Kidney Stone Prevention

Peerapen, Paleerath; Thongboonkerd, Visith

doi:10.1016/j.advnut.2023.03.002

Cited by 45 publications

(22 citation statements)

References 179 publications

(271 reference statements)

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“…On an individual level, kidney stone prevention practices will be more important than ever. The easiest and most effective strategy for prevention is oral rehydration [51]. Other prevention strategies may include weight loss, physical activity, and dietary changes [51].…”

Section: Future Directionsmentioning

confidence: 99%

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Climate change and kidney stones

Maline,

Goldfarb

2023

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review Kidney stones affect an increasing proportion of the population. We suggest that these trends are in part influenced by exposure to higher temperatures as a result of climate change and urbanization. The changing epidemiology of kidney stones is a topic worthy of discussion due to the economic and healthcare burden the condition poses as well as the quality-of-life disruption faced by individuals with kidney stones. Recent findings The relationship between heat and kidney stones is well supported. Exposure to high temperatures has been shown to increase risk for stone development within a short time frame. Effects are modified by factors such as sex, comorbid conditions, and population vulnerability and adaptability. Urban heat islands (UHIs) likely exaggerate the effect of increasing global surface temperature. The concentration of UHIs often coincides with historic redlining practices in the United States, potentially contributing to observed disparities in kidney health among minoritized populations. As global surface temperature increases and urbanization trends continue, a greater proportion of the world's population is exposed to significant temperature extremes each year, leading to the expectation that kidney stone prevalence will continue to increase. Summary This work describes the effect of increasing global surface temperature as a result of climate change on kidney stone disease and kidney health. These effects may result in further perpetuation of significant kidney stone related social disparities. We suggest strategies to mitigate the effects of heat exposure on stone formation.

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Section: Future Directionsmentioning

confidence: 99%

“…The easiest and most effective strategy for prevention is oral rehydration [51]. Other prevention strategies may include weight loss, physical activity, and dietary changes [51]. Mindful prevention will likely be most important during hotter, summer months, in anticipation of extreme heat events [52].…”

Section: Future Directionsmentioning

confidence: 99%

Climate change and kidney stones

Maline,

Goldfarb

2023

Current Opinion in Nephrology &Amp; Hypertension

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“…In the United States alone, the total expenditure for kidney stone treatment was approximately $2.1 billion in 2000, which has since risen to an estimated $3.79 billion. This expenditure is projected to reach another $1.24 billion annually by 2030, 11 further exacerbating the burden on the global healthcare system 12 …”

Section: Introductionmentioning

confidence: 99%

“…This expenditure is projected to reach another $1.24 billion annually by 2030, 11 further exacerbating the burden on the global healthcare system. 12 Currently, advancements in medical technology have provided significant benefits to patients, and surgical removal is the most commonly used and effective therapies treatment for kidney stones.…”

Section: Introductionmentioning

confidence: 99%

Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen

Dong,

Zhou,

et al. 2024

J Cellular Molecular Medi

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Kidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney stone formation is a complex, multi‐step and long‐term process involving the transformation of stone‐forming salts from free ions into asymptomatic or symptomatic stones influenced by physical, chemical and biological factors. Among the various types of kidney stones observed in clinical practice, calcareous nephrolithiasis is currently the most common and exhibits the most intricate formation mechanism. Extensive research suggests that calcareous nephrolithiasis primarily originates from interstitial subepithelial calcified plaques and/or calcified blockages in the openings of collecting ducts. These calcified plaques and blockages eventually come into contact with urine in the renal pelvis, serving as a nidus for crystal formation and subsequent stone growth. Both pathways of stone formation share similar mechanisms, such as the drive of abnormal urine composition, involvement of oxidative stress and inflammation, and an imbalance of stone inhibitors and promoters. However, they also possess unique characteristics. Hence, this review aims to provide detailed description and present recent discoveries regarding the formation processes of calcareous nephrolithiasis from two distinct birthplaces: renal interstitium and tubule lumen.

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“…Kidney stone is a globally prevalent disease, and its incidence and recurrence rates are increasing year by year. , The incidence and prevalence of kidney stones was up to 14.8% and a recurrence rate of up to 50% within the first 5 years of the initial stone episode . Oxalate is a common metabolic end product and a key component of most clinically detected calcium oxalate (CaOx) kidney stones. , …”

Section: Introductionmentioning

confidence: 99%

Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition

Deng,

Li,

Huang

et al. 2024

J. Agric. Food Chem.

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Oxidative damage to the kidneys is a primary factor in the occurrence of kidney stones. This study explores the inhibitory effect of Porphyra yezoensis polysaccharides (PYP) on oxalate-induced renal injury by detecting levels of oxidative damage, expression of adhesion molecules, and damage to intracellular organelles and revealed the molecular mechanism by molecular biology methods. Additionally, we validated the role of PYP in vivo using a crystallization model of hyperoxalate-induced rats. PYP effectively scavenged the overproduction of reactive oxygen species (ROS) in HK-2 cells, inhibited the adhesion of calcium oxalate (CaOx) crystals on the cell surface, unblocked the cell cycle, restored the depolarization of the mitochondrial membrane potential, and inhibited cell death. PYP upregulated the expression of antioxidant proteins, including Nrf2, HO-1, SOD, and CAT, while decreasing the expression of Keap-1, thereby activating the Keap1/Nrf2 signaling pathway. PYP inhibited CaOx deposition in renal tubules in the rat crystallization model, significantly reduced high oxalate-induced renal injury, decreased the levels of the cell surface adhesion proteins, improved renal function in rats, and ultimately inhibited the formation of kidney stones. Therefore, PYP, which has crystallization inhibition and antioxidant properties, may be a therapeutic option for the treatment of kidney stones.

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Kidney Stone Prevention

Cited by 45 publications

References 179 publications

Climate change and kidney stones

Climate change and kidney stones

Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen

Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition

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