Probiotics do have a role to play in treating critically ill children

Williams, Vijai; Angurana, Suresh Kumar

doi:10.1111/apa.14510

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…On the seventh day of probiotic administration, the tumor necrosis factor α, IL-6, IL-7, and IL12P70 as pro-inflammatory cytokines were significantly reduced; additionally, an increase in IL-10 as anti-inflammatory cytokines occurred in children with severe sepsis. 78 In low birth weight infants, another randomized controlled trial study was performed with a new formulation of synbiotics (contains Lactobacillus and Bifidobacterium together with oligosaccharides) and lactoferrin to evaluate its effect on necrotizing enterocolitis or sepsis, but the results revealed that this compound did not effect on improving necrotizing enterocolitis, sepsis, and reducing mortality. 79 As mentioned, various factors are involved in the onset of sepsis, including disturbance in the integrity of the intestinal barrier.…”

Section: Probiotics Prebiotics and Synbiotics Based Treatment In Infa...mentioning

confidence: 99%

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Interaction Between Altered Gut Microbiota and Sepsis: A Hypothesis or an Authentic Fact?

Nabizadeh

Sadeghi

Rezaee

et al. 2022

J Intensive Care Med

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Sepsis, as an important public health concern, is one of the leading causes of death in hospitals around the world, accounting for 25% of all deaths. Nowadays, several factors contribute to the development of sepsis. The role of the gut microbiota and the response state of the aberrant immune system is dominant. The effect of the human microbiome on health is undeniable, and gut microbiota is even considered a body organ. It is now clear that the alteration in the normal balance of the microbiota (dysbiosis) is associated with a change in the status of immune system responses. Owing to the strong association between the gut microbiota and its metabolites particularly short-chain fatty acids with many illnesses, the gut microbiota has a unique position in the research of microbiologists and even clinicians. This review aimed to analyze studies’ results on the association between microbiota and sepsis, with a substantial understanding of their relationship. As a result, an extensive and comprehensive search was conducted on this issue in existing databases.

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Section: Probiotics Prebiotics and Synbiotics Based Treatment In Infa...mentioning

confidence: 99%

Section: The Microbiome and Other Related Compounds As Therapeutic Ta...mentioning

confidence: 99%

Interaction Between Altered Gut Microbiota and Sepsis: A Hypothesis or an Authentic Fact?

Nabizadeh

Sadeghi

Rezaee

et al. 2022

J Intensive Care Med

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“…Critical illness itself or its treatment can influence the composition of microbiota [107,108]. Although broad-spectrum antibiotics are probably the factor which further alters its composition, other factors can alter the ecosystem in which develops the microbiota, such as enteral or parenteral feeding, drugs administration, disease co-morbidities, central venous catheters, or intubation and mechanical ventilation.…”

Section: Microbiome In Critical Ill Childrenmentioning

confidence: 99%

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

et al. 2020

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Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding.

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“…We are grateful to Williams and Kumar Angurana for their comments on our paper in Acta Paediatrica and for providing the references to their own work on the use of probiotics for critically ill patients .…”

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confidence: 99%