Probiotics Treatment of Leg Diseases in Broiler Chickens: a Review

Effects of Probiotics and Gut Microbiota on Bone Metabolism in Chickens: A Review

“…The variation in the gut microbiota caused by antibiotics, pesticides, and other factors may reduce intestinal barrier function, thus affecting bone health [ 12 , 23 , 24 ]. The difference in gut microbiota between TD and healthy chickens was revealed using a high-throughput sequencing technology [ 25 ].…”

“…Previous studies have mainly focused on the effects of probiotics on poultry production performance, egg, and meat quality, intestinal health, and anti-stress phenomena ( Figure 1 ) [ 29 , 30 ]. Recent studies have confirmed that probiotics also play an important role in maintaining bone health [ 17 , 24 , 28 , 31 , 32 ]. Supplementation with probiotics can regulate intestinal microbiota homeostasis and has broad application prospects in the prevention and treatment of bone disease [ 24 , 33 , 34 ].…”

“…Recent studies have confirmed that probiotics also play an important role in maintaining bone health [ 17 , 24 , 28 , 31 , 32 ]. Supplementation with probiotics can regulate intestinal microbiota homeostasis and has broad application prospects in the prevention and treatment of bone disease [ 24 , 33 , 34 ]. This review illuminates the mechanism of the probiotics that regulate bone metabolism through the gut microbiota to provide a theoretical basis for bone-related studies in broiler chickens.…”

Integrated Fecal Microbiome and Metabolomics Reveals a Novel Potential Biomarker for Predicting Tibial Dyschondroplasia in Chickens

“…Tibial dyschondroplasia (TD) is a metabolic cartilage disease that can occur in humans or animals, including poultry, especially broilers and turkeys, accompanied by a rapid growth rate ( Poulos, 1978 ; Leach and Monsonego-Ornan, 2007 ; Xu et al, 2021 ). It is characterized by an abnormality in the bone growth plate.…”

“…Although 16S rRNA gene sequencing technology has been successfully applied in clinical diagnosis, the phylogenetic resolution of the 16S rRNA gene is limited that restricts the universality and significance of these studies ( Rodriguez-R et al, 2018 ; Zhu et al, 2021 ). The gut metabolome, rather than the gut microbiota itself, may also directly involve TD formation ( He et al, 2020 ; Lu et al, 2021 ; Xu et al, 2021 ). Furthermore, fecal metabolomics is derived not only from microbial metabolism that accounts for 15%, but also jointly from diet and host metabolism ( HolmesLi et al, 2012 ; Kim et al, 2020 ; Murga-Garrido et al, 2021 ), which provides a complementary functional readout of microbial activity, and combining these two omics-approaches is a mature strategy for identifying potentially disease-related gut microbes and their functional metabolites ( Klein et al, 2016 ; Stewart et al, 2017 ).…”