Problematic molecular diagnosis of HSV-1 infection due to a single nucleotide polymorphism in the US7 gene

Vitale, Sébastien; Loubatier, Céline; Cannavo, Isabelle; Giordanengo, Valérie

doi:10.1016/j.jcv.2018.12.001

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Herpes Simplex Virus (HSV) infection is a worldwide cause of severe medical conditions such as encephalitis, keratitis, and neonatal herpes [94,95]. It has two serotypes, HSV-1 and HSV-2, which primarily infect individuals through epithelial cells.…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways

Zheng

Zhang

et al. 2020

Virol J

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Background In the past decades, researchers have demonstrated the critical role of Toll-like receptors (TLRs) in the innate immune system. They recognize viral components and trigger immune signal cascades to subsequently promote the activation of the immune system. Main body Herpesviridae family members trigger TLRs to elicit cytokines in the process of infection to activate antiviral innate immune responses in host cells. This review aims to clarify the role of TLRs in the innate immunity defense against herpesviridae, and systematically describes the processes of TLR actions and herpesviridae recognition as well as the signal transduction pathways involved. Conclusions Future studies of the interactions between TLRs and herpesviridae infections, especially the subsequent signaling pathways, will not only contribute to the planning of effective antiviral therapies but also provide new molecular targets for the development of antiviral drugs.

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Section: Herpes Simplex Virusmentioning

confidence: 99%