Probiotic sepsis due to <i>Saccharomyces</i> fungaemia in a critically ill burn patient

Stefanatou, Eleni; Kompoti, Maria; Paridou, Alexandra; Koutsodimitropoulos, Ioannis; Giannopoulou, Panagiota; Μάρκου, Νικόλαος; Kalofonou, M.; Trikka-Graphakos, Eleftheria; Tsidemiadou, F

doi:10.1111/j.1439-0507.2010.01963.x

Cited by 22 publications

(11 citation statements)

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“…Colonization by commensals can protect against pathogens, though the same bacteria can cause disease in particular circumstances, as observed with, for example, the skin commensals Staphylococcus aureus and Propionibacterium acnes [5]. Likewise, colonization by probiotic yeasts is regarded as beneficial, but can, in particular cases, cause infections: fungemia caused by Saccharomyces cerevisiae and S. boulardii have both been described [6–8]. Whether the outcome of colonization is disease or a commensal relationship is defined by a combination of factors, of which the genetic properties of the bacteria are not the only ones: genetic and immunological factors of the host, as well as the presence of other microbiota are also contributing.…”

Section: Correspondencementioning

confidence: 99%

The prediction of virulence based on presence of virulence genes in E. coli may not always be accurate

Wassenaar

Gunzer

2015

Gut Pathog

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Now that microbial whole genome sequencing is in reach of many researchers, it is common to infer virulent properties of a given bacterial isolate based on the presence of virulence genes. However, this may lead to inaccurate presumptions of virulence. Using the findings of a recent publication (Da Silva Santos et al. Gut Pathog 7:2, 2015) where virulence was inferred from a genome sequence and subsequently confirmed by in vitro analysis, we present an alternative view on the case described in that publication. Our alternative view point, which is further substantiated by whole genome sequencing of probiotic E. coli strains, may contribute to a more balanced vision on the interactions between pathogens and host.

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Section: Correspondencementioning

confidence: 99%

The prediction of virulence based on presence of virulence genes in E. coli may not always be accurate

Wassenaar

Gunzer

2015

Gut Pathog

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“…septicemia in a 600 gm infant who was being fed the probiotics (Infloran). There have also been reports of septicemia related to probiotic use in immunocompromised critically ill adult [51, 52]. Lactobacillus and Bifidobacterium are anaerobic microorganisms that require special culture techniques.…”

Section: Safety Of Probioticsmentioning

confidence: 99%

Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants

Nair

Soraisham

2013

International Journal of Pediatrics

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Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants.

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“…Candida albicans is the species most frequently isolated in major burn patients with fungal infection, even though some recent series have pointed to the predominance of non‐ albicans species . In addition to disseminated candidiasis, other invasive infections such as trichosporonosis, geotrichosis and saccharomycosis have been reported in these patients as well as infections by filamentous fungi ( Aspergillus , Fusarium and Mucor, among others) …”

Section: Introductionmentioning

confidence: 99%

Candidemia in major burns patients

Escrig

Salavert

Vivo

et al. 2016

Mycoses

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Major burn patients have characteristics that make them especially susceptible to candidemia, but few studies focused on this have been published. The objectives were to evaluate the epidemiological, microbiological and clinical aspects of candidemia in major burn patients, determining factors associated with a poorer prognosis and mortality. We conducted a retrospective observational study of candidemia between 1996 and 2012 in major burn patients admitted to the La Fe University Hospital, Valencia, Spain. The study included 36 episodes of candidemia in the same number of patients, 55.6% men, mean age 37.33 years and low associated comorbidity. The incidence of candidemia varied between 0.26 and 6.09 episodes/1000 days stay in the different years studied. Candida albicans was the most common species (61.1%) followed by Candida parapsilosis (27.8%). Candidemia by C. krusei, C. glabrata or C. tropicalis were all identified after 2004. Central vascular catheter (CVC) was established as a potential source of candidemia in 36.1%, followed by skin and soft tissues of thermal injury (22.2%) and urinary tract (8.3%). Fluconazole was used in 19 patients (52.7%) and its in vitro resistance rate was 13.9%. The overall mortality was 47.2%, and mortality related to candidemia was 30.6%. Factors associated with increased mortality were those related to severe infection and shock. CVC was the most usual focus of candidemia. Fluconazole was the most common antifungal drug administered. The management of candidemia in major burn patients is still a challenge.

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Probiotic sepsis due to Saccharomyces fungaemia in a critically ill burn patient

Cited by 22 publications

References 0 publications

The prediction of virulence based on presence of virulence genes in E. coli may not always be accurate

The prediction of virulence based on presence of virulence genes in E. coli may not always be accurate

Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants

Candidemia in major burns patients

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