Probiotics in infective diarrhoea and inflammatory bowel diseases

Gionchetti, Paolo; Rizzello, Fernando; Venturi, Alessandro; Campieri, Massimo

doi:10.1046/j.1440-1746.2000.02162.x

Cited by 118 publications

(71 citation statements)

References 41 publications

(35 reference statements)

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“…Administration of anti-TNF-␣ Ab or soluble TNF-␣ receptor has been shown to inhibit colitis (17). Ab blockade of ICAM-1 and VCAM-1 also ameliorates inflammation in an adoptive transfer mouse model of CD (18).…”

Section: Inhibition Of Ifn-␥-inducible Protein-10 Abrogates Colitis Imentioning

confidence: 99%

Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice

Singh

Taub

et al. 2003

The Journal of Immunology

139

136

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A deficiency in understanding the steps responsible for colitis is the lack of comprehension for the role chemokines play in mucosal inflammation. IFN-γ-inducible protein-10 (IP-10) and CXCR3 are highly expressed at sites of colitis. Our findings show that IP-10 significantly contributes to the development of Th1 and inflammatory responses. Specifically, IP-10 inhibition in IL-10−/− mice attenuates the associated increases in serum and/or local amyloid A, IL-2, IL-6, TNF-α, IFN-γ, IL-1α, and IL-1β with colitis as compared with IL-10−/− mice that develop colitis similar to human Crohn’s disease. Correspondingly, the rate or intensity of inflammation in IL-10−/− mice treated with anti-IP-10 Abs showed improved scoring of inflammation, compared with control IL-10−/− mice. This study provides important and novel information regarding IP-10 as a target for the treatment of colitis.

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Section: Inhibition Of Ifn-␥-inducible Protein-10 Abrogates Colitis Imentioning

confidence: 99%

Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice

Singh

Taub

et al. 2003

The Journal of Immunology

139

136

View full text Add to dashboard Cite

show abstract

“…Some like Lactobacillus, Streptococcus, Pediococcus, and Enterococcus are cultivable and predominant microbes in fermented dairy products, and exert a positive role in human health following oral administration. They improve the balance of the microbial community in the intestine, confer protection against potential pathogenic bacteria, and prevent and/or cure intestinal diseases (Schiffrin et al, 1997;Gionchetti et al, 2000). These effects are mediated by production of antimicrobial metabolites such as organic acids (for example lactate, acetate, and butyrate), hydrogen peroxide, and bacteriocins, and competition with harmful bacteria for nutrients or adhesion receptors (Hudault et al, 1997;Fons et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Probiotic properties of lactic acid bacteria isolated from traditionally fermented Xinjiang cheese

Azat

Lü

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Six lactic acid bacterial (LAB) strains were isolated from traditionally fermented Xinjiang cheese and evaluated for functional and probiotic properties and potentials as starter cultures. The isolated six LAB strains comprised Lactobacillus rhamnosus (one strain), Lactobacillus helveticus (one strain), and Enterococcus hirae (four strains). All of the six strains were tolerant to acidic and bile salt conditions. Among which, the L. rhamnosus R4 strain showed more desirable antimicrobial, auto-aggregation, and hydrophobic activity. In addition, the strain L. rhamnosus R4 exhibited the highest level of free radical scavenging activity (53.78% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals and 45.79% of hydroxyl radicals). L. rhamnosus R4 also demonstrated cholesterol and triglyceride degradation by 50.97% and 28.92%, respectively. To further examine the health-promoting effects of these LAB strains on host lifespan, Caenorhabditis elegans was used as an in vivo model. Worms fed LAB as a food source had significant differences in lifespan compared to those fed Escherichia coli OP50 (as a negative control). Feeding of L. rhamnosus R4 extended the mean lifespan of C. elegans by up to 36.1% compared to that of the control. The results suggest that the strains isolated from Xinjiang fermented dairy products have high potential as starter cultures in the cheese industry.

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“…Probiotics are live organisms that, when ingested, promote beneficial health effects and well being to the host. Probiotic organisms have been used to treat a variety of human intestinal conditions, including diarrhea (22,32), and aspects of inflammatory bowel disease (IBD), such as pouchitis (11). Organisms used as probiotics are most frequently of the Lactobacilli or Bifidobacterium species.…”

mentioning

confidence: 99%

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

Kleij¹,

O’Mahony²,

Shanahan³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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CD62Lϩ T lymphocytes from BALB/c into SCID mice. LR and BI (1 ϫ 10 9 ) were given daily. Clinical score, myeloperoxidase (MPO) levels, and in vivo and in vitro secreted inflammatory cytokine levels were found to be more severe in mice that were vagotomized compared with shamoperated animals. LR in the acute DSS model was effective in decreasing the MPO and cytokine levels in the tissue in sham and vagotomized mice. BI had a strong downregulatory effect on secreted in vitro cytokine levels and had a greater anti-inflammatory effect in vagotomized-compared with sham-operated mice. Both LR and BI retained anti-inflammatory effects in vagotomized mice. In SCID mice, vagotomy did not enhance inflammation, but BI was more effective in vagotomized mice than shams. Taken together, the intact vagus has a protective role in acute DSS-induced colitis in mice but not in the chronic T cell transfer model of colitis. Furthermore, LR and BI do not seem to engage their protective effects via this cholinergic anti-inflammatory pathway, but the results interestingly show that, in the T cell, transfer model vagotomy had a biological effect, since it increased the effectiveness of the BI in downregulation of colonic inflammation.

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Probiotics in infective diarrhoea and inflammatory bowel diseases

Cited by 118 publications

References 41 publications

Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice

Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10−/− Mice

Probiotic properties of lactic acid bacteria isolated from traditionally fermented Xinjiang cheese

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

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