The effect of probiotics on immune regulation, acne, and photoaging

Kober, Mary-Margaret; Bowe, Whitney P.

doi:10.1016/j.ijwd.2015.02.001

Cited by 131 publications

(123 citation statements)

References 62 publications

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“…In vitro studies have shown the capacity of probiotics, such as Streptococcus salivarius and Enterococcus faecalis, to directly inhibit P. acnes growth through antibacterial proteins’ production, as detailed in this article. An example of antibacterial protein is the Bacteriocin‐like inhibitory substance (BLIS), which can cause significant inhibition in the growth of P. acnes . Additionally, its immunomodulatory effects in keratinocytes and epithelial cells suggest a physiological mechanism to support its use as adjuvant in acne treatment .…”

Section: Resultsmentioning

confidence: 99%

“…An example of antibacterial protein is the Bacteriocin‐like inhibitory substance (BLIS), which can cause significant inhibition in the growth of P. acnes . Additionally, its immunomodulatory effects in keratinocytes and epithelial cells suggest a physiological mechanism to support its use as adjuvant in acne treatment . Probiotics show potential for direct and indirect benefits in the condition's treatment: directly by inhibiting P. acnes growth and decreasing the characteristic inflammatory response, and indirectly by softening side effects from current treatments.…”

Section: Resultsmentioning

confidence: 99%

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An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Mottin

Suyenaga

2018

Int J Dermatology

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Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. The review was made through bibliographic search of the main databases (Science Direct, PubMed, Scielo, Medline) between September 2015 and June 2016. Acne lesions create an environment that facilitates the excess growth of Propionibacterium acnes (P. acnes). AD is related to an increase in the proportion of Staphylococcus aureus (S. aureus) during flare-ups. Some microorganisms have been shown to act not only in the prevention but also in the competition for pathogenic microorganisms and beneficially affect the inflammatory process present in these conditions. Despite the high variety of tested bacteria, Staphylococcus, Streptococcus, Lactococcus, Lactobacillus, and Enterococcus are the ones which showed the highest potential to control acne, and Vitreoscilla filiformis (V. filiformis), Staphylococcus epidermidis (S. epidermidis), and species of Lactobacillus and Bifidobacterium in the treatment of AD. Many of these studies were in vitro, and more detailed research should be performed in order to prove the real efficacy and safety of probiotics in these situations. An interesting alternative seems to be the use of Bacteriocin-like inhibitory substances produced by probiotics, responsible for their antimicrobial activity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Mottin

Suyenaga

2018

Int J Dermatology

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“…However, as the pathophysiological mechanisms and underlying processes of the disease advance, new targets emerge for the treatment of AD [5]. Recent studies suggest that the use of probiotics provides benefits in terms of skin health and can help to prevent AD [20][21][22]. Similarly, non-viable bacterial derivatives have been shown to exert antimicrobial and immunomodulating action and can elicit certain immune responses on the skin and improve skin barrier functions [23].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

Crespo¹

2017

PPIJ

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“…These results illustrate the limits of this system, which need to be addressed for a clinical application. While the currently described system is unsuitable for application inside the body, it could be acceptable for skin‐based therapies and cosmetics that would also be able to utilize light‐responsive properties most effectively. Modifying the system to produce other drugs such as cinnamaldehyde and carbapenem that have shown to be optimally synthesized at 37 °C in E. coli and secreted without the requirement of solubilizers could be considered for in vivo clinical applications.…”

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confidence: 99%

Optoregulated Drug Release from an Engineered Living Material: Self‐Replenishing Drug Depots for Long‐Term, Light‐Regulated Delivery

Sankaran

Becker

Wittmann

et al. 2018

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On‐demand and long‐term delivery of drugs are common requirements in many therapeutic applications, not easy to be solved with available smart polymers for drug encapsulation. This work presents a fundamentally different concept to address such scenarios using a self‐replenishing and optogenetically controlled living material. It consists of a hydrogel containing an active endotoxin‐free Escherichia coli strain. The bacteria are metabolically and optogenetically engineered to secrete the antimicrobial and antitumoral drug deoxyviolacein in a light‐regulated manner. The permeable hydrogel matrix sustains a viable and functional bacterial population and permits diffusion and delivery of the synthesized drug to the surrounding medium at quantities regulated by light dose. Using a focused light beam, the site for synthesis and delivery of the drug can be freely defined. The living material is shown to maintain considerable levels of drug production and release for at least 42 days. These results prove the potential and flexibility that living materials containing engineered bacteria can offer for advanced therapeutic applications.

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The effect of probiotics on immune regulation, acne, and photoaging

Cited by 131 publications

References 62 publications

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis

Bacterial Derivatives of Lactococcus lactis and Ectoin for Atopic Dermatitis: Dermal Compatibility and Cosmetic Acceptability

Optoregulated Drug Release from an Engineered Living Material: Self‐Replenishing Drug Depots for Long‐Term, Light‐Regulated Delivery

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