Probiotics and prebiotics in dermatology

Nole, Katherine L. Baquerizo; Yim, Elizabeth; Keri, Jonette

doi:10.1016/j.jaad.2014.04.050

Cited by 115 publications

(49 citation statements)

References 76 publications

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“…Several members of the Lactobacillus genus, for instance, have been associated with protective effects against Staphylococcus aureus infections, 40 atopic dermatitis, 41,42 and acne. 43 In the present study, we observed a sustained, 4.7-fold decrease in Lactobacillus species relative to baseline 8 weeks following discontinuation of minocycline treatment, but whether this presents increased risk for skin infections remains to be determined. Understanding the timing and significance of shifts in microbial flora associated with antibiotic treatment, both during and after therapy, may help clinicians decrease the likelihood of skin comorbidities related to dysbiosis.…”

Section: Discussionmentioning

confidence: 53%

Association of Systemic Antibiotic Treatment of Acne With Skin Microbiota Characteristics

Chien¹,

Tsai²,

Leung³

et al. 2019

JAMA Dermatol

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IMPORTANCE Given the widespread use of systemic antibiotics for treatment of moderate to severe acne, it is important to understand the associations of such antibiotic use with changes not only in Cutibacterium acnes (formerly Propionibacterium acnes) but also in the complete bacterial community of the skin. OBJECTIVE To examine the composition, diversity, and resilience of skin microbiota associated with systemic antibiotic perturbation in individuals with acne. DESIGN, SETTING, AND PARTICIPANTS This longitudinal cohort study conducted at an academic referral center in Maryland from February 11 to September 23, 2014, included 4 female participants who had received a recent diagnosis of acne vulgaris, showed comedonal and inflammatory acne on the face, were at least 18 years old, and had no recent use of systemic or topical treatments for acne, including antibiotics and retinoids. Data analysis was performed between July 5, 2017, and November 7, 2018. INTERVENTIONS Participants were prescribed oral minocycline, 100 mg, twice daily for 4 weeks. Skin areas on the forehead, cheek, and chin were sampled for 16S ribosomal RNA gene sequencing at baseline, 4 weeks after starting minocycline treatment, and then 1 week and 8 weeks after discontinuation of treatment. MAIN OUTCOMES AND MEASURES Skin microbiota examined with respect to relative abundance of bacterial taxa, a diversity (represents within-sample microbial diversity), and β diversity (represents between-sample microbial diversity). Acne status evaluated with photography and lesion count. RESULTS Of the 4 patients included in this study, 2 were 25 years old, 1 was 29 years old, and 1 was 35 years old; 2 were white women, 1 was an African American woman, and 1 was an Asian woman. Across all 4patients, antibiotic treatment was associated with a 1.4-fold reduction in the level of Cacnes (difference, −10.3%; 95% CI, −19.9% to −0.7%; P = .04) with recovery following cessation of treatment. Distinct patterns of change were identified in multiple bacterial genera, including a transient 5.6-fold increase in the relative abundance of Pseudomonas species (difference, 2.2%; 95% CI, 0.9%−3.4%; P < .001) immediately following antibiotic treatment, as well asa persistent 1.7-fold increase in the relative abundance of Streptococcus species (difference, 5.4%; 95% CI, 0.3%−10.6%; P = .04) and a 4.7-fold decrease in the relative abundance of Lactobacillus species (difference, −0.8%; 95% CI, −1.4% to −0.2%; P = .02) 8 weeks following antibiotic treatment withdrawal. In general, antibiotic administration was associated with an initial decrease from baseline of bacterial diversity followed by recovery. Principal coordinates analysis results showed moderate clustering of samples by patient (analysis of similarity, R = 0.424; P = .001) and significant clustering of samples by time in one participant (analysis of similarity, R = 0.733; P = .001). CONCLUSIONS AND RELEVANCE In this study, systemic antibiotic treatment of acne was associated with changes in the composition an...

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Section: Discussionmentioning

confidence: 53%

Association of Systemic Antibiotic Treatment of Acne With Skin Microbiota Characteristics

Chien¹,

Tsai²,

Leung³

et al. 2019

JAMA Dermatol

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“…Acne formation is dependent upon several processes, including follicular hyperkeratinization, excess sebum production, Propiobacterium acnes colonization, and an inflammatory cascade (Baquerizo Nole et al, 2014). Successful acne outcomes are influenced by compliance with topical regimens that can commonly cause skin barrier disruption, leading to dryness and irritation.…”

Section: Acnementioning

confidence: 99%

The effect of probiotics on immune regulation, acne, and photoaging

Kober

Bowe

2015

International Journal of Women's Dermatology

121

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Probiotics are live micro-organisms that provide a health benefit to the host. The role of probiotics in the management of disease, as well as immune modification, has recently experienced a renewed interest in society, as probiotics can be found in products ranging from yogurt to facial creams. In this article, we discuss the role of probiotics in the development of the immune system, the treatment of acne and rosacea, and protection against aging and photodamage.

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“…Overall, prenatal followed by postnatal administration of probiotics are protective against the development of pediatric AD, and Lactobacillus rhamnosus GG (LBR) and Bifidobacterium are the most effective probiotic strains (7). Another metaanalysis found that there is a 20-24% reduction in the incidence of pediatric AD with maternal prenatal and postnatal probiotic supplementation (8). Infants with a low diversity of gut microbiota during the first month of life have an increased risk of developing atopic eczema (9).…”

Section: Update: Do Probiotics Prevent or Treat Pediatric Atopic Dermmentioning

confidence: 99%