Probiotic Bacteria in the Prevention and the Treatment of Inflammatory Bowel Disease

Fedorak, Richard N.; Demeria, Denny

doi:10.1016/j.gtc.2012.08.003

Cited by 22 publications

(9 citation statements)

References 87 publications

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“…analyzed randomized clinical trials and found that selected probiotics were efficacious in inducing and maintaining remission in UC [8]. Another review reached nearly the same conclusions on the efficacy of probiotics in UC [9].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, probiotic mixture VSL#3 given to adult patients with mild-to-moderate UC caused a 50% decrease in the UC disease activity index at 6 weeks in a significantly higher number of the treated patients than in the placebo group [7]. A more recent review analyzed randomized clinical trials and found that selected probiotics were efficacious in inducing and maintaining remission in UC [8]. Another review reached nearly the same conclusions on the efficacy of probiotics in UC [9].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study

Zurek¹,

Wcisło²,

Mach³

et al. 2017

J Prob Health

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Background: Ulcerative colitis (UC) is one of the chronic, relapsing, inflammatory disorders of the gut and is characterized by inflammation limited in most cases to the colon. Since gut microbiota play a critical role in the development and perpetuation of intestinal inflammation, the addition of probiotics to this complex system may exert a positive influence on gut inflammatory reactions. Methods:A single center, open-label, intention-to-treat study involving patients with moderate-to-severe UC was performed to check whether a probiotic mixture containing Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium longum given together with a standard treatment could decrease clinical and histopathology indexes for UC evaluation. Results:The mixture given once a day for at least 2 months together with mesalazine and ciprofloxacin to patients in the acute phase of UC significantly reduced their Mayo Clinic Index values. Moreover, numbers of Lactobacilli isolated from patients feces were significantly increased, while those of Gram-negative rods decreased. The mixture given together with mesalazine to patients with UC in remission also caused a decrease of their clinical scores, but a more prominent and significant decrease of the histopathological index values in biopsy samples was observed. Conclusions:Supplementation of standard therapy with the probiotic mixture used in this study was efficacious in inducing and maintaining remission in UC, and this effect was related to modulation of dysbiosis in the gut microbiota. analyzed randomized clinical trials and found that selected probiotics were efficacious in inducing and maintaining remission in UC [8]. Another review reached nearly the same conclusions on the efficacy of probiotics in UC [9]. Influence of Lactobacillus and Bifidobacterium Combination on the Gut• The aim of this study was to investigate in a single center, openlabel, intention-to-treat study involving patients with moderateto-severe UC whether a probiotic mixture containing Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium longum given together with standard therapy could decrease clinical and histopathology indexes for UC. Materials and Methods PatientsAltogether, 51 patients (21 with UC in remission and 30 in the active phase of UC) of both sexes and between 18 and 72 years of age who were being treated in the Jagiellonian University Medical College Clinic of Gastroenterology in Cracow, Poland were enrolled. The study was conducted from 2008 to 2011 and was approved by the Jagiellonian University independent ethics committee (No KBET/5/B/2007). Written informed consent was obtained from all patients before enrollment.Inclusion criteria included an existing diagnosis of UC based on disease history, colonoscopy results, and histopathologic evaluation of biopsies from the colonic mucosa. The patients were not treated with antibiotics for three months before enrollment. Exclusion criteria were: diabetes, autoimmune diseases, severe systemic diseases, alcoho...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study

Zurek¹,

Wcisło²,

Mach³

et al. 2017

J Prob Health

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“…Some authors theorize that probiotics exert their protective effects against oxidative stress by restoring the gut microbiota (25). Acting in this way, antioxidant probiotic strains can be chosen and investigated as promising candidates for the prevention and control of several free radical-related disorders (26)(27)(28). Finally, L. acidophilus as a probiotic plays an important role in the alteration of oxidative injuries through TAP.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect ofLactobacillus acidophilusas a Probiotic at Different Time Intervals

Nazari¹,

Delborde²,

Karimitabar³

et al. 2016

Avicenna J Clin Microbiol Infect

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Background: Probiotics are survival microorganisms that, when administered in sufficient amounts, confer health benefits to the host and can be used in an antioxidative role. Objectives: The antioxidative effect of whole cells and intracellular cell-free extracts of the lactic acid bacteria Lactobacillus acidophilus (PTCC 1643) as a probiotic at three different time intervals was investigated. Materials and Methods: Antioxidant biomarkers, such as total antioxidant power (TAP), measured with the FRAP (ferric-reducing ability of plasma) method, were evaluated at 24, 48, and 72 hours. Results:The results showed that extracts and bacteria of L. acidophilus were able to significantly increase TAP after 24 and 72 hours. Conclusions:The results showed that the effect of L. acidophilus is time-dependent.

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“…Another common feature of both intestinal PRD and IBD is the associated dysregulation of gut microbiota (dysbiosis) [25, 26]. Dysbiosis is known to be present in IBD, both CD and UC, and contribute to the associated dysregulated immune response [25].…”

Section: Role Of Nutritional Therapy In the Management Of Intestinmentioning

confidence: 99%

“…Dysbiosis is known to be present in IBD, both CD and UC, and contribute to the associated dysregulated immune response [25]. IBD patients with active disease show altered microbial diversity [27] with an increase in pathogenic microbes such as Escherichia coli as compared to healthy control subjects [28].…”

Section: Role Of Nutritional Therapy In the Management Of Intestinmentioning

confidence: 99%

Nutrition in Pelvic Radiation Disease and Inflammatory Bowel Disease: Similarities and Differences

DeWitt

Hegazi

2014

BioMed Research International

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Due to the intestinal inflammation, tissue damage, and painful abdominal symptoms restricting dietary intake associated with both diseases, patients with intestinal pelvic radiation disease (PRD) or inflammatory bowel disease (IBD) are at increased risk to develop protein calorie malnutrition and micronutrient deficiencies. In the current paper, we review the nutritional management of both diseases, listing the similar approaches of nutritional management and the nutritional implications of intestinal dysfunction of both diseases. Malnutrition is prevalent in patients with either disease and nutritional risk screening and assessment of nutritional status are required for designing the proper nutritional intervention plan. This plan may include dietary management, oral nutritional supplementation, and enteral and/or parenteral nutrition. In addition to managing malnutrition, nutrients exert immune modulating effects during periods of intestinal inflammation and can play a role in mitigating the risks associated with the disease activity. Consistently, exclusive enteral feeding is recommended for inducing remission in pediatric patients with active Crohn's disease, with less clear guidelines on use in patients with ulcerative colitis. The field of immune modulating nutrition is an evolving science that takes into consideration the specific mechanism of action of nutrients, nutrient-nutrient interaction, and preexisting nutritional status of the patients.

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Probiotic Bacteria in the Prevention and the Treatment of Inflammatory Bowel Disease

Cited by 22 publications

References 87 publications

Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study

Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study

Antioxidant Effect ofLactobacillus acidophilusas a Probiotic at Different Time Intervals

Nutrition in Pelvic Radiation Disease and Inflammatory Bowel Disease: Similarities and Differences

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