Probiotic Application of Bacteriocin-Producing S. Epidermidis in A Cellulosic Pad to Treat Some Skin Infections

Hussein, Yasser; Luti, Khalid Jaber Kadhum

doi:10.24996/ijs.2020.61.8.10

Cited by 2 publications

(1 citation statement)

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“…Development of resistant fungi and therapy failures following longterm use of antifungal drugs have been increased in immunocompromised patients ]6]. Therefore, finding an alternative of some useful compounds, such as bacteriocin, for the better control and treatment of microbial infections has been suggested ]7, 8,9]. The fungicidal effect of plantaricins (Pln E/F and J/K) against C. albicans was investigated by Sharma and Srivastava [10[.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic Activity of Bacteriocin-producing Lactobacillus Against Candida spp

Mohsin

Ali

2021

eijs

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In order to screen antifungal activity of lactobacilli that produce bacteriocin against the yeast Candida, ninety-two food and clinical samples were collected. Also, several commercial brands of Lactobacillus probiotics and ready-made isolates of Lactobacillus were used. The isolated lactobacilli were subjected to microscopic, macroscopic, and biochemical tests. Moreover, molecular identification was performed for the best producer isolate. For Candida spp. isolation, seventy- two samples were collected from different clinical sources; in addition, nine of ready-made isolates were also used. All the isolated Candida spp. were subjected to microscopic and macroscopic examinations which were confirmed by VITEK® 2 YST card automated system. Detection of bacteriocin production from Lactobacillus was investigated by primary and secondary screening techniques and the results showed that the agar wells diffusion method was the best. The most efficient isolate to produce bacteriocin was L. plantarum WZD3, in which antifungal activity of bacteriocin was at the level of 80 and 40 AU/ml against the most sensitive Candida isolates; C. albicans CA and C. albicans CB, respectively. After partial purification of bacteriocin by n-butanol extraction method, bacteriocin activity was increased to 320 AU/ml against both yeast isolates. In conclusion, L. plantarum WZD3 or its bacteriocin could be a good candidate as antifungal agent to treat Candida infections and more studies are required to evaluate its acivity against other types of medical fungi.

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Section: Introductionmentioning

confidence: 99%

Antagonistic Activity of Bacteriocin-producing Lactobacillus Against Candida spp

Mohsin

Ali

2021

eijs

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Encapsulation of Commensal Skin Bacteria within Membrane‐in‐Gel Patches

Nouri

Demoustier‐Champagne

et al. 2022

Adv Materials Inter

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dermatitis, psoriasis, and acnes, considered to arise at least partly from an alteration of these bacterial communities. [2a,4] Staphylococcus epidermidis (S. epidermidis), a permanent member of the human skin microbiota, has been extensively studied because of its prevalence on skin sites and its numerous benefits to hosts. On the one hand, some strains of S. epidermidis have been shown to promote the production of antimicrobial peptides (AMPs) by keratinocytes, [5] and induce T-cell development, [6] resulting in the enhancement of the innate immune protection. The extent and duration of the immune response has also been reported to be controlled by S. epidermidis which diminishes excessive inflammation after injury. [7] On the other hand, diverse molecules, such as phenolsoluble modulins, [8] serine proteases, [9] and nucleobase analogs, [10] can be produced by specific strains of S. epidermidis, leading to the suppression of adjacent microorganism growth. S. epidermidis itself can also secrete AMPs, which have been shown to synergize with the innate immune response to protect the host against pathogens. [11] Therefore, instead of using antibiotics, which have the potential to cause bacterial resistance, bacteriotherapy has been advocated as a promising alternative to prevent skin colonization by pathogenic bacteria. [12] The introduction of S. epidermidis on patients' skin has been shown to significant reduce the colonization by S. aureus and group A Streptococcus. [8-9,11b,13] The short-chain fatty acids produced by S. epidermidis fermentation have been demonstrated to control the growth of Cutibacterium acnes, [11a,14] and of Propionibacterium acnes, [15] which are both important acne triggers.Human beings are colonized by a variety of S. epidermidis strains showing a diversity in pathogenicity. [16] For example, the non biofilm-forming strain ATCC 12228, which lacks the ica operon, [17] is a non-pathogenic commensal. However, some S. epidermidis strains are invasive and are major pathogens in nosocomial infections when they pass through the skin surface and enter the bloodstream via medical devices, for instance. For instance, 47% of coagulase-negative Staphylococci infections are due to S. epidermidis strains which often are methicillin-and multidrug-resistant. [18] Genomic analysis of both commensal and nosocomial strains demonstrate that they share approximately 80% of their genomes, with the 20%

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Probiotic Application of Bacteriocin-Producing S. Epidermidis in A Cellulosic Pad to Treat Some Skin Infections

Cited by 2 publications

References 35 publications

Antagonistic Activity of Bacteriocin-producing Lactobacillus Against Candida spp

Antagonistic Activity of Bacteriocin-producing Lactobacillus Against Candida spp

Encapsulation of Commensal Skin Bacteria within Membrane‐in‐Gel Patches

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