Probiotics and clinical effects: is the number what counts?

Bertazzoni, E. Minelli; Donelli, Gianfranco; Midtvedt, Tore; Nicoli, Jacques R.; Sanz, Yolanda

doi:10.1179/1973947813y.0000000078

Cited by 67 publications

(48 citation statements)

References 153 publications

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“…During the 30 days of protocol, the fermented probiotic product showed more than 9 logCFU/g of the three organisms analyzed, which is considered appropriate for them to exert their probiotic effects [51,52]. …”

Section: Resultsmentioning

confidence: 99%

Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

et al. 2017

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BackgroundSome probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within a period of 30 days.MethodsColitis was induced by dextran sulfate sodium. The animals were randomly assigned into five groups: Group C: negative control; Group CL: positive control; Group CLF: DSS with the fermented product; Group CLP: DSS with the non-fermented product (placebo); Group CLS: DSS with sulfasalazine. The following parameters were monitored: disease activity index, fecal microbial analyses, gastrointestinal survival of probiotic microorganisms and short-chain fatty acids concentration in the feces. At the end of the protocol the animals’ colons were removed so as to conduct a macroscopical and histopathological analysis, cytokines and nitrite quantification.ResultsAnimals belonging to the CLF group showed fewer symptoms of colitis during the induction period and a lower degree of inflammation and ulceration in their colon compared to the CL, CLS and CLP groups (p<0.05). The colon of the animals in groups CL and CLS presented severe crypt damage, which was absent in CLF and CLP groups. A significant increase in the population of Lactobacillus spp. and Bifidobacterium spp. at the end of the protocol was verified only in the CLF animals (p<0.05). This group also showed an increase in short-chain fatty acids (propionate and acetate). Furthermore, the intestinal survival of E. faecium CRL 183 and B. longum ATCC 15707 in the CLF group has been confirmed by biochemical and molecular analyzes.ConclusionsThe obtained results suggest that a regular intake of the probiotic product, and placebo to a lesser extent, can reduce the severity of DSS-induced colitis on rats.

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Section: Resultsmentioning

confidence: 99%

Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

et al. 2017

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“…A review by Bertazzoni et al 27 concluded that a probiotic treatment should be designed around the dose–effect relationships established in humans. In 2012, Mihatsch et al 28 systematically analysed the level of evidence in 15 published RCTs on probiotics in preterm infants and concluded that there was insufficient evidence to base a general recommendation for routine use of probiotics in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Dose-interval study of a dual probiotic in preterm infants

Watkins

Murphy

Dempsey

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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“…Probiotics are defined as live microorganisms, which colonize the gut and promote benefits to host health [110,111,112,113,114,115]. Prebiotics can modulate the structure and metabolism of beneficial microbes in the colon and improve host health [116,117,118,119].…”

Section: Intestinal Microbiome Targeting Strategiesmentioning

confidence: 99%

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

Yang

Wang

et al. 2016

IJMS

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Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the sacroiliac joints and the spine, for which the pathogenesis is thought to be a result of the combination of host genetic factors and environmental triggers. However, the precise factors that determine one’s susceptibility to AS remain to be unraveled. With 100 trillion bacteria residing in the mammalian gut having established a symbiotic relation with their host influencing many aspects of host metabolism, physiology, and immunity, a growing body of evidence suggests that intestinal microbiota may play an important role in AS. Several mechanisms have been suggested to explain the potential role of the microbiome in the etiology of AS, such as alterations of intestinal permeability, stimulation of immune responses, and molecular mimicry. In this review, the existing evidence for the involvement of the microbiome in AS pathogenesis was discussed and the potential of intestinal microbiome-targeting strategies in the prevention and treatment of AS was evaluated.

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Probiotics and clinical effects: is the number what counts?

Cited by 67 publications

References 153 publications

Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

Dose-interval study of a dual probiotic in preterm infants

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

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