Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice

Yang, Xueqin; Yu, Dongke; Xue, Li; Li, Hui; Du, Jun-Rong

doi:10.1016/j.apsb.2019.07.001

Cited by 245 publications

(162 citation statements)

References 53 publications

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“…and Bifidobacterium spp. may be capable of effecting mood, anxiety and cognition via the gut–brain axis [ 19 , 109 , 111 , 112 ]; however, this remains unclear. Further research is needed to assess the impact of specific probiotic strains on mood, stress resilience, and psychological states such as anxiety and depression, and for in the context of BS in potential psychologically unstable patients [ 110 ].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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The gastrointestinal (GI) microbiota plays an important role in health and disease, including brain function and behavior. Bariatric surgery (BS) has been reported to result in various changes in the GI microbiota, therefore demanding the investigation of the impact of GI microbiota on treatment success. The goal of this systematic review was to assess the effects of BS on the microbiota composition in humans and other vertebrates, whether probiotics influence postoperative health, and whether microbiota and psychological and behavioral factors interact. A search was conducted using PubMed and Web of Science to find relevant studies with respect to the GI microbiota and probiotics after BS, and later screened for psychological and behavioral parameters. Studies were classified into groups and subgroups to provide a clear overview of the outcomes. Microbiota changes were further assessed for whether they were specific to BS in humans through the comparison to sham operated controls in other vertebrate studies. Changes in alpha diversity appear not to be specific, whereas dissimilarity in overall microbial community structure, and increases in the abundance of the phylum Proteobacteria and Akkermansia spp. within the phylum Verrucomicrobia after surgery were observed in both human and other vertebrates studies and may be specific to BS in humans. Human probiotic studies differed regarding probiotic strains and dosages, however it appeared that probiotic interventions were not superior to a placebo for quality of life scores or weight loss after BS. The relationship between GI microbiota and psychological diseases in this context is unclear due to insufficient available data.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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“…Probiotic supplementation could also considerably improve synaptic plasticity and significantly restore long-term potentiation in the Aβ-administered animals [ 156 ]. With long-term oral ProBiotic-4 (a complex probiotic preparation) administration, senescence-accelerated mouse prone 8 mice showed significant improvement in microbiota composition of the feces and brain, cerebral neuronal and synaptic injuries, and immune response activation [ 157 ]. The underlying mechanism is related to inhibition of both TLR4- and retinoic-acid-inducible gene-I-mediated NF-κB signaling pathways in the brain [ 157 ].…”

Section: Potential Therapeutic Strategies For Ad Targeting the Microbmentioning

confidence: 99%

“…With long-term oral ProBiotic-4 (a complex probiotic preparation) administration, senescence-accelerated mouse prone 8 mice showed significant improvement in microbiota composition of the feces and brain, cerebral neuronal and synaptic injuries, and immune response activation [ 157 ]. The underlying mechanism is related to inhibition of both TLR4- and retinoic-acid-inducible gene-I-mediated NF-κB signaling pathways in the brain [ 157 ]. At present, only one clinical trial has been conducted to assess the effects of probiotic supplementation on AD [ 158 ].…”

Section: Potential Therapeutic Strategies For Ad Targeting the Microbmentioning

confidence: 99%

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

et al. 2020

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Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade. The broadening of the term “microbiota-gut-brain axis” from “gut-brain axis” underscores a bidirectional communication system between the gut and the brain. The microbiota-gut-brain axis involves metabolic, endocrine, neural, and immune pathways which are crucial for the maintenance of brain homeostasis. Alterations in the composition of gut microbiota are associated with multiple neuropsychiatric disorders. Although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, and insulin resistance in the pathogenesis of Alzheimer’s disease (AD). Illustration of the mechanisms underlying the regulation by gut microbiota may pave the way for developing novel therapeutic strategies for AD. In this narrative review, we provide an overview of gut microbiota and their dysregulation in the pathogenesis of AD. Novel insights into the modification of gut microbiota composition as a preventive or therapeutic approach for AD are highlighted.

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“…Probiotic-4 ( B. lactis , B. bifidum , L. casei , and L. acidophilus ) administration was able to attenuate the aging-related disruption of blood–brain barrier and intestinal barrier integrity and reduce the level of plasma and cerebral LPS, as well as IL-6, TNF-α and TLR4, and NF-κB translocation in the brain of aged mice [ 183 ]. In addition, the remarkable improvement of memory deficits, cerebral neuronal and synaptic injuries, microglia activation, and microbial composition were found in the feces and brain of aged mice model [ 183 ]. Chronically stressed mice treated with B. breve CCFM1025 reversed chronic stress-induced depression and anxiety-like behaviors and gut microbiome changes in vivo [ 184 ].…”

Section: Interaction Of Gut and Nervous System: Gut–brain Axismentioning

confidence: 99%

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Suganya

Koo

2020

IJMS

174

112

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The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the largest and vulnerable surface with desirable features to observe foods, nutrients, and environmental factors, as well as to differentiate commensals, invading pathogens, and others. It is well-known that the gut has a strong connection with the central nervous system (CNS) in the context of health and disease. A healthy gut with diverse microbes is vital for normal brain functions and emotional behaviors. In addition, the CNS controls most aspects of the GI physiology. The molecular interaction between the gut/microbiome and CNS is complex and bidirectional, ensuring the maintenance of gut homeostasis and proper digestion. Besides this, several mechanisms have been proposed, including endocrine, neuronal, toll-like receptor, and metabolites-dependent pathways. Changes in the bidirectional relationship between the GIT and CNS are linked with the pathogenesis of gastrointestinal and neurological disorders; therefore, the microbiota/gut-and-brain axis is an emerging and widely accepted concept. In this review, we summarize the recent findings supporting the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. In addition, we highlight the recent advances in improving of neurological diseases by probiotics/prebiotics/synbiotics and fecal microbiota transplantation via the concept of the gut–brain axis.

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Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice

Cited by 245 publications

References 53 publications

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

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