Probiotics of Diverse Origin and Their Therapeutic Applications: A Review

Yadav, Monika; Mandeep,; Shukla, Pratyoosh

doi:10.1080/07315724.2019.1691957

Cited by 28 publications

(22 citation statements)

References 100 publications

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“…Most E. coli are benign commensals, but some are opportunistic pathogens. E. coli Nissle 1971 (EcN) is the best known E. coli probiotic [35,36]. Nissle bacteria are protected from stomach acid by added enteric coating.…”

Section: Types Of Probiotic Microbesmentioning

confidence: 99%

“…There is strong evidence that some bacterial strains are efficient in enhancing immune function. Probiotics are also beneficial in mental disorders and reduce carcinogenic activity, cholesterol level, and blood pressure [35]. The significance of probiotics in preventing traveler's diarrhea, sepsis-associated with severe pancreatitis, ulcerative colitis, and reduction of hyper cholesterol is unproven [89,90].…”

Section: Application Of Probiotics In Clinical Usementioning

confidence: 99%

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Probiotic: An Uprising Human Health Concept

Bhatt¹,

Kothari²,

Kothari³

et al. 2022

Prebiotics and Probiotics - From Food to Health

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Most of our gut microbiota live with us in a mutually beneficial life-long relationship. The gut microbiota plays a vital role in the host’s overall health through its metabolic activities. Human microbiota might be supported by consuming friendly bacteria (probiotics) and consuming foods to improve the microbiota (prebiotics). During the last two decades, probiotics’ interest has increased with rising scientific shreds of evidence of benefits on human health. Hence, they have been exploited as various food products, mainly fermented foods. Probiotics as a treatment modality may restore normal microbiota and functioning of the gastrointestinal (GI) tract. Strong scientific evidence is associating these bacteria with the prevention and therapy of various GI disorders. (In light of the ongoing trend of probiotics, further research is needed to obtain the perspective of potential applications for better health. Probiotic applications have been extended from health applications to food and agricultural applications. The benefits of probiotics led to its applications in probiotic ‘health food’ industries and agricultural sectors.

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Section: Types Of Probiotic Microbesmentioning

confidence: 99%

Section: Application Of Probiotics In Clinical Usementioning

confidence: 99%

Probiotic: An Uprising Human Health Concept

Bhatt¹,

Kothari²,

Kothari³

et al. 2022

Prebiotics and Probiotics - From Food to Health

View full text Add to dashboard Cite

show abstract

“…Probiotics ( Table 3 ) can inhibit the proliferation of cancer cells, delaying the generation of tumors and preventing deleterious adverse effects linked with cancer treatment [ 61 ]. The anticancer activity of probiotics involves various mechanisms, including modulation of the immune system, apoptosis, antioxidant activity, epigenetic mechanism, and DNA damage prevention [ 62 ]. Probiotics (e.g., Bifidobacterium and L. acidophilus ) have the ability to decrease the formation of β-glucuronidase and nitroreductase, providing a very efficient mechanism aimed at preventing conversion of procarcinogens into carcinogens.…”

Section: The Possible Role Of Probiotics In Mitigation and Regulation Of Cancermentioning

confidence: 99%

Novel Insights into the Role of Probiotics in Respiratory Infections, Allergies, Cancer, and Neurological Abnormalities

et al. 2021

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In recent years, probiotics have attracted public attention and transformed the social perception of microorganisms, convening a beneficial role/state on human health. With aging, the immune system, body physiology, and intestinal microbiota tend to change unfavorably, resulting in many chronic conditions. The immune-mediated disorders can be linked to intestinal dysbiosis, consequently leading to immune dysfunctions and a cluster of conditions such as asthma, autoimmune diseases, eczema, and various allergies. Probiotic bacteria such as Lactobacillus and Bifidobacterium species are considered probiotic species that have a great immunomodulatory and anti-allergic effect. Moreover, recent scientific and clinical data illustrate that probiotics can regulate the immune system, exert anti-viral and anti-tumoral activity, and shields the host against oxidative stress. Additionally, microbiota programming by probiotic bacteria can reduce and prevent the symptoms of respiratory infections and ameliorate the neurological status in humans. This review describes the most recent clinical findings, including safe probiotic therapies aiming to medicate respiratory infections, allergies, cancer, and neurological disorders due to their physiological interconnection. Subsequently, we will describe the major biological mechanism by which probiotic bacteriotherapy expresses its anti-viral, anti-allergic, anticancer, and neuro-stimulatory effects.

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“…Interestingly, 3-HPA concentrations of 15-30 μg per ml were shown to inhibit the growth of Gram-negative and Grampositive bacteria, yeasts, fungi, and protozoa in vitro (Casas and Dobrogosz, 2000). The probiotic effect of lactobacilli has been tested in a variety of in vivo experiments yielding beneficial results in various diseases (Yadav et al, 2020). However, the majority of these studies have focused on the effects of supplementation of bacteria as probiotic and not on the effect of the reuterin system.…”

Section: Introductionmentioning

confidence: 99%

Production, Storage Stability, and Susceptibility Testing of Reuterin and Its Impact on the Murine Fecal Microbiome and Volatile Organic Compound Profile

et al. 2021

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Background: Probiotics are generally considered as safe, but infections may rarely occur in vulnerable patients. Alternatives to live microorganisms to manage dysbiosis may be of interest in these patients. Reuterin is a complex component system exhibiting broad spectrum antimicrobial activity and a possible candidate substance in these cases.Methods: Reuterin supernatant was cultured from Lentilactobacillus diolivorans in a bioreactor in a two-step process. Storage stability at −20°C and effect of repeated freeze-thaw cycles were assessed by high performance liquid chromatography (HPLC). Antimicrobial activity was tested against Clostridium difficile, Listeria monocytogenes, Escherichia coli, Enterococcus faecium, Staphylococcus (S.) aureus, Staphylococcus epidermidis, Streptococcus (S.) agalactiae, Propionibacterium acnes, and Pseudomonas aeruginosae. Male BALBc mice were gavage fed with reuterin supernatant (n = 10) or culture medium (n = 10). Fecal volatile organic compounds (VOC) were assessed by gas chromatography mass spectroscopy; the microbiome was examined by 16S rRNA gene sequencing.Results: The supernatant contained 13.4 g/L reuterin (3-hydroxypropionaldehyde; 3-HPA). 3-HPA content remained stable at −20°C for 35 days followed by a slow decrease of its concentration. Repeated freezing/thawing caused a slow 3-HPA decrease. Antimicrobial activity was encountered against S. aureus, S. epidermidis, and S. agalactiae. Microbiome analysis showed no differences in alpha and beta diversity markers. Linear discriminant effect size (LEfSe) analysis identified Lachnospiraceae_bacterium_COE1 and Ruminoclostridium_5_uncultured_Clostridiales_ bacterium (in the reuterin medium group) and Desulfovibrio_uncultured_ bacterium, Candidatus Arthromitus, Ruminococcae_NK4A214_group, and Eubacterium_xylanophilum_group (in the reuterin group) as markers for group differentiation. VOC analysis showed a significant decrease of heptane and increase of 3-methylbutanal in the reuterin group.Conclusion: The supernatant produced in this study contained acceptable amounts of 3-HPA remaining stable for 35 days at −20°C and exhibiting an antimicrobial effect against S. aureus, S. agalactiae, and S. epidermidis. Under in vivo conditions, the reuterin supernatant caused alterations of the fecal microbiome. In the fecal, VOC analysis decreased heptane and increased 3-methylbutanal were encountered. These findings suggest the high potential of the reuterin system to influence the intestinal microbiome in health and disease, which needs to be examined in detail in future projects.

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Probiotics of Diverse Origin and Their Therapeutic Applications: A Review

Cited by 28 publications

References 100 publications

Probiotic: An Uprising Human Health Concept

Probiotic: An Uprising Human Health Concept

Novel Insights into the Role of Probiotics in Respiratory Infections, Allergies, Cancer, and Neurological Abnormalities

Production, Storage Stability, and Susceptibility Testing of Reuterin and Its Impact on the Murine Fecal Microbiome and Volatile Organic Compound Profile

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