Problems associated with prophylactic use of erythromycin in 1566 staff to prevent hospital infection during the outbreak of pertussis

Tanaka, Hiroaki; Kaji, Masahiro; Higuchi, Kazuko; Shinohara, Naohide; Norimatsu, Mari; Kawazoe, Hitoshi; Ninomiya, Motoki; Fukuoka, Noriyasu; Ishii, Noriko; Fujita, Jiro; Okabe, Akihiro

doi:10.1111/j.1365-2710.2009.01060.x

Cited by 6 publications

(2 citation statements)

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“…In Japan, prophylactic administration of erythromycin caused adverse effects such as digestive organ symptoms, diarrhea, stomachache and abdominal distention in hospital staffs in 2009. It suggested that attention should be paid to erythromycin compliance during a pertussis outbreak (25). …”

Section: Discussionmentioning

confidence: 99%

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

Shahcheraghi

Lotfi

Nikbin

et al. 2014

Jundishapur J Microbiol

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Background:Whooping cough was considered as one of the major causes of childhood morbidity and mortality worldwide. Resistant isolates of Bordetella pertussis to macrolides in some countries have been recently reported.Objectives:Recent reports on macrolide-resistant B. pertussis isolates and lack of evidence for such resistance in clinical isolates of the Iranian patients led the authors of the current study to study antibiotic susceptibility of the collected isolates in the country. Susceptibility of the B. pertussis isolates to three antibiotics was studied. Relatedness of the strains recovered in this research was also examined.Materials and Methods:The antibacterial activities of erythromycin, azithromycin, and clarithromycin antibiotics against the recovered isolates of 779 nasopharyngeal swabs were examined using MIC (Minimum Inhibitory Concentration) method. Relationship of the strains was characterized by Pulsed-field Gel Electrophoresis (PFGE).Results:Among the specimens, 11 cases (1.4%) were culture-positive. Among these isolates, only two isolates had high MIC values for erythromycin and clarithromycin. Pulsed-field gel electrophoresis analysis of the isolates revealed 6 PFGE profiles (A-F) among which three and two isolates had the same patterns in profiles A and B, respectively.Conclusions:Azithromycin can be a good drug of choice to treat patients infected by B. pertussis in Iran. Clonal relationship of the isolates showed that the same B. pertussis strains were isolated from different patients in Iran.

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Section: Discussionmentioning

confidence: 99%

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

Shahcheraghi

Lotfi

Nikbin

et al. 2014

Jundishapur J Microbiol

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“…While studies have demonstrated the effectiveness of PEP at preventing secondary transmission of pertussis [14][15][16][17][18], available data have focused primarily on erythromycin which, compared to the newer macrolide azithromycin, is less commonly used because it requires a longer treatment course and has a less favorable side effect profile, resulting in lower compliance [19][20][21][22]. It is also unclear whether PEP is needed in the setting of pertussis vaccination, despite waning vaccine-induced immunity [18].…”

Section: Introductionmentioning

confidence: 99%

High post-exposure prophylaxis (PEP) uptake among household contacts of pertussis patients enrolled in a PEP effectiveness evaluation – United States, 2015–2017

McNamara,

Rubis,

Pawloski

et al. 2023

PLoS ONE

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Background Post-exposure prophylaxis (PEP) for pertussis is recommended for household contacts of pertussis cases in the United States within 21 days of exposure, but data on PEP effectiveness for prevention of secondary cases in the setting of widespread pertussis vaccination are limited. We implemented a multi-state evaluation of azithromycin PEP use and effectiveness among household contacts. Methods Culture- or PCR-confirmed pertussis cases were identified through surveillance. Household contacts were interviewed within 7 days of case report and again 14–21 days later. Interviewers collected information on exposure, demographics, vaccine history, prior pertussis diagnosis, underlying conditions, PEP receipt, pertussis symptoms, and pertussis testing. A subset of household contacts provided nasopharyngeal and blood specimens during interviews. Results Of 299 household contacts who completed both interviews, 12 (4%) reported not receiving PEP. There was no evidence of higher prevalence of cough or pertussis symptoms among contacts who did not receive PEP. Of 168 household contacts who provided at least one nasopharyngeal specimen, four (2.4%) were culture or PCR positive for B. pertussis; three of these received PEP prior to their positive test result. Of 156 contacts with serologic results, 14 (9%) had blood specimens that were positive for IgG anti-pertussis toxin (PT) antibodies; all had received PEP. Conclusions Very high PEP uptake was observed among household contacts of pertussis patients. Although the number of contacts who did not receive PEP was small, there was no difference in prevalence of pertussis symptoms or positive laboratory results among these contacts compared with those who did receive PEP.

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Vaccines for Healthcare Personnel

Weber¹,

Rutala²

2018

Plotkin's Vaccines

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Problems associated with prophylactic use of erythromycin in 1566 staff to prevent hospital infection during the outbreak of pertussis

Cited by 6 publications

References 7 publications

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

The First Macrolide-Resistant Bordetella pertussis Strains Isolated From Iranian Patients

High post-exposure prophylaxis (PEP) uptake among household contacts of pertussis patients enrolled in a PEP effectiveness evaluation – United States, 2015–2017

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