Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity

Srivastav, Sunil Kumar; Neupane, Sabita; Bhurtel, Sunil; Katila, Nikita; Maharjan, Sailesh; Choi, Hyukjae; Hong, Jin Tae; Choi, Dong‐Young

doi:10.1016/j.jnutbio.2019.03.021

Cited by 143 publications

(154 citation statements)

References 52 publications

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“…Similar neuroprotective effects have also been reported using oral administration of probiotics or fecal microbiota transplantation from normal mice in PD animal models [27,67,68]. The role of probiotics in ameliorating dopaminergic neuronal loss could be attributed to their actions of inhibiting glial cell activation and neuroinflammation, increasing butyrate level, and elevating the level of some neurotrophic factors such as brain-derived neurotrophic factor (BDNF) or glial cell line-derived neurotrophic factor (GDNF) [27,67,68]. Earlier studies have reported that the administration of probiotics increased the levels of BDNF and GDNF, which are required for the survival of dopaminergic neurons in vivo [67,69].…”

Section: Discussionsupporting

confidence: 71%

“…The present study, based on the animal behavioral and histological results, indicates that the early (starting at 8 weeks of age) and long-term (16 weeks) probiotic intervention may induce the preservation of several comprehensive motor functions through the protection of the nigrostriatal dopamine neurons. Similar neuroprotective effects have also been reported using oral administration of probiotics or fecal microbiota transplantation from normal mice in PD animal models [27,67,68]. The role of probiotics in ameliorating dopaminergic neuronal loss could be attributed to their actions of inhibiting glial cell activation and neuroinflammation, increasing butyrate level, and elevating the level of some neurotrophic factors such as brain-derived neurotrophic factor (BDNF) or glial cell line-derived neurotrophic factor (GDNF) [27,67,68].…”

Section: Discussionmentioning

confidence: 60%

“…The role of probiotics in ameliorating dopaminergic neuronal loss could be attributed to their actions of inhibiting glial cell activation and neuroinflammation, increasing butyrate level, and elevating the level of some neurotrophic factors such as brain-derived neurotrophic factor (BDNF) or glial cell line-derived neurotrophic factor (GDNF) [27,67,68]. Earlier studies have reported that the administration of probiotics increased the levels of BDNF and GDNF, which are required for the survival of dopaminergic neurons in vivo [67,69]. This could be one of the possible mechanisms that support our finding showing the neuroprotective effects in dopaminergic neurons following long-term treatment of probiotics.…”

Section: Discussionmentioning

confidence: 99%

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Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

et al. 2020

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Parkinson’s disease (PD) is one of the common long-term degenerative disorders that primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals with PD and often present before motor symptoms. It has been found that gut dysbiosis to PD pathology is related to the severity of motor and non-motor symptoms in PD. Probiotics have been reported to have the ability to improve the symptoms related to constipation in PD patients. However, the evidence from preclinical or clinical research to verify the beneficial effects of probiotics for the motor functions in PD is still limited. An experimental PD animal model could be helpful in exploring the potential therapeutic strategy using probiotics. In the current study, we examined whether daily and long-term administration of probiotics has neuroprotective effects on nigrostriatal dopamine neurons and whether it can further alleviate the motor dysfunctions in PD mice. Transgenic MitoPark PD mice were chosen for this study and the effects of daily probiotic treatment on gait, beam balance, motor coordination, and the degeneration levels of dopaminergic neurons were identified. From the results, compared with the sham treatment group, we found that the daily administration of probiotics significantly reduced the motor impairments in gait pattern, balance function, and motor coordination. Immunohistochemically, a tyrosine hydroxylase (TH)-positive cell in the substantia nigra was significantly preserved in the probiotic-treated PD mice. These results showed that long-term administration of probiotics has neuroprotective effects on dopamine neurons and further attenuates the deterioration of motor dysfunctions in MitoPark PD mice. Our data further highlighted the promising possibility of the potential use of probiotics, which could be the relevant approach for further application on human PD subjects.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

et al. 2020

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“…Possibility because of butyrate can induce the BDNF and glial cell line-derived neurotrophic factor (GDNF) upregulated, and monoamine-oxidase was inhibited in the brain. Furthermore, probiotics mixture pretreatment can reduce DA neurons loss, increase the level of DA and reduce the activity of inflammatory cells of brain (Srivastav et al, 2019).…”

Section: Probioticsmentioning

confidence: 99%

Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease

Liu

Nie

et al. 2020

Front. Cell. Infect. Microbiol.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by neuronal loss and dysfunction of dopaminergic neurons located in the substantia nigra, which contain a variety of misfolded a-synuclein (a-syn). Medications that increase or substitute for dopamine can be used for the treatment of PD. Recently, numerous studies have shown gut microbiota plays a crucial role in regulating and maintaining multiple aspects of host physiology including host metabolism and neurodevelopment. In this review article, the role of gut microbiota in the etiological mechanism of PD will be reviewed. Furthermore, we discussed current pharmaceutical medicine-based methods to prevent and treat PD, followed by describing specific strains that affect the host brain function through the gut-brain axis. We explained in detail how gut microbiota directly produces neurotransmitters or regulate the host biosynthesis of neurotransmitters. The neurotransmitters secreted by the intestinal lumen bacteria may induce epithelial cells to release molecules that, in turn, can regulate neural signaling in the enteric nervous system and subsequently control brain function and behavior through the brain-gut axis. Finally, we proved that the microbial regulation of the host neuronal system. Endogenous a-syn can be transmitted long distance and bidirectional between ENS and brain through the circulatory system which gives us a new option that the possibility of altering the community of gut microbiota in completely new medication option for treating PD.

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“…Butyrate is under a wide range of biological functions. Studies have shown that butyrate plays an active role in brain disorders in a variety of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease [9][10][11][12]. Sodium butyrate (NaB) is a common form of butyrate.…”

Section: Introductionmentioning

confidence: 99%

Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro

Sun

Yuan

et al. 2020

Mediators of Inflammation

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Alzheimer’s disease (AD) is a common neurodegenerative disease. Aβ plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against Aβ toxicity and to uncover the underlying mechanisms. The results showed that 2 mM NaB had a significant improvement effect on Aβ-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from Aβ-induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD.

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Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity

Cited by 143 publications

References 52 publications

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease

Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro

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