Probiotic Dahi containing <i>Lactobacillus acidophilus</i> and <i>Bifidobacterium bifidum</i> modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice

Shandilya, Umesh K.; Sharma, Ankita; Kapila, Rajeev; Kansal, Vinod K.

doi:10.1002/jsfa.7497

Cited by 37 publications

(19 citation statements)

References 54 publications

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“…The probiotics with the ability to protect against food allergy are mostly Lactobacillus and Bifidobacterium . [ 17–25 ] Lactobacillus case i Zhang (LcZ) is a probiotic strain isolated from traditionally homemade koumiss in Inner Mongolia of China that has been intensively studied and shows various beneficial health effects such as anti‐inflammation, anti‐oxidation effects, stimulating lipid metabolism, and ameliorating intestinal microflora. [ 26–31 ] However, the application of the versatile probiotic in alleviating food allergy is limited, and the potential efficiency and underlying mechanisms are unclear.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Xie

Wang

et al. 2020

Molecular Nutrition Food Res

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Scope: Shellfish allergy is an important cause of food allergy, and tropomyosin (TM) is the major allergen within shellfish. Probiotics are safe bacteria that benefit host health and nutrition and is proposed as a novel approach for treating immunological diseases, including food allergies. Methods and results: The probiotic strain Lactobacillus casei Zhang (LcZ) isolated from koumiss is investigated for its capacity to modulate food allergyinduced by TM in BALB/c mice. Oral administration of LcZ attenuated allergy symptoms and intestinal epithelial damage. Furthermore, flow cytometry, real-time quantitative PCR, and ELISA demonstrated that LcZ administration altered the development and function of dendritic cells (DCs), T cells, and B cells, finally resulting in the change of TM-specific antibody isotypes into a tolerogenic pattern. Moreover, an in vitro spleen cell culture model reveals that LcZ directly modulates regulatory tolerogenic DC and T cell development, dependent on the activation of the nuclear factor kappa B (NF-B) signaling pathway. Conclusion: This work indicates the ability of LcZ to alleviate TM-induced food allergy and demonstrates the involvement of the tolerogenic immune cells and NF-B signaling pathway, indicating LcZ to be a potential immunomodulator and immunotherapy assistor.

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Section: Introductionmentioning

confidence: 99%

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Xie

Wang

et al. 2020

Molecular Nutrition Food Res

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“…Multiple sclerosis is an autoimmune disease of the CNS characterized by demyelination, inflammatory lesions, axonal damage, activation of IFN-γ-producing Th1 cells and IL-17-producing Th17 cells, inappropriate activation of innate immune cells (macrophages, dendritic cells, neutrophils, and microglia), and aberrant production of cytokines and chemokines ( Ryu et al, 2013 ; Cheng and Chen, 2014 ; Serada et al, 2016 ). Patients with MS experience abnormalities with respect to sensation, mobility, balance, sphincter function, vision, and cognition ( Brownlee et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

et al. 2018

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We recently reported that Lactobacillus helveticus SBT2171 (LH2171) inhibited the proliferation and inflammatory cytokine production of primary immune cells in vitro, and alleviated collagen-induced arthritis (CIA) in mice, a model of human rheumatoid arthritis (RA). In this study, we newly investigated whether LH2171 could relieve the severity of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), which is an autoimmune disease, but develop the symptoms by different mechanisms from RA. In MS and EAE, main cause of the disease is the abnormality in CD4+ T cell immunity, whereas in RA and CIA, is that in antibody-mediated immunity. The intraperitoneal administration of LH2171 significantly decreased the incidence and clinical score of EAE in mice. LH2171 also reduced the numbers of pathogenic immune cells, especially Th17 cells, in the spinal cord at the peak stage of disease severity. Interestingly, before the onset of EAE, LH2171 administration remarkably decreased the ratio of Th17 cells to CD4+ T cells in the inguinal lymph nodes (LNs), where pathogenic immune cells are activated to infiltrate the central nervous system, including the spinal cord. Furthermore, the expression of interleukin (IL)-6, an inflammatory cytokine essential for Th17 differentiation, decreased in the LNs of LH2171-administered mice. Moreover, LH2171 significantly inhibited IL-6 production in vitro from both DC2.4 and RAW264.7 cells, model cell lines of antigen-presenting cells. These findings suggest that LH2171 might down-regulate IL-6 production and the subsequent Th17 differentiation and spinal cord infiltration, consequently alleviating EAE symptoms.

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“…Probiotic candidates have been accessed from very diverse habitats including faeces of breastfed human infants [65,69,80,85,95], faeces of healthy adults [9,15,65,70], faeces of elderly [81], faeces of children [25,96], breast milk [42], human saliva [52], vaginal isolates of healthy women [66,75], various fermented foods or beverages including raw or fermented milk [23,35,44], kefir [97], cheese [51,56,98], whey [99], yogurt [16,41], dahi [100,101], other dairy products [25,36,61], sourdough [102], sausages [17], fermented meat [24], kimchi [10,62], maize [25,59], fermented olives [103], Yerba mate [79], ragi [64], soy sauce [86], soil [104], as well as animal origin including rat faeces [71], geese [68], c...…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Effect of Probiotics against Common Pathogens

Fijan¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The antimicrobial or antagonistic activity of probiotics is an important property that includes the production of antimicrobial compounds, competitive exclusion of pathogens, enhancement of the intestinal barrier function and others. There are many methods to ascertain probiotic properties, including various in vitro and in vivo methods. The in vivo methods include various modifications of the spot-on lawn assay, agar well diffusion assay "WD" , co-culturing methods, usage of cell lines and others. In many cases in vitro antagonist activity is observed, but in real settings it is not observed. The in vivo methods mainly used are animal models however, their use is being restricted according to the European legislation OJ L . The justification of animal models is also questionable as the results of studies on animals do not predict the same results for humans. The use of replacement alternative methods, for example incorporating human cells and tissues, avoids such confounding variables. Most important studies are doubleblinded randomized clinical trials however, these studies are difficult to perform as it is not easy to achieve uniform conditions. There is a clear need for more elaborate assays that would better represent the complex interactions between the probiotics and the final host. This complex situation is a challenge for scientists.

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Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice

Cited by 37 publications

References 54 publications

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

Antimicrobial Effect of Probiotics against Common Pathogens

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