Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials

Cuello-Garcia, Carlos A.; Brožek, Jan; Fiocchi, Alessandro; Pawankar, Ruby; Yepes-Núñez, Juan José; Terracciano, Luigi; Gandhi, Shreyas; Agarwal, Arnav; Zhang, Yuan; Schünemann, Holger J.

doi:10.1016/j.jaci.2015.04.031

Cited by 324 publications

(236 citation statements)

References 43 publications

(96 reference statements)

Supporting

Mentioning

207

Contrasting

Unclassified

Order By: Relevance

“…In particular, the possibility that a starter culture is the source of mobile gene elements suggests that the genomic content, rather than just specific species, must be considered when designing microbial supplements. In addition to starter cultures used for fermented foods, living microbial supplements ('probiotics') are increasingly being adopted in agriculture (Verschuere et al, 2000;Chaucheyras-Durand and Durand, 2010) and for a wide range of human health conditions (Cuello-Garcia et al, 2015;Onubi et al, 2015; (IBS Dietetic Guideline Review Group on behalf of Gastroenterology Specialist Group of the British Dietetic Association) et al, 2016), and even as cosmetics (Whitlock et al, 2016). The need to screen for clinically relevant elements such as antibiotic resistance genes is widely recognized (Sanders et al, 2010), but other mobile gene elements from these organisms may also enter native microbial populations with unknown consequences.…”

Section: Discussionmentioning

confidence: 99%

Extensive Horizontal Gene Transfer in Cheese-Associated Bacteria

Bonham

Wolfe

Dutton

2016

Preprint

View full text Add to dashboard Cite

Acquisition of genes through horizontal gene transfer (HGT) allows microbes to rapidly gain new capabilities and adapt to new or changing environments. Identifying widespread HGT regions within multispecies microbiomes can pinpoint the molecular mechanisms that play key roles in microbiome assembly. We sought to identify horizontally transferred genes within a model microbiome, the cheese rind. Comparing 31 newly sequenced and 134 previously sequenced bacterial isolates from cheese rinds, we identified over 200 putative horizontally transferred genomic regions containing 4733 protein coding genes. The largest of these regions are enriched for genes involved in siderophore acquisition, and are widely distributed in cheese rinds in both Europe and the US. These results suggest that HGT is prevalent in cheese rind microbiomes, and that identification of genes that are frequently transferred in a particular environment may provide insight into the selective forces shaping microbial communities.

show abstract

Section: Discussionmentioning

confidence: 99%

Extensive Horizontal Gene Transfer in Cheese-Associated Bacteria

Bonham

Wolfe

Dutton

2016

Preprint

View full text Add to dashboard Cite

show abstract

“…One of the main questions to answer is to whom you may supplement. Studies have been conducted with different modes of supplementation, supplementing only mothers during gestation, only mothers during breastfeeding, only infants after delivery or both mothers during gestation and infants after delivery [54]. Probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects on childhood allergic disease [55].…”

Section: Probiotics In Human Allergy Prevention Trialsmentioning

confidence: 99%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

View full text Add to dashboard Cite

The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

show abstract

“…31 Los probióticos usados en la madre, en la gestación y durante la lactancia y en los primeros años de la vida del niño reducen el riesgo de dermatitis atópica. 32 No tienen el mismo efecto en la prevención de la rinitis y el asma, 33 por lo que se necesitan más evidencias para su recomendación en alergia respiratoria.…”

Section: Probióticosunclassified

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

2016

Arch Argent Pediat

View full text Add to dashboard Cite

RESUMENLas enfermedades alérgicas tienen una prevalencia creciente de modo universal y ocasionan alto impacto sanitario. La investigación está dirigida al estudio de los factores etiológicos y de riesgo de estas enfermedades, que pueden ser potencialmente modificados con estrategias de prevención primaria, secundaria y terciaria. Muchas de esas medidas no tienen un efecto comprobado de manera definitiva, dado que se realizan en un contexto controlado diferente a lo que ocurre en la vida real. Este documento tiene por objetivo revisar las evidencias más actuales sobre prevención de las enfermedades alérgicas considerando las certezas y cuestiones por resolver, y está especialmente centrado en las medidas ambientales, dietéticas, farmacológicas e inmunológicas para los distintos niveles preventivos. Es imperativo un mejor conocimiento de genes y factores ambientales responsables de las enfermedades alérgicas para optimizar las medidas preventivas que permitan revertir la creciente prevalencia de estas enfermedades en la infancia. Palabras clave: alergia, prevención, asma, control ambiental, inmunoterapia. ABSTRACTAllergic diseases have an increasing worldwide prevalence and a great impact on the health related costs. The research is focused on the study of etiological and risk factors of allergic diseases that can potentially be modified with primary, secondary and tertiary prevention strategies. Many of these measures do not have a definitively proven effect taking place in a controlled context different to what happens in real life. This paper aims to review the latest evidence on prevention of allergic diseases considering certainties and unresolved issues and focuses mainly on environmental, dietary, pharmacological and immunological preventive strategies for different levels of prevention. It is imperative to have a better understanding of genetic and environmental factors that cause allergic diseases to optimize preventive measures that are effective in reversing the increasing trend in the prevalence of allergic illnesses in childhood. Key words : allergy, prevention, asthma, environmental control, immunotherapy. http://dx.doi.org/10.5546/aap.2016.277 INTRODUCCIÓNL a s e n f e r m e d a d e s a l é r g i c a s constituyen las patologías crónicas más frecuentes en la edad pediátrica, c o n e l e v a d o s c o s t o s s a n i t a r i o s para el diagnóstico y tratamiento y afectación de la calidad de vida.1 . En Latinoamérica, aproximadamente el Comité Nacional de Alergia Documento de toma de posición Documento desarrollado en el marco del 50° aniversario del

show abstract

Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials

Cited by 324 publications

References 43 publications

Extensive Horizontal Gene Transfer in Cheese-Associated Bacteria

Extensive Horizontal Gene Transfer in Cheese-Associated Bacteria

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Prevención de las enfermedades alérgicas en la infancia: entre la teoría y la realidad

Contact Info

Product

Resources

About