Probiotics in pediatrics

Depoorter, Leontien; Vandenplas, Yvan

doi:10.1016/b978-0-323-85170-1.00014-2

Cited by 6 publications

(4 citation statements)

References 129 publications

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“…While we are fully aware that there are more RCTs assessing probiotics in the pediatric population, comprehensive documentation of all existing literature was not the goal of this review. The trials on antibiotic‐associated diarrhea, acute diarrhea, necrotizing enterocolitis, atopic dermatitis, respiratory tract infections, and H pylori infection constitute the vast majority of the RCTs assessing probiotic use in childhood disease (51,52). Because of that, in our opinion, the presented data are sufficient to credibly reflect the scope of the amount of clinical evidence on probiotic strain‐specificity in children and the inclusion of additional remaining studies would not significantly change this review’s conclusions.…”

Section: Discussionmentioning

confidence: 99%

Strain-Specificity of Probiotics in Pediatrics: A Rapid Review of the Clinical Evidence

Jankiewicz

Łukasik²,

Kotowska³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objective:The dogma of probiotic strain-specificity is widely accepted. However, only the genus-and species-specific effects of probiotics are supported by evidence from clinical trials. The aim of this rapid review was to assess clinical evidence supporting the claim that the efficacy of probiotics in the pediatric population is strain-specific. Methods: The Cochrane Library, MEDLINE, and EMBASE databases were searched (up to August 2022) for randomized controlled trials (RCTs) conducted in children aged 0-18 years evaluating the effects of prophylactic or therapeutic administration of probiotics (well-characterized at the strain level) for conditions such as antibiotic-associated diarrhea, acute diarrhea, necrotizing enterocolitis, respiratory tract infections, Helicobacter pylori infection, and atopic dermatitis. To allow evaluation of strain-specificity, a trial could only be included in the review if at least one additional RCT assessed the effect of a different strain of the same species against the same comparator. RCTs without proper strain-level data were excluded. In the absence of identifying head-to-head strain versus strain RCTs, indirect comparisons were made between interventions. Results: Twenty-three RCTs were eligible for inclusion. Out of the 11 performed comparisons, with 1 exception (two Lacticaseibacillus paracasei strains in reducing atopic dermatitis symptoms), no significant differences between the clinical effects of different strains of the same probiotic species were found. Conclusions: Head-to-head comparison is an optimal study design to compare probiotic strains, but such comparisons are lacking. Based on indirect comparisons, this rapid review demonstrates insufficient clinical evidence to support or refute the claim that probiotic effects in children are strainspecific.

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Section: Discussionmentioning

confidence: 99%

Strain-Specificity of Probiotics in Pediatrics: A Rapid Review of the Clinical Evidence

Jankiewicz

Łukasik²,

Kotowska³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…This in turn aided the shortening of the diarrheal period and reducing its severity. The predominant species used on commercial levels include Lactobacillus , Streptococcus , Enterococcus , Lactococcus , Pediococcus , Bacillus , Escherichia , and sometimes Saccharomyces [ 59 ]. The American Gastroenterology Association (AGA), in its 2020 guidelines, despite indicating that there are knowledge gaps regarding the impact of probiotics on post-infection conditions, conditionally recommended the use of probiotics during antibiotic treatment.…”

Section: Nutritional Interventionsmentioning

confidence: 99%

Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections

2023

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Enteric protozoan pathogenic infections significantly contribute to the global burden of gastrointestinal illnesses. Their occurrence is considerable within remote and indigenous communities and regions due to reduced access to clean water and adequate sanitation. The robustness of these pathogens leads to a requirement of harsh treatment methods, such as medicinal drugs or antibiotics. However, in addition to protozoal infection itself, these treatments impact the gut microbiome and create dysbiosis. This often leads to opportunistic pathogen invasion, anti-microbial resistance, or functional gastrointestinal disorders, such as irritable bowel syndrome. Moreover, these impacts do not remain confined to the gut and are reflected across the gut–brain, gut–liver, and gut–lung axes, among others. Therefore, apart from medicinal treatment, nutritional supplementation is also a key aspect of providing recovery from this dysbiosis. Future proteins, prebiotics, probiotics, synbiotics, and food formulations offer a good solution to remedy this dysbiosis. Furthermore, nutritional supplementation also helps to build resilience against opportunistic pathogens and potential future infections and disorders that may arise due to the dysbiosis. Systems biology techniques have shown to be highly effective tools to understand the biochemistry of these processes. Systems biology techniques characterize the fundamental host–pathogen interaction biochemical pathways at various infection and recovery stages. This same mechanism also allows the impact of the abovementioned treatment methods of gut microbiome remediation to be tracked. This manuscript discusses system biology approaches, analytical techniques, and interaction and association networks, to understand (1) infection mechanisms and current global status; (2) cross-organ impacts of dysbiosis, particularly within the gut–liver and gut–lung axes; and (3) nutritional interventions. This study highlights the impact of anti-microbial resistance and multi-drug resistance from the perspective of protozoal infections. It also highlights the role of nutritional interventions to add resilience against the chronic problems caused by these phenomena.

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“…Probiotics have come into action as medical remedies for gastrointestinal and non-gastrointestinal ailments such as diarrhoea, irregular bowel movements, inflammatory reactions, etc. (Depoorter & Vandenplas 2022). The maintenance of health using probiotics is based on the principle of competitive interaction of probiotics with pathogens surviving in the intestinal medium by inhibiting their harmful activities (Bermudez-Brito et al 2012).…”

Section: Health Benefits Of Probioticsmentioning

confidence: 99%

Probiotics media: significance, challenges, and future perspective - a mini review

Kumar

Naik

Kumar

et al. 2022

Food Prod Process and Nutr

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The health benefits associated with probiotics have increased their application in pharmaceutical formulations and functional food development. High production of probiotic biomass requires a cost-effective production method and nutrient media optimization. The biomass production of probiotics can be enhanced by optimizing growth parameters such as substrate, pH, incubation time, etc. For economical industrial production of probiotic biomass, it is required to design a new medium with low cost. Wastes from the food industries are promising components for the development of the low-cost medium. Industrial wastes such as cheese whey and corn steep liquor are excellent examples of reliable sources of nitrogen for the biomass production of probiotic bacteria. The increased yield of biomass reduced the cost of production. This review focuses on the importance of probiotic media for biomass production and its challenges. Graphical Abstract

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Probiotics in pediatrics

Cited by 6 publications

References 129 publications

Strain-Specificity of Probiotics in Pediatrics: A Rapid Review of the Clinical Evidence

Strain-Specificity of Probiotics in Pediatrics: A Rapid Review of the Clinical Evidence

Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections

Probiotics media: significance, challenges, and future perspective - a mini review

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