Probiotic and prebiotic use in patients with inflammatory bowel disease

Hedin, Charlotte; Mullard, Miriam; Sharratt, Elizabeth; Jansen, Clare; Sanderson, Jeremy; Shirlaw, Penelope; Howe, Leslie C.; Djemal, Serpil; Stagg, Andrew J.; Lindsay, James O.; Whelan, Kevin

doi:10.1002/ibd.21286

Cited by 57 publications

(46 citation statements)

References 69 publications

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“…Although the effects of new drugs on the relapse of UC were reported recently (24)(25)(26)(27)(28)(29)(30), this effect was not observed in the current study about mesalazin. It is highly recommended to use new generations of UC drugs and increase visits of high risk patients for relapse in the region under study.…”

Section: Discussioncontrasting

confidence: 66%

Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran

et al. 2016

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Section: Discussioncontrasting

confidence: 66%

Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran

et al. 2016

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“…Hedin et al, [35] reported a case-control study about the use of probiotics and prebiotics in patients with IBD. They described that a high percentage of IBD patients used probiotics to manage their health compared to controls (without IBD).…”

Section: Probiotics As Treatments For Inflamma-tory Bowel Diseasementioning

confidence: 99%

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

LeBlanc¹,

Carmen²,

Zurita-Turk³

et al. 2012

AIA

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Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates in the inflammatory processes and in the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.

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“…Many experimental and clinical use of probiotics for inflammatory bowel disease with promising results has been extensively reported (Alfaleh, Anabrees et al 2008;Hedin, Mullard et al 2010). The application for urinary tract infection is increasing.…”

Section: Probioticsmentioning

confidence: 99%

Urinary Tract Infection in Children

Dh²

2011

Clinical Management of Complicated Urinary Tract Infection

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Probiotic and prebiotic use in patients with inflammatory bowel disease

Cited by 57 publications

References 69 publications

Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran

Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

Urinary Tract Infection in Children

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