Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice

Liu, Qi; Liu, Yunhuan; Li, Fengyuan; Gu, Zelin; Liu, Min; Shao, Tuo; Zhang, Lihua; Zhou, Guangyao; Pan, Chengwei; He, Liqing; Cai, Jun; Zhang, Xiang; Barve, Shirish; McClain, Craig J.; Chen, Yiping

doi:10.1016/j.jnutbio.2019.108256

Cited by 47 publications

(45 citation statements)

References 45 publications

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“…LGG also reduced liver weight and mesenteric and subcutaneous adipose tissues. Liu et al found that the probiotic culture supernatants of LGG reduced steatosis and inflammation with increased butyrate production in a mouse NAFLD model established by high-fat/high-fructose diet and intermittent hypoxia exposure [ 81 ].…”

Section: Modulation Of Gut Microbiota and Its Metabolitesmentioning

confidence: 99%

Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications

Chen¹,

Vitetta

2020

IJMS

179

137

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Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and supplementation with commensal bacterial metabolites can be of therapeutic benefit against the disease. In this review, we summarize the roles of various bacterial metabolites in the pathogenesis of NAFLD and their therapeutic implications. The gut microbiota dysregulation is a feature of NAFLD, and the signatures of gut microbiota are associated with the severity of the disease through altered bacterial metabolites. Disturbance of bile acid metabolism leads to underactivation of bile acid receptors FXR and TGR5, causal for decreased energy expenditure, increased lipogenesis, increased bile acid synthesis and increased macrophage activity. Decreased production of butyrate results in increased intestinal inflammation, increased gut permeability, endotoxemia and systemic inflammation. Dysregulation of amino acids and choline also contributes to lipid accumulation and to a chronic inflammatory status. In some NAFLD patients, overproduction of ethanol produced by bacteria is responsible for hepatic inflammation. Many approaches including probiotics, prebiotics, synbiotics, faecal microbiome transplantation and a fasting-mimicking diet have been applied to restore the gut microbiota for the improvement of NAFLD.

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Section: Modulation Of Gut Microbiota and Its Metabolitesmentioning

confidence: 99%

Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications

Chen¹,

Vitetta

2020

IJMS

179

137

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“…2007 [13] Animal study Expression Of AMPA And Fiaf Weight gain from foods containing fat and carbohydrate normalizing mRNA expression levels in obese mice with high fat and high fructose diet (HFFD) [19]. Also, fibroblast growth factor 21 (FGF21) manages the regulation of lipid metabolism and the profitable impact of probiotics (Lactobacillus rhamnosus GG) have been shown to alleviate the metabolic disorder and obesity in both human and mice [20].…”

Section: Role Of Probiotics In Current Treatmentsmentioning

confidence: 99%

A brief overview on the use of probiotics to treat overweight and obese patients

Daniali

Nikfar

Abdollahi

2020

Expert Review of Endocrinology & Metabolism

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“…Liu et al . [ 145 ] showed that probiotic culture supernatant improved metabolic function by activating the FGF21/adiponectin pathway in a preclinical model. They showed that Lactobacillus rhamnosus culture supernatants (LGGs) reduced NASH generated by high fat/high fructose diet plus intermittent hypoxia exposure (HFDIH).…”

Section: Treatment Strategy For Nash Targeting Gut Microbiomementioning

confidence: 99%

“…The authors showed that treatment with LGGs increased hepatic FGF21 mRNA expression and circulating FGF21 protein levels, as well as increased hepatic PPARα expression and fecal butyrate concentration. Further pre-clinical and clinical studies of probiotics are needed to determine their potential efficacy in NAFLD [ 145 ] .…”

Section: Treatment Strategy For Nash Targeting Gut Microbiomementioning

confidence: 99%