Probiotic Characterization of <i>Lactobacillus brevis</i> MJM60390 and <i>In Vivo</i> Assessment of Its Antihyperuricemic Activity

Lee, Youjin; Kim, Neagawooridwimeu; Werlinger, Pia; Suh, Dong-A; Lee, Hanki; Cho, Joo-Hyung; Cheng, Jinhua

doi:10.1089/jmf.2021.k.0171

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…In addition, about 14% of LAB isolates were ascribed to Weissella species, a genus constituting bacteria frequently isolated from food that are emerging for their promising health-promoting activities ( 37 ), such as the demonstrated properties in the oral cavity for the treatment of halitosis ( 38 ). We also isolated several other strains belonging to LAB species with well-recognized health-promoting (probiotic) capabilities, including the ability to survive gastrointestinal transit, such as Lactiplantibacillus plantarum ( 39 ), Lactococcus lactis ( 40 ), Latilactobacillus sakei ( 41 ), and Levilactobacillus brevis ( 42 ). Notably, the experiment of simulated orogastrointestinal digestion revealed the distinctly enhanced ability of rocket-associated LAB to survive gastrointestinal transit compared to the other bacterial members of the microbiota.…”

Section: Discussionmentioning

confidence: 99%

Ready-To-Eat Rocket Salads as Potential Reservoir of Bacteria for the Human Microbiome

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Ready-To-Eat Rocket Salads as Potential Reservoir of Bacteria for the Human Microbiome

et al. 2023

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“…Therefore, these results suggested that L. brevis MJM60390 could be a probiotic candidate to prevent HUA . Meanwhile, some studies found that Lactobacillus gasseri PA-3 attenuated the excessive absorption of dietary purines in humans, protecting these individuals against HUA …”

Section: Natural Active Substances With a Ua-reducing Effectmentioning

confidence: 96%

Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity

Zhang

Cui

Hou

et al. 2022

J. Agric. Food Chem.

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Hyperuricemia is a metabolic disease caused by the accumulation of uric acid in the body. Allopurinol, benzbromarone, and febuxostat, which are available in the market, have reduced the circulating urate levels; however, they exhibit serious side effects. Therefore, it is reasonable to develop a new active antihyperuricemia drug with few side effects. With the deepening of research, numerous kinds of literature have shown that natural active substances are effective in the treatment of hyperuricemia with a variety of sources and few side effects, which have become the focus of research in recent years. This review focuses on natural active substances with uric-acid-reducing activity and discusses their pharmacological effects. More specifically, the bioactive compounds of natural active substances are divided into five categories: natural extracts, monomer compounds extracted from plants, natural protease hydrolysates, peptides, and probiotic bacteria. In addition, the mechanisms by which these bioactive compounds exhibit hypouricemic effects can be divided into four classes: inhibition of key enzyme activities, promotion of uric acid excretion and inhibition of reabsorption in the kidney, promotion of decomposing uric acid precursors, and promotion of decomposing uric acid. Overall, this current and comprehensive review examines the role of natural active substances in the treatment of hyperuricemia.

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“…116 In an animal study, UA levels in serum were significantly reduced to normal levels after oral administration of Lactobacillus brevis MJM60390, which targeted the SCFA butyrate-producing Rikenellaceae family in the intestinal microbiome, increased its relative abundance, and achieved the effect of preventing and treating gout. 117 Drugs developed for the inflammatory factors produced in gout, such as procyanidin B2 (PCB2), can target IL-1β and cathepsin B in macrophages to alleviate the inflammatory response of gout. 118 In recent years, emerging microbial remediation has been widely accepted by the public as a cost-effective treatment method due to its minimal damage to sites in the body.…”

Section: Targ E Ting the Inte S Tinal MI Crob I Ome To Pre Vent And T...mentioning

confidence: 99%

Influence of intestinal microecology in the development of gout or hyperuricemia and the potential therapeutic targets

Dang,

Zhang,

Gao

et al. 2023

Int J of Rheum Dis

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Gout and hyperuricemia are common metabolic diseases. Patients with purine metabolism disorder and/or decreased uric acid excretion showed increased uric acid levels in the blood. The increase of uric acid in the blood leads to the deposition of urate crystals in tissues, joints, and kidneys, and causes gout. Recent studies have revealed that imbalance of the intestinal microecology is closely related to the occurrence and development of hyperuricemia and gout. Disorder of the intestinal flora often occurs in patients with gout, and high purine and high fructose may induce the disorder of intestinal flora. Short‐chain fatty acids and endotoxins produced by intestinal bacteria are closely related to the inflammatory response of gout. This article summarizes the characteristics of intestinal microecology in patients or animal models with hyperuricemia or gout, and explores the relationship between intestinal microecology and gout or hyperuricemia from the aspect of the intestinal barrier, intestinal microorganisms, intestinal metabolites, and intestinal immune system. We also review the current status of hyperuricemia treatment by targeting intestinal microecology.

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Probiotic Characterization of Lactobacillus brevis MJM60390 and In Vivo Assessment of Its Antihyperuricemic Activity

Cited by 15 publications

References 41 publications

Ready-To-Eat Rocket Salads as Potential Reservoir of Bacteria for the Human Microbiome

Ready-To-Eat Rocket Salads as Potential Reservoir of Bacteria for the Human Microbiome

Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity

Influence of intestinal microecology in the development of gout or hyperuricemia and the potential therapeutic targets

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