Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial

Woodard, Gavitt A.; Encarnacion, Betsy; Downey, John; Peraza, Joseph; Chong, Karen P.; Hernandez‐Boussard, Tina; Morton, John M.

doi:10.1007/s11605-009-0891-x

Cited by 176 publications

(127 citation statements)

References 34 publications

(34 reference statements)

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…In this study, Faecalibacterium prausnitzii was found to be directly linked to the reduction in the low-grade infl ammatory state in obesity and diabetes, independently of caloric intake. Th e potential role of the gut microbiota on weight loss aft er RYGB was also recently suggested by the demonstration of enhanced weight loss following administration of a probiotic postoperatively ( 44 ).…”

confidence: 94%

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

DiBaise¹,

Frank²,

Mathur³

2012

Am J Gastroenterol Suppl

125

View full text Add to dashboard Cite

confidence: 94%

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

DiBaise¹,

Frank²,

Mathur³

2012

Am J Gastroenterol Suppl

125

View full text Add to dashboard Cite

“…Nevertheless, as mentioned below, correlations with successful weight loss were seen going further down in taxonomy beyond the phylum level. Moreover, a study analyzing weight loss after metabolic surgery (gastric bypass) found a significant increase in the amount of lost kilograms in the group receiving a lactobacillus probiotic for 6 months compared to the placebo group [28]. A direct effect of the lactobacillus strains seems rather doubtful, as bacterial overgrowth was simultaneously revealed to have decreased in the probiotic group, pointing rather towards a contribution of the microbial composition on the whole.…”

Section: Microbiota and Nutrition/obesitymentioning

confidence: 99%

Environmental Factors and Their Impact on the Intestinal Microbiota: A Role for Human Disease?

Biedermann

Rogler

2012

Dig Dis

View full text Add to dashboard Cite

The intestinal microbiota and its potential role in human health and disease have come into the focus of interest in recent years. An important prerequisite for the achieved advances with regard to a better characterization of its complex composition and influencing factors is the increasing availability and affordability of culture-independent methods, such as high-throughput sequencing technologies. We discuss some general aspects of the intestinal microbiota. Recent insights into its potential pathogenetic role in the metabolic syndrome and inflammatory bowel disease will also be discussed that imply an impact of smoking status and smoking cessation on intestinal microbial composition.

show abstract

“…Probiotics have been reported to suppress diarrhea [12], alleviate lactose intolerance [13] and postoperative complications [14], exhibit antimicrobial [15] and anti-colorectal cancer activities [16,17], reduce irritable bowel symptoms [18] and prevent inflammatory bowel disease [19]. However, generalizations concerning the potential health benefits of probiotics should not be made because probiotic effects tend to be strain specific.…”

Section: Introductionmentioning

confidence: 99%

Probiotic Mechanisms of Action

et al. 2012

View full text Add to dashboard Cite

Probiotics are live microorganisms that provide health benefits to the host when ingested in adequate amounts. The strains most frequently used as probiotics include lactic acid bacteria and bifidobacteria. Probiotics have demonstrated significant potential as therapeutic options for a variety of diseases, but the mechanisms responsible for these effects have not been fully elucidated yet. Several important mechanisms underlying the antagonistic effects of probiotics on various microorganisms include the following: modification of the gut microbiota, competitive adherence to the mucosa and epithelium, strengthening of the gut epithelial barrier and modulation of the immune system to convey an advantage to the host. Accumulating evidence demonstrates that probiotics communicate with the host by pattern recognition receptors, such as toll-like receptors and nucleotide-binding oligomerization domain-containing protein-like receptors, which modulate key signaling pathways, such as nuclear factor-ĸB and mitogen-activated protein kinase, to enhance or suppress activation and influence downstream pathways. This recognition is crucial for eliciting measured antimicrobial responses with minimal inflammatory tissue damage. A clear understanding of these mechanisms will allow for appropriate probiotic strain selection for specific applications and may uncover novel probiotic functions. The goal of this systematic review was to explore probiotic modes of action focusing on how gut microbes influence the host.

show abstract

Probiotics Improve Outcomes After Roux-en-Y Gastric Bypass Surgery: A Prospective Randomized Trial

Abstract: In this novel study, probiotic administration improves bacterial overgrowth, vitamin B12 availability, and weight loss after RNYGB. These data may provide further evidence that altering the GI microbiota can influence weight loss.

Cited by 176 publications

References 34 publications

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

Impact of the Gut Microbiota on the Development of Obesity: Current Concepts

Environmental Factors and Their Impact on the Intestinal Microbiota: A Role for Human Disease?

Probiotic Mechanisms of Action

Contact Info

Product

Resources

About