Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Liu, Tong; Korantzopoulos, Panagiotis; Li, Guangping

doi:10.5772/53408

Cited by 11 publications

(18 citation statements)

References 87 publications

(86 reference statements)

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“…The mechanism of AF is complicate and not fully understood. In recent years, inflammation, oxidative stress, and atrial fibrosis have been demonstrated to play important role in initiation and maintenance of AF [3][4][5][6][7][8]. The present study explored the possible mechanism of protective effects of EGCG in these three aspects.…”

Section: Discussionmentioning

confidence: 90%

“…Accumulating evidence suggests oxidative stress may play an important role in the pathogenesis and perpetuation of AF [7,8]. Myocardial NADPH oxidase, NO synthases (NOSs), and mitochondrial oxidases contribute significantly to superoxide production in AF [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…Myocardial NADPH oxidase, NO synthases (NOSs), and mitochondrial oxidases contribute significantly to superoxide production in AF [17,18]. In recent years, plenty of clinical and experimental evidence have supported the concept of antioxidant interventions to prevent AF [7,8]. Several interventions with antioxidant properties such as statins, ACE-inhibitors (ACEIs), angiotensinreceptor blockers (ARBs), omega-3 polyunsaturated fatty acids, and Vitamin C and E have been tested as novel strategies in the prevention and treatment of AF [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, an increasing body of evidence supports the role of inflammation, oxidant stress, and atrial fibrosis in the initiation, maintenance, and perpetuation of AF [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Zhu

Xiao

et al. 2014

Cell Biochem Biophys

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Epigallocatechin-3 gallate (EGCG) is the major catechin in green tea. The aim of this study is to investigate the effects of EGCG on atrial electrical and structural remodeling in a rabbit rapid atrial pacing (RAP) model. New Zealand white rabbits were subjected to RAP with or without EGCG treatment. The atrial electrophysiology was studied. ELISA, Western blots, and RT-PCR were performed to determine the level of the inflammation markers, oxidative stress, and fibrogenic agents. Atrial tissue was stained with Masson's trichrome stain for fibrosis detection. RAP rabbits showed a significantly shorter atrial effective refractory period than control rabbits. Higher AF inducibility and longer AF duration were seen in the RAP group. AERP of rabbits received high dose EGCG were prolonged compared to RAP rabbits, and AF inducibility and duration of rabbits received high dose EGCG were lower. RAP rabbits have higher inflammation markers, higher oxidative stress, and more significant fibrosis within atrium, while high dose intervention of EGCG can lower the inflammation, oxidative stress, and fibrosis induced by RAP. Results showed that EGCG have protective effects on atrial electrical and structural remodeling in a rabbit RAP model in terms of attenuating of inflammation and oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Recently, an increasing body of evidence supports the role of inflammation, oxidant stress, and atrial fibrosis in the initiation, maintenance, and perpetuation of AF [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Zhu

Xiao

et al. 2014

Cell Biochem Biophys

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“…The mechanisms underlying both the initiation and perpetuation of AF are not well established but are thought to involve inflammation and oxidative stress [6][7][8]. Recently oxidative stress has been linked with atrial fibrillation [9]. There is evidence for enhanced oxidative stress in atrial tissue samples from AF patients [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Resveratrol on Oxidative Stress Injury Induced by Rapid-Pacing in Isolated Rabbit Hearts

W¹

2014

J Dev Drugs

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Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practice

Tadić

Cuspidi

2015

Archives of Cardiovascular Diseases

110

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Type 2 diabetes mellitus is one of the most common chronic conditions and its prevalence has increased continuously over the past decades, primarily due to the obesity epidemic. Atrial fibrillation (AF) is the most frequent sustained cardiac arrhythmia in clinical practice and is associated with increased cardiovascular and cerebrovascular morbidity and mortality. Recent studies have shown that patients with diabetes have an increased risk of AF. However, the results about the relationship between diabetes and AF are still conflicting. Mechanisms that are responsible for an association between diabetes and AF, as well as the adequate treatment of AF in patients with diabetes, are still insufficiently studied. The aim of this review is to summarize the current knowledge of mechanisms that connect AF and diabetes, the clinical studies that include patients with both conditions, and the treatment options in modern pharmacology.

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Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Cited by 11 publications

References 87 publications

Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Protective Effects of Epigallocatechin-3 Gallate on Atrial Electrical and Structural Remodeling in a Rabbit Rapid Atrial Pacing Model

Effects of Resveratrol on Oxidative Stress Injury Induced by Rapid-Pacing in Isolated Rabbit Hearts

Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practice

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