogen/serum albumin (B/A) ratio, which has been reported to be a simple but reliable prognostic indicator in our prior CAP study. METHODS: This retrospective study included data from subjects who were hospitalized for CAP from August 2010 through October 2012 and who were administered the semiquantitative serum procalcitonin test on admission. The demographic characteristics; laboratory biomarkers; microbiological test results; Pneumonia Severity Index scores; confusion, urea nitrogen, breathing frequency, blood pressure, > 65 years of age (CURB-65) scale scores; and age, dehydration, respiratory failure, orientation disturbance, pressure (A-DROP) scale scores on hospital admission were retrieved from their medical charts. The outcomes were mortality within 28 days of hospital admission and the need for intensive care. RESULTS: Of the 213 subjects with CAP who were enrolled in the study, 20 died within 28 days of hospital admission, and 32 required intensive care. Mortality did not differ significantly among subjects with different semi-quantitative serum procalcitonin levels; however, subjects with serum procalcitonin levels > 10.0 ng/mL were more likely to require intensive care than those with lower levels (P < .001). The elevation of semi-quantitative serum procalcitonin levels was more frequently observed in subjects with proven etiology, especially pneumococcal pneumonia. Using the receiver operating characteristic curves for mortality, the area under the curve was 0.86 for Pneumonia Severity Index class, 0.81 for B/A ratio, 0.81 for A-DROP, 0.80 for CURB-65, and 0.57 for semi-quantitative procalcitonin test. CONCLU-SIONS: The semi-quantitative serum procalcitonin level on hospital admission was less predictive of mortality from CAP compared with the B/A ratio. However, the subjects with serum procalcitonin levels > 10.0 ng/mL were more likely to require intensive care than those with lower levels.

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Section: Discussionmentioning

confidence: 99%

Predictive Values of Semi-Quantitative Procalcitonin Test and Common Biomarkers for the Clinical Outcomes of Community-Acquired Pneumonia

Ugajin¹,

Yamaki²,

Hirasawa³

et al. 2013

Respir Care

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“…Regarding the prognostic role, studies showed that only one measurement of serum PCT at the onset of sepsis is not enough for predicting outcome, repeated measurements of serum values PCT being necessary. (14,15) A prospective study performed on 472 critically ill patients demonstrated that an increasing PCT value with >1.0 ng/mL after first reading is an independent predictor of mortality within 90 days and that mortality increased every day that PCT increased. (16) Another study showed that serum PCT values measured in day 2 after hospital admission discriminated between survivors and non-survivor patients with sepsis.…”

Section: Discussionmentioning

confidence: 99%

Can we find accessible and relevant markers for sepsis outcome?

Cioara

Flonta

Binder

et al. 2017

Revista Romana De Medicina De Laborator

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“…40 PCT was also found to be a predictor of mortality in a study involving 472 critical care patients. 41 PCT measurement was done daily in these patients and both high PCT levels and the increase in the levels following the first reading of greater then 1.0 ng/mL were independent predictors of 90 day mortality.…”

Section: Procalcitonin As a Prognostic Marker Of Bacterial Infectionsmentioning

confidence: 90%

Procalcitonin in sepsis and bacterial infections

Chaudhury¹,

Sumant²,

Jayaprada³

et al. 2013

JCSR

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The differentiation of sepsis and systemic bacterial infections from other causes of systemic inflammatory response is crucial from the therapeutic point of view. The clinical signs and symptoms are non-specific and traditional biomarkers like white cell count, erythrocyte sedimentation rate and C-reactive protein are not sufficiently sensitive or specific to guide therapeutic decisions. Procalcitonin (PCT) is considered a reliable marker for the diagnosis and prognosis of moderate to severe bacterial infections, and it has also been evaluated to guide the clinicians in the rational usage of antibiotics. This review describes the diagnostic and prognostic role of PCT as a biomarker in various clinical settings along with the laboratory aspects and its usefulness in risk stratification and antibiotic stewardship.

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Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient?

Cited by 135 publications

References 20 publications

Predictive Values of Semi-Quantitative Procalcitonin Test and Common Biomarkers for the Clinical Outcomes of Community-Acquired Pneumonia

Predictive Values of Semi-Quantitative Procalcitonin Test and Common Biomarkers for the Clinical Outcomes of Community-Acquired Pneumonia

Can we find accessible and relevant markers for sepsis outcome?

Procalcitonin in sepsis and bacterial infections

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