Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being

Okesene-Gafa, Karaponi; Moore, Abigail E.; Jordan, Vanessa; McCowan, Lesley; Crowther, Caroline A

doi:10.1002/14651858.cd012970.pub2

Cited by 21 publications

(19 citation statements)

References 70 publications

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“…Gestational diabetes mellitus (GDM) is a type of diabetes that is diagnosed in the second or third trimester of pregnancy [ 13 ] and remains a common and increasing complication of pregnancy [ 14 ]. Women with GDM are at risk of high blood pressure, labour induction, or unnecessary caesarean delivery [ 15 , 16 ]. In addition, GDM is associated with infant risks, such as macrosomia, respiratory distress syndrome, birth injuries, bone fractures and shoulder dystocia, jaundice, and hypoglycaemia, thus endangering the child’s health [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

et al. 2021

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Diabetes mellitus has been steadily increasing over the past decades and is one of the most significant global public health concerns. Diabetes mellitus patients have an increased risk of both surgical and post-surgical complications. The post-surgical risks are associated with the primary condition that led to surgery and the hyperglycaemia per se. Gut microbiota seems to contribute to glucose homeostasis and insulin resistance. It affects the metabolism through body weight and energy homeostasis, integrating the peripheral and central food intake regulatory signals. Homeostasis of gut microbiota seems to be enhanced by probiotics pre and postoperatively. The term probiotics is used to describe some species of live microorganisms that, when administered in adequate amounts, confer health benefits on the host. The role of probiotics in intestinal or microbial skin balance after abdominal or soft tissue elective surgeries on DM patients seems beneficial, as it promotes anti-inflammatory cytokine production while increasing the wound-healing process. This review article aims to present the interrelation of probiotic supplements with DM patients undergoing elective surgeries.

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Section: Resultsmentioning

confidence: 99%

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

et al. 2021

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“…Animal studies have shown that high Fru intake promotes GDM development and alters glucose metabolism in maternal females and offspring, although the mechanisms underlying these effects have been poorly defined. Increasing evidence indicates that IR is a chronic inflammatory process ( 6 , 7 ). Inflammatory factors such as TNF-α, IL-6, and CRP have been proven to be independent risk factors for IR.…”

Section: Discussionmentioning

confidence: 99%

“…Recent in-depth studies of the insulin signaling pathway have revealed the importance of inflammation in abnormal glucose metabolism. For example, inflammatory factors such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) have been reported to contribute to IR in GDM ( 6 , 7 ). The nucleotide-binding oligomerization domain-like receptor (NLRP3) inflammasome is a macromolecular polyprotein complex composed of NLRP3, the apoptosis-associated speck-like protein containing caspase recruitment domain (ASC) and cysteinyl aspartate specific proteinase-1 (caspase-1) ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway

Liu

Wei

et al. 2022

Front. Nutr.

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BackgroundInsulin resistance (IR), which is affected by dietary factors, is the main pathology underlying of gestational diabetes mellitus (GDM). Fructose (Fru), a sugar found in fruits, honey, and food sweeteners, has been reported to induce IR and inflammation. This study explored the effects and mechanisms of Fru on IR of GDM in pregnant and postpartum mice and their offspring.MethodsThe 6-week-old female C57BL/6J mice were randomly divided into control (Chow) and fructose (Fru) groups, with the latter receiving 20% (w/v) Fru in drinking water from 2 weeks before pregnancy to the end of pregnancy. The effects of Fru on IR and inflammation were determined using serum parameters, glucose metabolism tests, immunohistochemistry, and western blotting.ResultsCompared with the Chow group mice, pregnant mice treated with Fru exhibited greater gestational weight gain, higher fasting blood glucose and insulin concentrations, and a higher homeostasis model of assessment (HOMA) for IR index, but a lower HOMA for insulin sensitivity index. Treatment with Fru also increased the concentrations of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), IL-17, and C-reactive protein in sera and the expression of IL-6, TNF-α, IL-17, and IL-1β mRNA in liver tissues of pregnant mice. Both CD68 and IL-1β positive cell were increased in Fru-treated mice compared with in Chow mice. Fru treatment also promoted IR and inflammation in mice at 4 weeks after delivery and in offspring mice. Mechanistically, Fru promoted the nuclear translocation of nuclear factor-kappa B (NF-κB) p65 to activate the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome.ConclusionsExposure to Fru before and during pregnancy induced IR in pregnant mice, which continued at 4 weeks postpartum and affected the offspring. The effects of Fru may be associated with activation of the NF-κB–NLRP3 pathway.

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“…However, the exact mechanisms by which probiotics may affect GDM remain unknown. Furthermore, some studies have shown no evidence that probiotics administration decreases the risk of GDM any more than placebos [126] , [127] , and another study suggests that probiotics ( L. rhamnosus and B. animalis subspecies lactis ) had limited ability to prevent GDM in overweight and obese pregnant women [128] . Effects of microbiomes and probiotics on female reproduction were briefly summarized in Table 2 .…”

Section: Female Reproductive Microbiomementioning

confidence: 99%

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

Feng

Liu

2022

Computational and Structural Biotechnology Journal

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Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being

Cited by 21 publications

References 70 publications

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway

Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health

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