Systematic review and meta‐analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children

Abstract

Probiotic supplementation may decrease the risk of allergic disease; however, there are differences between studies, such as the type of probiotic, the route or the duration of supplementation. Therefore, determining the most effective probiotic strain/s,

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

“…51 A new Cochrane systematic review and meta-analysis of 21 studies issued the recommendation that a mixture of probiotic supplementation given to the mother during pregnancy and continued, while breastfeeding would be most efficacious in reducing the risk of incidence of AD in children. 52,53 The ETFAD does not give a recommendation for any dietary and lifestyle changes aiming at primary prevention of AD, because the quality of data is not sufficient to issue a sustainable recommendation for any of the interventions studied.…”

“…A diagnosis of AD is associated with a decreased diversity of neonates’ gut microbiota 51 . A new Cochrane systematic review and meta‐analysis of 21 studies issued the recommendation that a mixture of probiotic supplementation given to the mother during pregnancy and continued, while breastfeeding would be most efficacious in reducing the risk of incidence of AD in children 52,53 …”

COVID-19 multidisciplinary working group

“…Among them were 463 who had MCH amounting to ≤28 pg vs 209 with MCV of ≤80 fL. 2 Accordingly, given the fact that MCH of ≥28 pg is more prevalent than MCV of ≤80 fL in IDWA subjects, a MCH of <28 pg should be a red flag for IDWA, prompting further investigation along the lines proposed by Al-Naseem et al 3 The recognition of IDWA has implications for correction of incident iron deficiency and for identification of its underlying cause. Correction of incident iron deficiency (regardless of Hb level) is a matter of urgency in patients with congestive heart failure (CHF).…”

“…4 Furthermore, among CHF patients in whom iron deficiency has been defined according to the criteria cited by Al-Naseem et al, treatment with intravenous iron improves symptoms, functional capacity and quality of life irrespective of presence or absence of anaemia. 3,5 The rationale for these outcomes might be the one that comes from animal studies. [4][5][6][7] In one study, IDWA was shown to be responsible for decreased left ventricular function and reduced mitochondrial complex 1 activity in mice.…”

“…8 In a separate study (a retrospective analysis not included in the previous meta-analysis), among 287 CHF patients of mean age 70 years with IDWA, 30 were diagnosed with gastrointestinal malignancies. 9 In the latter study, anaemia was defined as Hb <12 g/dL in both men and women, and iron deficiency was defined according to the criteria cited by Al-Naseem et al 3 In that study, serum ferritin <30 μg/L had a specificity of 90% for generating a positive endoscopy result but this was at the cost of poor sensitivity (13%), in other words, at the cost of rejecting many potential candidates for endoscopy simply because they had higher serum ferritin values. Conversely, a serum ferritin cut-off level of <100 μg/L had higher sensitivity (93%) in identifying potential candidates for endoscopy but at the cost of a higher ratio of 'numbers needed to endoscope' (ie lower specificity, amounting to 31%) for obtaining a positive endoscopy result.…”