Probiotic Debaryomyces hansenii CBS 8339 yeast enhanced immune responses in mice

Angulo, Miriam; Ramos, Abel; Reyes‐Becerril, Martha; Guerra, Kevyn; Monreal‐Escalante, Elizabeth; Angulo, Carlos

doi:10.1007/s13205-022-03442-6

Cited by 6 publications

(5 citation statements)

References 61 publications

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“…Some of its strains have been studied for potential use as probiotics and may be beneficial ( 59 ). Probiotic D. hansenii CBS 8339 yeast enhanced immune responses in mice by upregulating gene expression of proinflammatory cytokines such as INF-γ, IL6, and IL1β ( 60 ). In addition, two novel exopolysaccharides produced by D. hansenii DH-1 significantly inhibited the proliferation of Hela, HepG2, and PC-9 cancer cells, thus exhibiting the potential to be utilized as natural antioxidants and candidates for cancer treatment ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

Szóstak,

Handschuh,

Samelak-Czajka

et al. 2024

Cancer Immunology Research

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Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study we found that melanoma patients exhibited a distinct gut mycobiota structure compared to healthy participants. Candida albicans, Candida dubliniensis, and Neurospora crassa were more abundant in samples from patients with melanoma, while Saccharomyces cerevisiae and Debaryomyces hansenii were less abundant. During anti-PD-1 treatment, the relative amount of Malassezia restricta and C. albicans increased. A higher level of Saccharomyces paradoxus was associated with a positive response to anti-PD-1 treatment, while a higher level of Tetrapisispora blattae was associated with a lack of clinical benefits. High levels of M. restricta and C. albicans, elevated serum LDH, and overweight were linked to increased risk of melanoma progression and poorer response to anti-PD-1 treatment. Thus, this study has revealed melanoma-associated mycobiome dysbiosis, characterized by altered fungal composition and fungi species associated with a higher risk of melanoma progression, identifying a role for the gut mycobiome in melanoma progression.

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Section: Discussionmentioning

confidence: 99%

Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

Szóstak,

Handschuh,

Samelak-Czajka

et al. 2024

Cancer Immunology Research

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“…Nonvirulence without acute oral toxicity [82] Intestine of rainbow trout Mice Improvement in the immune innate response through enhanced phagocytic and respiratory burst activities, production of nitric oxide, IgA, and IgG; and upregulated gene expression of pro-inflammatory cytokines [86] Intestine of rainbow trout Goat Tolerance to acid pH Adhesion to goat intestine Antioxidant activity Improvement in the immune innate response through enhanced respiratory burst activity and production of nitric oxide Stimulation of the expression of immune-related gene signalling pathways [87] Lemon fruit Gilthead seabream…”

Section: Human Dendritic Cells Micementioning

confidence: 99%

Perspectives on the Probiotic Potential of Indigenous Moulds and Yeasts in Dry-Fermented Sausages

Álvarez,

Andrade,

Cebrián

et al. 2023

Microorganisms

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The role of indigenous fungi in the appropriate development of sensory properties and the safety of dry-fermented sausages has been widely established. Nonetheless, their applications as probiotic agents have not been elucidated in such products yet, despite their promising functional features. Thus, it should be interesting to evaluate the probiotic potential of native Debaryomyces hansenii isolates from dry-fermented sausages and their application in the meat industry, because it is the most frequently isolated yeast species from these foodstuffs and its probiotic effects for animals as well as its possible probiotic activity for human beings have been demonstrated. Within the functional ability of foodborne yeasts, anti-inflammatory, antioxidant, antimicrobial, antigenotoxic, and immunomodulatory properties have been reported. Similarly, the use of dry-fermented sausages as vehicles for probiotic moulds remains a challenge because the survival and development of moulds in the gastrointestinal tract are still unknown. Nevertheless, some moulds have been isolated from faeces possibly from their spores as a form of resistance. Additionally, their beneficial effects on animals and humans, such as the decrease in lipid content and the anti-inflammatory activity, have been reported, although they seem to be more related to their postbiotic capacity due to the generated bioactive compounds with profunctional attributes than to their role as probiotics. Therefore, further studies providing knowledge useful for generating dry-fermented sausages with improved functionality are fully necessary.

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“…Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain up to 50 billion CFU or more. However, higher CFU counts do not necessarily improve the product's health effects (Angulo et al 2023).…”

Section: Dietary Supplementsmentioning

confidence: 99%

“…In addition to total microorganism weight, manufacturers may now voluntarily list the CFUs in a product on the Supplement Facts label. Users should look for products labeled with the number of CFU at the end of the product's shelf life, not at the time of manufacture, as probiotics can die during their shelf life and must be consumed alive to have health (Angulo et al 2023).…”

Section: Dietary Supplementsmentioning

confidence: 99%

Probiotics in Human Nutrition, Health Improvement, Infection Prevention, and Disease Management - A Review

Kumari¹,

Bhattacharjee²,

Sadhu³

et al. 2023

Int. J. Res. Publ. Rev.

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Probiotics are Nonpathogenic microorganisms that are beneficial to one's nutritional health and are usually found in certain foods or supplements. They are typically bacteria, such as Lactobacillus, Bifidobacterium, Streptococcus, Leuconostocmesenteroides, Pediococcus, Propionibacterium, Bacillus, and Enterococcus faecium but can also be Yeast and molds. Probiotics help to maintain a healthy balance of gut microflora, which is important for digestion and overall health. They can also help with conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), allergies, ulcerative colitis, Crohn's disease, and even mental health issues. Probiotics may also play a role in preventing and treating other conditions such as urinary tract infections (UTIs), vaginal yeast infections, skin conditions like eczema, and even the common cold. Probiotics are involved in things like food digestion, the production of beneficial substances to eliminate harmful microbes, completing the roles of the digestive enzymes that were either not produced or had defects in their genes, maintaining the pH of the digestive system, and other things. Probiotics will improve the performance of our digestive system's biological fermenters (Ghoshal et al. 2022;Song et al 2023;Su et al. 2022). Prebiotics like FOS, GOS, XOS, inulin, and fructans are the most popular fibers that, when combined with probiotics, are known as synbiotics and can increase the viability of the probiotics. Numerous authors have discussed the development of probiotics, their history, and their various uses for them. In this review, we will primarily concentrate on three issues: health improvement, infection prevention, and disease management, all of which can be prevented by using various probiotics either directly or in foods.

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Probiotic Debaryomyces hansenii CBS 8339 yeast enhanced immune responses in mice

Cited by 6 publications

References 61 publications

Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

Perspectives on the Probiotic Potential of Indigenous Moulds and Yeasts in Dry-Fermented Sausages

Probiotics in Human Nutrition, Health Improvement, Infection Prevention, and Disease Management - A Review

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