Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects

Soleimani, Alireza; Mojarrad, Malihe Zarrati; Bahmani, Fereshteh; Taghizadeh, Mohsen; Ramezani, Mohammad; Tajabadi‐Ebrahimi, Maryam; Jafari, Parvaneh; Esmaillzadeh, Ahmad; Asemi, Zatollah

doi:10.1016/j.kint.2016.09.040

Cited by 153 publications

(178 citation statements)

References 48 publications

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“…The subgroup analysis of two studies on non‐dialysis patients displayed that probiotic supplements significantly reduced urea (MD = −30.01; 95% CI = [−56.78, −3.25]; P = 0.03), with high heterogeneity ( P = 0.08; I 2 = 68%). In the four studies, on dialysis patients, the subgroup analysis exhibited no significant difference between probiotics and placebo (MD = 0.1; 95% CI = [−9.28, 9.48], P = 0.98), with no heterogeneity ( P = 0.65, I 2 = 0%) (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

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Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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Background Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here, we performed a meta‐analysis to assess the effects of probiotic supplements on the CKD progression. Methods A systematic search was conducted through the PubMed, Embase and Cochrane databases until September 2018. Randomized controlled trials with control receiving placebo, evaluating the effects of probiotic supplements on CKD were included. Results A total of 10 randomized controlled trials in 8 countries were selected. In the meta‐analysis, urea level was significantly reduced in probiotics‐administrated non‐dialysis patients (mean differences (MD) = −30.01; 95% confidence interval (CI) = [−56.78, −3.25]; P = 0.03) while no significant change was found in the dialysis patients receiving probiotics (MD = 0.1; 95% CI = [−9.28, 9.48]; P = 0.98). Probiotic supplements also exhibited no effect on uric acid (MD = −0.43; 95% CI = [−1.19, 0.33]; P = 0.27), C‐reactive protein (MD = −0.48; 95% CI = [−1.29, 0.33]; P = 0.24), creatinine (MD = −0.18; 95% CI = [−0.82, 0.47]; P = 0.59), and estimated glomerular filtration rate (MD = 2.10; 95% CI = [−1.31, 5.52]; P = 0.23) of CKD patients. Conclusion Our results highlighted that probiotic supplements exerted a statistically significant effect on urea levels in non‐dialysis CKD population, while no evidence suggested that probiotics possessed meaningful impacts on the reduction of uric acid, C‐reactive protein, creatinine and estimated glomerular filtration rate preservation of CKD population.

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Section: Resultsmentioning

confidence: 99%

“…In the meta‐analysis, six of the included studies reported the changes in serum creatinine level. Heterogeneity of the six studies was significant ( P = 0.006, I 2 = 69%).…”

Section: Resultsmentioning

confidence: 99%

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

et al. 2019

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“…In our study, the findings of an antioxidative effect of the synbiotic supplement were in line with previous studies. Soleimani et al showed that probiotic supplementation for 12 weeks among diabetic hemodialysis patients reduced levels of some inflammation biomarkers as well as markers of oxidative stress such as MDA. In another study, consumption of bread containing a synbiotic bread for 8 weeks by patients with T2DM decreased plasma MDA levels; however, it did not affect plasma total antioxidant capacity, glutathione, or catalase levels .…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the findings of an antioxidative effect of the synbiotic supplement were in line with previous studies. Soleimani et al 35 showed that probiotic supplementation for 12 weeks among diabetic hemodialysis patients reduced levels of some inflammation biomarkers as well as markers of oxidative stress such as MDA. In another study, consumption of bread containing 36 In the study by Suo et al, it was found that a probiotic supplement containing Lactobacillus fermentum) reduced MDA activity in mice with gastric injury.…”

Section: Discussionmentioning

confidence: 99%

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Kooshki

Tofighiyan

Miri

2019

Hemodialysis International

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Introduction: Among the most important risk factors for cardiovascular disease in hemodialysis patients are high concentrations of serum inflammation markers, lipid profiles, and oxidative stress. The present study aimed to investigate the effects of a synbiotic supplement on serum systemic inflammation, oxidative stress markers, and lipid profile in hemodialysis patients. Methods: Fifty hemodialysis patients were randomly allocated to synbiotic and placebo groups. The synbiotic group received 2 tablets per day of a synbiotic supplement (100 mg) Lactobacillus coagulans and fructo‐oligosaccharides for 8 weeks; whereas the placebo group received a similar appearing placebo. At the beginning and end of the study, 5 mL blood was taken after 12–14 hours of fasting. Findings: Mean values of serum C‐reactive protein (hs‐CRP) and malondialdehyde (MDA) significantly decreased in the synbiotic group at the end compared to the beginning of the study (P = 0.01). This reduction was significant in comparison with changes in the placebo group (P = 0.01). The synbiotic supplement also reduced serum total cholesterol (P = 0.001) and low‐density lipoprotein cholesterol (LDL‐c; P = 0.001) compared to the placebo group. Discussion: The synbiotic supplement used improves serum hs‐CRP and MDA, total cholesterol and LDL‐c in hemodialysis patients, which are known risk factors for cardiovascular disease.

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“…Despite its benefits, pharmacotherapy may result in significant side effects including abdominal discomfort, dizziness, diarrhea and hypoglycemia [22]. As research suggests that probiotic interventions may attenuate some of the adverse metabolic effects of type 2 diabetes [23,24], probiotics may also provide an acceptable treatment option in women with GDM.…”

Section: Introductionmentioning

confidence: 99%

Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2017

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The metabolic effects of probiotic administration in women with gestational diabetes mellitus (GDM) is unknown. The objective of this review was to investigate the effect of probiotics on fasting plasma glucose (FPG), insulin resistance (HOMA-IR) and LDL-cholesterol levels in pregnant women diagnosed with GDM. Seven electronic databases were searched for RCTs published in English between 2001 and 2017 investigating the metabolic effects of a 6–8 week dietary probiotic intervention in pregnant women following diagnosis with GDM. Eligible studies were assessed for risk of bias and subjected to qualitative and quantitative synthesis using a random effects model meta-analyses. Four high quality RCTs involving 288 participants were included in the review. Probiotic supplementation was not effective in decreasing FBG (Mean Difference = −0.13; 95% CI −0.32, 0.06, p = 0.18) or LDL-cholesterol (−0.16; 95% CI −0.45, 0.13, p = 0.67) in women with GDM. However, a significant reduction in HOMA-IR was observed following probiotic supplementation (−0.69; 95% CI −1.24, −0.14, p = 0.01). There were no significant differences in gestational weight gain, delivery method or neonatal outcomes between experimental and control groups, and no adverse effects of the probiotics were reported. Probiotic supplementation for 6–8 weeks resulted in a significant reduction in insulin resistance in pregnant women diagnosed with GDM. The use of probiotic supplementation is promising as a potential therapy to assist in the metabolic management of GDM. Further high quality studies of longer duration are required to determine the safety, optimal dose and ideal bacterial composition of probiotics before their routine use can be recommended in this patient group.

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Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects

Cited by 153 publications

References 48 publications

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

Effects of probiotic supplements on the progression of chronic kidney disease: A meta‐analysis

A synbiotic supplement for inflammation and oxidative stress and lipid abnormalities in hemodialysis patients

Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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