Problem of Cancer in Ulcerative Colitis

McMillan, W. Owen; Jt, Garbutt; Jm, Ruffin

doi:10.1097/00007611-196805000-00019

Cited by 6 publications

(2 citation statements)

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“… 1-150 References7 81 94-96 99 101-108 110 113-117 120-122 124 127 128 132 133 135-138 140 142 143 145 148 150 155 157 159 161 163 165 167 170-173 176 177 180–182 185–189 191–205 1-151 References93 98 100 109 112 123 126 134 141 146 147 149 151-154 158 160 162 166 168 169 175 ‡ References10 97 111 118 119 125 129-131 139 144 156 164 174 178 179 183 184 190 …”

Section: Resultsmentioning

confidence: 99%

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The risk of colorectal cancer in ulcerative colitis: a meta-analysis

Eaden

Abrams

Mayberry

2001

Gut

2,559

1,706

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Background and aims-Controversy surrounds the risk of colorectal cancer (CRC) in ulcerative colitis (UC). Many studies have investigated this risk and reported widely varying rates. Methods-A literature search using Medline with the explosion of references identified 194 studies. Of these, 116 met our inclusion criteria from which the number of patients and cancers detected could be extracted. Overall pooled estimates, with 95% confidence intervals (CI), of cancer prevalence and incidence were obtained using a random eVects model on either the log odds or log incidence scale, as appropriate. Results-The overall prevalence of CRC in any UC patient, based on 116 studies, was estimated to be 3.7% (95% CI 3.2-4.2%). Of the 116 studies, 41 reported colitis duration. From these the overall incidence rate was 3/1000 person years duration (pyd), (95% CI 2/1000 to 4/1000). The overall incidence rate for any child was 6/1000 pyd (95% CI 3/1000 to 13/1000). Of the 41 studies, 19 reported results stratified into 10 year intervals of disease duration. For the first 10 years the incidence rate was 2/1000 pyd (95% CI 1/1000 to 2/1000), for the second decade the incidence rate was estimated to be 7/1000 pyd (95% CI 4/1000 to 12/1000), and in the third decade the incidence rate was 12/1000 pyd (95% CI 7/1000 to 19/1000). These incidence rates corresponded to cumulative probabilities of 2% by 10 years, 8% by 20 years, and 18% by 30 years. The worldwide cancer incidence rates varied geographically, being 5/1000 pyd in the USA, 4/1000 pyd in the UK, and 2/1000 pyd in Scandinavia and other countries. Over time the cancer risk has increased since 1955 but this finding was not significant (p=0.8). Conclusions-Using new meta-analysis techniques we determined the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children. We found a non-significant increase in risk over time and estimated how risk varies with geography. (Gut 2001;48:526-535)

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Section: Resultsmentioning

confidence: 99%

“…1-150 References7 81 94-96 99 101-108 110 113-117 120-122 124 127 128 132 133 135-138 140 142 143 145 148 150 155 157 159 161 163 165 167 170-173 176 177 180–182 185–189 191–205 …”

Section: Resultsmentioning

confidence: 99%