Probiotics Dietary Supplementation for Modulating Endocrine and Fertility Microbiota Dysbiosis

Abstract

Human microbiota seems to play a key role in endocrine and reproductive systems. Fortunately, microbiota reproductive dysbiosis start to be treated by probiotics using typical species from genus Lactobacillus. This work presents the compiled and analysed results from the most up-to-date information from clinical trials regarding microbiota, fertility, probiotics and oral route administration, reviewing open access scientific documents. These studies analyse the clinical impact of probiotics administered on several endocrine disorders’ manifestations in women: mastitis; vaginal dysbiosis; pregnancy complication disorders; and polycystic ovary syndrome. In all cases, the clinical modulation achieved by probiotics was evaluated positively through the improvement of specific disease outcomes with the exception of the pregnancy disorders studies, where the sample sizes results were statistically insufficient. High amounts of studies were discarded because no data were provided on specific probiotic strains, doses, impact on the individual autochthon microbiota, or data regarding specific hormonal values modifications and endocrine regulation effects. However, most of the selected studies with probiotics contained no protocolised administration. Therefore, we consider that intervention studies with probiotics might allocate the focus, not only in obtaining a final outcome, but in how to personalise the administration according to the disorder to be palliated.

Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis

“…Except for these two studies [ 51 , 52 ], the mean administration time found in the review was 1 week. When we compare these data with the oral administration of probiotics in reproductive disorders [ 45 ], it is observed that the range of CFU/day administered is similar to that of vaginal probiotics, from 1 × 10 6 CFU/day to 3 × 10 10 CFU/day. However, in terms of treatment duration, the differential range is much more pronounced, varying from 3 to 24 weeks; this could be due to oral probiotics needing a longer duration to reach the natural reproductive site of colonization compared to the more localized site-direct administration for vaginal probiotics.…”

“… Vaginal probiotics Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Complementary oral probiotics PRISMA was previously performed [ 45 ]. …”

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

“…The first probiotics were composed predominantly of members of Lactobacillus and Bifidobacterium, but they showed a lack of precision when targeting a specific biological function [136]. In the male reproductive field, the use of probiotics and synbiotics (formulations including probiotics and prebiotics) was related to improved semen quality [137,138], and in females the protective role of probiotics in relation to vaginal infections was observed [70,139]. A recent study aimed to select potential probiotic strains from vaginal samples to improve the health of the female reproductive tract, and selected the Lactobacillus rhamnosus BPL005 strain for its capacity to reduce pH and produce short chain fatty acids, protective effects against pathogen colonisation and lactate production [140].…”

Role of probiotics to combat viral infections with emphasis on COVID-19

“…The normal gastrointestinal microflora of the humans is populated with microflora that belongs to the genus Lactobacillus and Bifidobacterium . They are safe and widely used in yogurts and other dairy products (López-Moreno and Aguilera 2020 ). Probiotics play a role in balancing the host defensive immune response, thereby stimulating mucosal barrier function and modulating the immune system (El Hage et al 2017 ).…”