Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs

Li, Yue; Sheng, Li; Li, Weimin; Liu, Wei; Gong, Yanling; Xue, Hong-Jie; Shan, Hongbo

doi:10.1016/j.bbrc.2009.02.007

Cited by 20 publications

(16 citation statements)

References 23 publications

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“…In addition, probucol effectively inhibited atrial nerve growth factor-beta upregulation, attenuated atrial nerve sprouting and heterogeneous sympathetic hyperinnervation, and reduced the inducibility and duration of AF [86]. In another experimental study, probucol effectively attenuated atrial structural remodeling and apoptosis [87]. Moreover, Fu et al investigated the effects of probucol on atrial structural and electrical remodeling in alloxan-induced diabetic rabbits demonstrating that probucol significantly reduces left atrial interstitial fibrosis and AF inducibility [88].…”

Section: Upstream Therapies For Diabetes Mellitus Related Atrial Remomentioning

confidence: 97%

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Goudis¹,

Korantzopoulos

Ntalas

et al. 2015

International Journal of Cardiology

114

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Section: Upstream Therapies For Diabetes Mellitus Related Atrial Remomentioning

confidence: 97%

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Goudis¹,

Korantzopoulos

Ntalas

et al. 2015

International Journal of Cardiology

114

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“…Also, probucol significantly reduces atrial oxidative stress and increases total antioxidant capacity [55]. A further study from this group suggested that probucol attenuates structural remodeling and preventes atrial apoptosis, decreasing the left atrial MDA content in paced dogs [56]. Very recently, we investigated the effects of probucol on atrial structural and electrical remodeling in alloxaninduced diabetic rabbits [57].…”

Section: Probucolmentioning

confidence: 99%

Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Liu¹,

Korantzopoulos²,

Li³

2013

Atrial Fibrillation - Mechanisms and Treatment

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“…26 It has also been reported that pretreatment with probucol attenuates cardiomyocyte apoptosis induced by adriamycin 27 and in heart failure rat model 28 and atrial apoptosis in prolonged pacing-induced atrial fibrillation dogs. 29 Research by Wang et al 30 discovered that probucol protects the renal microvascular endothelial cells from advanced glycation end product-induced damage, but its protective effect against apoptosis in renal tubular epithelial cells has not been shown so far in any published document. On the basis of the aforementioned similarities, we hypothesized that PGE1 and probucol might have protective effects on MG-induced apoptosis in renal proximal tubular cells.…”

Section: Introductionmentioning

confidence: 99%

Methylguanidine cytotoxicity on HK-2 cells and protective effect of antioxidants against MG-induced apoptosis in renal proximal tubular cellsin vitro

et al. 2010

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The present study was designed to explore the toxic effect of MG on renal proximal tubular cells as well as the protective effect of antioxidants PGE1 and probucol against MG-induced apoptosis in renal proximal tubular cells. HK-2 cells were used as the subject. The cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. N-Acetyl-3-D-glucosaminidase (NAG) activity, malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity were determined. Cell apoptosis was determined by flow cytometry (light scatter and propidium iodide/annexin V-FTC fluorescence) and by nuclear staining with Hoechst 33258. Cells were exposed to MG (0.25, 0.5, or 1 mmol/L), MG (0.5 mmol/L) + PGE1 (2 μg/L), and MG (0.5 mmol/L) + probucol (20 μmol/L) respectively for 24 h. MG induced a significant dose-dependent loss of cell viability. Both PGE1 and probucol improved the viability of MG-treated HK-2 cells. Cells showed apoptotic morphology (deepened stain, karyopyknosis, and apoptotic body) when exposed to 0.5 mmol/L MG for 24 h, and the apoptosis ratio was increased compared with the control. The presence of PGE1 or probucol significantly lowered the apoptotic ratio. Moreover, PGE1 or probucol notably decreased the MDA content and increased the SOD activity compared with when the cells were treated with MG only. The results of the present study clearly demonstrate that MG could promote apoptosis of renal proximal tubular cells in vitro. Both PGE1 and probucol could protect renal proximal tubular cells from MG-induced apoptosis.

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Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs

Cited by 20 publications

References 23 publications

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Methylguanidine cytotoxicity on HK-2 cells and protective effect of antioxidants against MG-induced apoptosis in renal proximal tubular cellsin vitro

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