Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice

Zhao, Hai-Mei; Huang, Xiaoying; Zuo, Zhi-Qin; Pan, Qi-Hong; Ao, Meiying; Zhou, Feng; Liu, Hongning; Liu, Zhiyong; Liu, Duan-Yong

doi:10.3748/wjg.v19.i5.742

Cited by 46 publications

(38 citation statements)

References 27 publications

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“…Second, probiotics interact with the local immune system. An example is that some probiotic strains can enhance regulatory T cell responses, downregulate the expression of pro-inflammatory cytokines, such as TNF-α and IFN-γ [ 113 , 114 ], and induce the production of a variety of anti-inflammatory cytokines, e.g., IL-10 and TGF-β [ 115 ].…”

Section: Therapeutic Opportunities: Pro/prebiotics Diet Interventionmentioning

confidence: 99%

Recipe for IBD: can we use food to control inflammatory bowel disease?

Witkowski

Gagliani

et al. 2017

Semin Immunopathol

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The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the interaction of the intestinal mucosal immune system and the intestinal microbiota in the context of IBD. In addition, we discuss the impact of food components on immune responses in IBD. Finally, we address the current evidence of how this interaction (i.e., immune system–microbiota) can be modulated by food components, pre/probiotics, and fecal microbiota transplantation (FMT) and how these approaches can support intestinal homeostasis. By gathering the vast amount of literature available on the impact of food on IBD, we aim to distinguish between scientifically sound data and theories, which have not been included in this review.

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Section: Therapeutic Opportunities: Pro/prebiotics Diet Interventionmentioning

confidence: 99%

Recipe for IBD: can we use food to control inflammatory bowel disease?

Witkowski

Gagliani

et al. 2017

Semin Immunopathol

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“…Bifico capsules were approved as an over‐the‐counter drug by the Chinese regulatory authority, the State Food and Drug Administration, in 2002 . Previous research has shown that Bifico could relieve gastritis induced by Helicobacter pylori and ameliorate experimental colitis caused by DSS in mice . However, the effect of Bifico on CAC has not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

“…23 Previous research has shown that Bifico could relieve gastritis induced by Helicobacter pylori and ameliorate experimental colitis caused by DSS in mice. 24,25 However, the effect of Bifico on CAC has not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with probiotic Bifico ameliorates colitis‐associated cancer in mice: Transcriptome and gut flora profiling

et al. 2018

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Individuals with inflammatory bowel disease are at high risk of developing colitis‐associated cancer (CAC). Strategies to block the process from inflammatory bowel disease to CAC should be considered. In the experiment, we aim to explore the chemopreventive efficacy of the probiotic cocktail Bifico and its potential mechanism in azoxymethane and dextran sodium sulphate‐induced CAC in mice. Oral pretreatment of Bifico was adopted to evaluate its protective effect. The colorectums of 35 C57BL/6 mice were collected and examined for the degree of inflammation and tumorigenesis. Comparative 16S rRNA sequencing was carried out to observe Bifico‐target alterations in gene expression and microbiota structure. We found that pretreatment of Bifico alleviated intestinal inflammation and reduced tumor formation. Furthermore, we identified a subset of genes as potential targets of Bifico treatment, including CXCL1,CXCL2,CXCL3, and CXCL5, which are all ligands of C‐X‐C motif receptor 2 (CXCR2). The 16S rRNA sequencing showed that Bifico decreased the abundance of genera Desulfovibrio, Mucispirillum, and Odoribacter, and a bloom of genus Lactobacillus was detected. Notably, we found that an abundance of these Bifico‐target taxa was significantly associated with the expression of CXCR2 ligand genes. Our studies indicate that Bifico, given orally, can ameliorate CAC in mice through intervening with the possible link between Desulfovibrio, Mucispirillum, Odoribacter, Lactobacillus, and CXCR2 signaling.

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“…In a study by Macfarlane et al, flora samples in biopsy specimens from the rectums of UC patients were studied through fluorescence in situ hybridization (FISH) with a 16S rRNA probe, and the number of Bifidobacterium in UC patients was about 30-fold less than that in healthy individuals [ 32 ]. Zhao et al found that Bifidobacterium can increase the number of CD4+CD25+Foxp3+ T cells and regulate the balance between Th1 and Th2 cells in the colonic mucosa, thereby reducing intestinal inflammation [ 33 ]. Moreover, Tanabe et al found that Bifidobacterium may suppress the production of the inflammatory factor interleukin- (IL-) 17, thus attenuating intestinal inflammation [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Intestinal Flora of Uygur and Han Ethnic Chinese Patients with Ulcerative Colitis

Yao

Cui

Wang

et al. 2016

Gastroenterology Research and Practice

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Aim. To study the correlation between intestinal flora and ulcerative colitis by analyzing the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii in the intestinal of ulcerative colitis (UC) patients and healthy controls with Uygur and Han ethnic. Methods. Bacterial genomic DNA was extracted from fecal samples and analyzed with real-time fluorescence quantitative polymerase chain reaction (PCR) to identify the abundance of Bacteroides, Fusobacterium, Clostridium, Bifidobacterium spp., and Faecalibacterium prausnitzii. Results. The samples from UC patients, Uygur and Han ethnic combined, had higher abundance of Bacteroides (P = 0.026) but lower Clostridium (P = 0.004), Bifidobacterium spp. (P = 0.009), and Faecalibacterium prausnitzii (P = 0.008) than those from healthy controls. Among UC patients, Bacteroides population was raised in acute UC patients (P ≤ 0.05), while the abundance of Clostridium, Bifidobacterium spp., Fusobacterium, and Faecalibacterium prausnitzii decreased (P ≤ 0.05) compared with the remission. In both UC patients group and control group, no difference was observed in the abundance of these 5 bacteria between the Han and the Uygur group. Conclusions. Variations in the abundance of these five bacterial strains in intestines may be associated with the occurrence of UC in Uygur and Han populations; however, these variations were not associated with ethnic difference.

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Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice

Abstract: Probiotics effectively treat experimental colitis by increasing CD4+CD25+Foxp3+T cell and regulating the balance of Th1 and Th2 cytokines in the colonic mucosa.

Cited by 46 publications

References 27 publications

Recipe for IBD: can we use food to control inflammatory bowel disease?

Recipe for IBD: can we use food to control inflammatory bowel disease?

Pretreatment with probiotic Bifico ameliorates colitis‐associated cancer in mice: Transcriptome and gut flora profiling

Quantitative Analysis of Intestinal Flora of Uygur and Han Ethnic Chinese Patients with Ulcerative Colitis

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