Probiotic Supplementation for Prevention of Atopic Dermatitis in Infants and Children: A Systematic Review and Meta-analysis

Li, Lin; Zhen, Han; Niu, Xiaoping; Zhang, Guozheng; Jia, Yuliang; Zhang, Shunguo; He, Chuanchao

doi:10.1007/s40257-018-0404-3

Cited by 94 publications

(79 citation statements)

References 44 publications

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“…Elazab et al found that pre‐ and/or early‐life antibiotic administration reduced atopic sensitization (as measured by skin prick test). A later systematic review and meta‐analysis demonstrated that probiotic supplementation in both the pre‐ and postnatal period reduced the incidence of pediatric AD . In contrast, probiotics do not appear to be beneficial in treatment of pediatric AD .…”

Section: Introductionmentioning

confidence: 99%

The infantile cutaneous microbiome: A review

Schoch

Monir

Satcher

et al. 2019

Pediatric Dermatology

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Recent focus on the neonatal intestinal microbiome has advanced our knowledge of the complex interplay between the intestinal barrier, the developing immune system, and commensal and pathogenic organisms. Despite the parallel role of the infant skin in serving as both a barrier and an interface for priming the immune system, large gaps exist in our understanding of the infantile cutaneous microbiome. The skin microbiome changes and matures throughout infancy, becoming more diverse and developing the site specificity known to exist in adults. Delivery method initially determines the composition of the cutaneous microbiome, though this impact appears transient. Cutaneous microbes play a critical role in immune system development, particularly during the neonatal period, and microbes and immune cells have closely intertwined, reciprocal effects. The unique structure of newborn skin influences cutaneous microbial colonization and the development of dermatologic pathology. The development of the infantile skin barrier and cutaneous microbiome contributes to future skin pathology. Atopic dermatitis flares and seborrheic dermatitis have been linked to dysbiosis, while erythema toxicum neonatorum is an immune response to the establishment of normal bacterial skin flora. Physicians who care for infants should be aware of the impact of the infantile skin microbiome and its role in the development of pathology. A better understanding of the origin and evolution of the skin microbiome will lead to more effective prevention and treatment of pediatric skin disease.

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Section: Introductionmentioning

confidence: 99%

The infantile cutaneous microbiome: A review

Schoch

Monir

Satcher

et al. 2019

Pediatric Dermatology

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“…They found mixtures of probiotics including L ., Bifidobacterium and Propionibacterium strains reduced the risk of developing AD from gestation and continuing through the first 6 months of infant's life. However, this review did not perform sub‐meta‐analyses on the method of supplementation, population and probiotic strains supplemented …”

Section: Discussionmentioning

confidence: 99%

“…Interest in the area of probiotic supplementation and its potential role in the prevention of AD has increased especially over the past 5 years where many studies have been undertaken in this area. Since 2012, there have been four systematic reviews, with the latest review published in 2018 . These reviews have also completed meta‐analysis; however, while probiotics have shown to decrease the risk of developing AD, there has been no definite answer on the best method of supplementation and the specific strain/s needed to enhance this outcome.…”

Section: Introductionmentioning

confidence: 99%

Systematic review and meta‐analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children

et al. 2019

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“…Some reports show an enormous benefit associated with the use of probiotics in AD prevention and treatment. These studies show inconsistent results and require to be confirmed [32][33][34][35][36].…”

Section: Probioticsmentioning

confidence: 96%

Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part II. Systemic treatment and new therapeutic methods

Nowicki¹,

Trzeciak²,

Kaczmarski³

et al. 2019

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The treatment goal in atopic dermatitis is eliminating clinical symptoms of the disease, preventing exacerbations and complications, as well as improving patients' quality of life. In cases of severe atopic dermatitis and lack of response it is recommended to introduce systemic therapy. Patients ofter require multi-specialist consultations, and occasionally hospitalization. It is not recommended to use acupuncture, acupressure, bioresonance, homeopathy, or Chinese herbs in the treatment of atopic dermatitis. STReSZCZeNIe Terapia atopowego zapalenia skóry powinna skutecznie eliminować kliniczne objawy choroby, zapobiegać zaostrzeniom i powikłaniom oraz poprawiać jakość życia pacjentów. W przypadku atopowego zapalenia skóry o ciężkim przebiegu i przy braku poprawy po leczeniu miejscowym zaleca się rozważenie włączenia terapii ogólnej. Pacjenci wymagają częstych konsultacji wielospecjalistycznych, a niekiedy hospitalizacji. W leczeniu atopowego zapalenia skóry nie zaleca się akupunktury, akupresury, biorezonansu, homeopatii oraz ziół chińskich.

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Probiotic Supplementation for Prevention of Atopic Dermatitis in Infants and Children: A Systematic Review and Meta-analysis

Cited by 94 publications

References 44 publications

The infantile cutaneous microbiome: A review

The infantile cutaneous microbiome: A review

Systematic review and meta‐analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children

Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part II. Systemic treatment and new therapeutic methods

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