Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation

Kusumo, Pratiwi Dyah; Maulahela, Hasan; Utari, Amanda Pitarini; Surono, Ingrid S.; Soebandrio, Amin; Abdullah, Murdani

doi:10.18502/ijm.v11i5.1957

Cited by 16 publications

(16 citation statements)

References 32 publications

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“…Given the role of metabolites in autoimmune diseases, one proposed therapeutic strategy is to promote generation of SCFAs in the gut in order to impel the differentiation of naïve CD4+ T-cells into Treg cells, avoiding differentiation into Th1 and Th17 cells. One may support the growth and proliferation of SCFA-producing gut microbes by using appropriate types of dietary fiber [ 143 ], prebiotics such as fructo-oligosaccharides [ 144 , 145 ], or probiotics [ 146 ]. Oral delivery of SCFAs may be problematic as they are metabolized extensively in the upper portions of the intestinal tract [ 147 ].…”

Section: Dysbiosis Of the Gut Microbiota And Related Diseasesmentioning

confidence: 99%

Gut Microbiota and Immune System Interactions

et al. 2020

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Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems play key roles in maintaining intestinal homeostasis and inhibiting inflammation. The gut microbiota metabolizes proteins and complex carbohydrates, synthesize vitamins, and produce an enormous number of metabolic products that can mediate cross-talk between gut epithelial and immune cells. As a defense mechanism, gut epithelial cells produce a mucosal barrier to segregate microbiota from host immune cells and reduce intestinal permeability. An impaired interaction between gut microbiota and the mucosal immune system can lead to an increased abundance of potentially pathogenic gram-negative bacteria and their associated metabolic changes, disrupting the epithelial barrier and increasing susceptibility to infections. Gut dysbiosis, or negative alterations in gut microbial composition, can also dysregulate immune responses, causing inflammation, oxidative stress, and insulin resistance. Over time, chronic dysbiosis and the translocation of bacteria and their metabolic products across the mucosal barrier may increase prevalence of type 2 diabetes, cardiovascular disease, inflammatory bowel disease, autoimmune disease, and a variety of cancers. In this paper, we highlight the pivotal role gut microbiota and their metabolites (short-chain fatty acids (SCFAs)) play in mucosal immunity.

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Section: Dysbiosis Of the Gut Microbiota And Related Diseasesmentioning

confidence: 99%

Gut Microbiota and Immune System Interactions

et al. 2020

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“…The second type is commensal microflora or beneficial bacteria, for example, probiotics. Studies show that sIgA can help get rid of harmful microbes and reshape the gut ecology by increasing the beneficial microbes (Kusumo, Maulahela, et al., 2019 , 2019 , 2019 , 2019 ). It is possible to deal with low or high sIgA levels through intake of the beneficial microbes via symbiotic products.…”

Section: Resultsmentioning

confidence: 99%

“…Probiotics contain live beneficial microbes that can improve digestive health. The probiotic Lactobacillus plantarum was reported to influence human gut health such as (Kusumo, Maulahela, et al., 2019 , 2019 , 2019 , 2019 ) improving the mucosal immune function and helping against pathogens such as Clostridia spp. It also helps in balancing the gut microbiota by producing short‐chain fatty acids as an energy source to maintain the gut's ecosystem and physiology.…”

Section: Introductionmentioning

confidence: 99%

A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double‐blind randomized controlled clinical trial

Liao¹,

Su²,

Zhang³

2022

Food Science & Nutrition

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Several studies have claimed that the consumption of fermented dairy products can improve human gastrointestinal (GI) health. However, the numbers of systematic clinic trials are limited. In this study, a yogurt containing both probiotics and prebiotics was developed and a double‐blind randomized controlled clinical trial was carried out to evaluate the effect of the product on human gastrointestinal health in three different aspects: (1) the effect on functional constipation (FC) and functional diarrhea (FD); (2) the effect on gastrointestinal (GI) tract immune system; and (3) the changes in GI tract microbiota. Participants who suffered FC or FD were randomized into three groups (n = 66 each group): the first group was treated with fermented milk with Lactobacillus plantarum ST‐III (7 mg/kg) and inulin (1.5%), the second group was treated with L. plantarum ST‐III (7 mg/kg) and inulin (1.0%), and the third group (control group) was treated without probiotics and prebiotics. Half of the participants stopped the treatment after 14 days and the rest of the group continued the trial to the full 28 days. The fecal samples of participants were analyzed regarding their short‐chain fatty acids (SCFAs), secretory immunoglobulin A (sIgA), and microbiota. A survey on GI tract health was conducted and the Bristol stool scale was recorded. The results showed that the consumption of the symbiotic yogurt for 14 days and 28 days can both improve the digestive system, with the continual consumption of product containing L. plantarum ST‐III (7 mg/kg) and inulin (1.5%) for 28 days showing the most significance. The consumption of this product may be used as a potential functional food.

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“…Acetate is the most abundant and it is used by many gut commensals to produce propionate and butyrate in a growth-promoting cross-feeding process ( 84 ). A randomized double-blind show that probiotic L. plantarum IS 10506 supplementation significantly influenced acetate titer, but marginally significant for propionate and butyrate of women with functional constipation in the community of Jakarta ( 85 ).…”

Section: Probiotics Diversely Involved In Lipid Metabolism To Improve...mentioning

confidence: 99%

Probiotics Interact With Lipids Metabolism and Affect Gut Health

Wang

Xiong

et al. 2022

Front. Nutr.

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Probiotics have attracted much attention due to their ability to modulate host intestinal microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel disease (IBD) and bowel cancer are digestive system disease, which have become a global public health problem due to their unclear etiology, difficult to cure, and repeated attacks. Disturbed gut microbiota and abnormal lipid metabolism would increase the risk of intestinal inflammation. However, the link between lipid metabolism, probiotics, and IBD is unclear. In this review, we found that different lipids and their derivatives have different effects on IBD and gut microbes. ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid, eicosapentaenoic acid, and their derivatives resolvin E1, resolvin D can inhibit oxidative stress and reactive oxygen species activate NFκB and MAPk pathway. While ω-6 PUFAs linoleic acid and arachidonic acid can be derived into leukotrienes and prostaglandins, which will aggravate IBD. Cholesterol can be converted into bile acids to promote lipid absorption and affect microbial survival and colonization. At the same time, it is affected by microbial bile salt hydrolase to regulate blood lipids. Low denstiy lipoprotein (LDL) is easily converted into oxidized LDL, thereby promoting inflammation, while high denstiy lipoprotein (HDL) has the opposite effect. Probiotics compete with intestinal microorganisms for nutrients or ecological sites and thus affect the structure of intestinal microbiota. Moreover, microbial short chain fatty acids, bile salt hydrolase, superoxide dismutase, glutathione, etc. can affect lipid metabolism and IBD. In conclusion, probiotics are directly or indirectly involved in lipids metabolism and their impact on IBD, which provides the possibility to explore the role of probiotics in improving gut health.

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Probiotic Lactobacillus plantarum IS 10506 supplementation increase SCFA of women with functional constipation

Cited by 16 publications

References 32 publications

Gut Microbiota and Immune System Interactions

Gut Microbiota and Immune System Interactions

A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double‐blind randomized controlled clinical trial

Probiotics Interact With Lipids Metabolism and Affect Gut Health

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