Probiotic
            <i>Lactiplantibacillus plantarum</i>
            N‐1 could prevent ethylene glycol‐induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function

Wei, Zhitao; Cui, Yaqian; Tian, Lei; Liu, Yu; Yu, Yang; Jin, Xi; Li, Hong; Wang, Kunjie; Sun, Qun

doi:10.1096/fj.202100887rr

Cited by 27 publications

(23 citation statements)

References 49 publications

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“…Additionally, they showed increased production of short-chain fatty acids (SCFA) and an abundance of beneficial SCFA-producing bacteria, mainly from the Lachnospiraceae and Ruminococcaceae families. As such, it was observed that the LPN1 probiotic can prevent ethylene glycol-induced hyperoxaluria by regulating the gut microflora and improving gut barrier function [ 90 ].…”

Section: Lactobacillus Sppmentioning

confidence: 99%

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Wigner

Bijak

Saluk‐Bijak

2022

Cells

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Nephrolithiasis ranks third among urological diseases in terms of prevalence, making up about 15% of cases. The continued increase in the incidence of nephrolithiasis is most probably due to changes in eating habits (high protein, sodium, and sugar diets) and lifestyle (reduced physical activity) in all developed countries. Some 80% of all kidney stones cases are oxalate urolithiasis, which is also characterized by the highest risk of recurrence. Frequent relapses of nephrolithiasis contribute to severe complications and high treatment costs. Unfortunately, there is no known effective way to prevent urolithiasis at present. In cases of diet-related urolithiasis, dietary changes may prevent recurrence. However, in some patients, the condition is unrelated to diet; in such cases, there is evidence to support the use of stone-related medications. Interestingly, a growing body of evidence indicates the potential of the microbiome to reduce the risk of developing renal colic. Previous studies have primarily focused on the use of Oxalobacterformigenes in patients with urolithiasis. Unfortunately, this bacterium is not an ideal probiotic due to its antibiotic sensitivity and low pH. Therefore, subsequent studies sought to find bacteria which are capable of oxalate degradation, focusing on well-known probiotics including Lactobacillus and Bifidobacterium strains, Eubacterium lentum, Enterococcus faecalis, and Escherichia coli.

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Section: Lactobacillus Sppmentioning

confidence: 99%

Probiotics in the Prevention of the Calcium Oxalate Urolithiasis

Wigner

Bijak

Saluk‐Bijak

2022

Cells

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“…plantarum strains 39,40 but also L . plantarum without genetic modification can slow down the inflammation levels and reduce the content of urinary oxalic acid and the formation of kidney stones 8,41 . Even L .…”

Section: Introductionmentioning

confidence: 99%

“…At present, the major metabolites studied are short-chain fatty acids (SCFAs) and arginine. 8,41,42 Hence, we investigated L. plantarum J-15 isolated from healthy human feces to explore whether L. plantarum J-15 can reduce the formation of kidney crystals and affects inflammation levels and intestinal barrier function. The association between intestinal microbes and metabolites and the potential roles of intestinal microbes were also explored in this study, in order to further reveal the interaction of the intestinal tract and the urinary system.…”

Section: Introductionmentioning

confidence: 99%

“…plantarum has been proved to regulate intestinal microbiota, but its effect to the treatment of kidney stones on the metabolites and the possible link between bacteria and metabolites are completely unclear. At present, the major metabolites studied are short‐chain fatty acids (SCFAs) and arginine 8,41,42 …”

Section: Introductionmentioning

confidence: 99%

“…38 In addition, recent studies showed that not only recombinant L. plantarum strains 39,40 but also L. plantarum without genetic modification can slow down the inflammation levels and reduce the content of urinary oxalic acid and the formation of kidney stones. 8,41 Even L. plantarum has been proved to regulate intestinal microbiota, but its effect to the treatment of kidney stones on the metabolites and the possible link between bacteria and metabolites are completely unclear. At present, the major metabolites studied are short-chain fatty acids (SCFAs) and arginine.…”

Section: Introductionmentioning

confidence: 99%

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Lactiplantibacillus plantarum J‐15 reduced calcium oxalate kidney stones by regulating intestinal microbiota, metabolism, and inflammation in rats

Tian

Liu

et al. 2022

The FASEB Journal

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The prevention role of Lactiplantibacillus plantarum against the formation of kidney stones has been increasingly recognized; its mechanism, however, has mainly been focused on inhibiting the inflammation in the colon in the gastrointestinal (GI) system, and the intestinal metabolites from microflora have not been revealed fully with regarding to the stone formation. In this study, we investigated the effect of L. plantarum J‐15 on kidney stone formation in renal calcium oxalate (CaOx) rats induced by ethylene glycol and monitored the changes of intestinal microflora and their metabolites detected by 16S rRNA sequencing and widely targeted analysis, followed by the evaluation of the intestinal barrier function and inflammation levels in the colon, blood and kidney. The results showed that L. plantarum J‐15 effectively reduced renal crystallization and urinary oxalic acid. Ten microbial genera, including anti‐inflammatory and SCFAs‐related Faecalibaculum, were enriched in the J‐15 treatment group. There are 136 metabolites from 11 categories significantly different in the J‐15 supplementation group compared with CaOx model rats, most of which were enriched in the amino acid metabolic and secondary bile acid pathways. The expression of intestinal tight junction protein Occludin and the concentration of pro‐inflammatory cytokines and prostaglandin were decreased in the intestine, which further reduced the translocated lipopolysaccharide and inflammation levels in the blood upon J‐15 treatment. Thus, the inflammation and injury in the kidney might be alleviated by downregulating TLR4/NF‐κB/COX‐2 signaling pathway. It suggested that L. plantarum J‐15 might reduce kidney stone formation by restoring intestinal microflora and metabolic disorder, protecting intestinal barrier function, and alleviating inflammation. This finding provides new insights into the therapies for renal stones.

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