Probiotics and dietary intervention modulate the colonic mucosa-associated microbiota in high-fat diet populations

Qian, Leimin; Huang, Jianming; Qin, Huanlong

doi:10.5152/tjg.2020.19013

Cited by 16 publications

(7 citation statements)

References 29 publications

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“…In contrast to our results, some studies have reported that dietary interventions involving a switch to healthier diets following WD can alleviate gut dysbiosis in rodents [73][74][75] and in humans [76,77]. Our results, however, show an even greater divergence in the microbiome relative to chow-fed rats after switching from either a SUG or a CAF diet to a healthy standard chow diet for ∼5 weeks, especially in the CAF animals.…”

Section: Discussioncontrasting

confidence: 99%

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Hayes

et al. 2021

Nutritional Neuroscience

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Section: Discussioncontrasting

confidence: 99%

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Hayes

et al. 2021

Nutritional Neuroscience

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“…In contrast to our results, some studies have reported that dietary interventions involving a switch to healthier diets following WD can alleviate gut dysbiosis in rodents (Zhang et al, 2012;Shang et al, 2017;Safari et al, 2019) and in humans (Haro et al, 2017;Qian et al, 2020). Our results, however, show an even greater divergence in the microbiome relative to controls after switching from either a SUG or a CAF diet to a healthy control diet for ~5 weeks, especially in the CAF animals.…”

Section: Discussioncontrasting

confidence: 99%

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Bridi

et al. 2021

Preprint

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Objective: Consumption of a Western diet during adolescence results in hippocampus (HPC)- dependent memory impairments and gut microbiome dysbiosis. Whether these adverse outcomes are reversible in adulthood following intervention with a healthy diet is unknown. Here we assessed the short- and long-term effects of adolescent consumption of a Western diet enriched with either sugar alone, or sugar and fat on metabolic outcomes, HPC-dependent memory, and gut microbiota. Methods: Adolescent female rats (PN 26) were fed a standard chow diet (CTL), a chow diet with access to 11% sugar solution (SUG), or a junk food cafeteria-style diet (CAF) containing a variety of fat- and/or sugar-enriched foods. During adulthood (PN 65+), metabolic outcomes, HPC-dependent memory, and gut microbial populations were evaluated both before and after a 5-week dietary intervention period where all groups were fed a diet of water standard chow. Results: Prior to the dietary intervention both the CAF and SUG groups demonstrated impaired HPC-dependent memory, increased adiposity, and altered gut microbial populations relative to controls. However, impaired peripheral glucose regulation was only observed in the SUG group. The dietary intervention reversed the metabolic dysfunction in both the CAF and SUG groups, whereas HPC-dependent memory impairments were reversed in the SUG, but not the CAF group. The composition of the gut microbiota remained distinct from controls in both groups after dietary intervention. Conclusions: While the metabolic impairments associated with adolescent cafeteria diet consumption are reversible in adulthood with dietary intervention, the HPC-dependent memory impairments and the gut microbiome dysbiosis persist.

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“…They were Oxytricha (8.79%↓, p = 0.190), Stylonychia (7.95%↓, p = 0.190), Tetrahymena (5.62%↓, p = 0.190), Paramecium (5.36%↓, p = 0.190), and Trichomonas (5.31%↑, p = 0.383). A study of interventional treatment with probiotics and a low-fat diet on humans showed that the levels of the abovementioned genera except Streptophyta were reduced ( 74 ). Therefore, anthelmintic treatment may affect the digestion of the treated Przewalski's horses.…”

Section: Resultsmentioning

confidence: 99%

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

Yang²,

et al. 2021

Front. Vet. Sci.

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Intestinal microbiota is involved in immune response and metabolism of the host. The frequent use of anthelmintic compounds for parasite expulsion causes disturbance to the equine intestinal microbiota. However, most studies were on the effects of such treatment on the intestinal bacterial microbes; none is on the entire microbial community including archaea and eukaryotic and viral community in equine animals. This study is the first to explore the differences of the microbial community composition and structure in Przewalski's horses prior to and following anthelmintic treatment, and to determine the corresponding changes of their functional attributes based on metagenomic sequencing. Results showed that in archaea, the methanogen of Euryarchaeota was the dominant phylum. Under this phylum, anthelmintic treatment increased the Methanobrevibacter genus and decreased the Methanocorpusculum genus and two other dominant archaea species, Methanocorpusculum labreanum and Methanocorpusculum bavaricum. In bacteria, Firmicutes and Bacteroidetes were the dominant phyla. Anthelmintic treatment increased the genera of Clostridium and Eubacterium and decreased those of Bacteroides and Prevotella and dominant bacteria species. These altered genera were associated with immunity and digestion. In eukaryota, anthelmintic treatment also changed the genera related to digestion and substantially decreased the relative abundances of identified species. In virus, anthelmintic treatment increased the genus of unclassified_d__Viruses and decreased those of unclassified_f__Siphoviridae and unclassified_f__Myoviridae. Most of the identified viral species were classified into phage, which were more sensitive to anthelmintic treatment than other viruses. Furthermore, anthelmintic treatment was found to increase the number of pathogens related to some clinical diseases in horses. The COG and KEGG function analysis showed that the intestinal microbiota of Przewalski's horse mainly participated in the carbohydrate and amino acid metabolism. The anthelmintic treatment did not change their overall function; however, it displaced the population of the functional microbes involved in each function or pathway. These results provide a complete view on the changes caused by anthelmintic treatment in the intestinal microbiota of the Przewalski's horses.

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Probiotics and dietary intervention modulate the colonic mucosa-associated microbiota in high-fat diet populations

Cited by 16 publications

References 29 publications

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Metagenomic Analysis of Fecal Archaea, Bacteria, Eukaryota, and Virus in Przewalski's Horses Following Anthelmintic Treatment

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