We present the Technicolor Dawn simulations, a suite of cosmological radiationhydrodynamic simulations of the first 1.2 billion years. By modeling a spatiallyinhomogeneous UVB on-the-fly with 24 frequencies and resolving dark matter halos down to 10 8 M ⊙ within 12h −1 Mpc volumes, our simulations unify observations of the intergalactic and circumgalactic media, galaxies, and reionization into a common framework. The only empirically-tuned parameter, the fraction f esc,gal (z) of ionizing photons that escape the interstellar medium, is adjusted to match observations of the Lyman-α forest and the cosmic microwave background. With this single calibration, our simulations reproduce the history of reionization; the stellar mass-star formation rate relation of galaxies; the number density and metallicity of damped Lyman-α absorbers (DLAs) at z ∼ 5; the abundance of weak metal absorbers; the ultraviolet background (UVB) amplitude; and the Lyman-α flux power spectrum at z = 5.4. The galaxy stellar mass and UV luminosity functions are underproduced by ≤ 2×, suggesting an overly vigorous feedback model. The mean transmission in the Lyman-α forest is underproduced at z < 6, indicating tension between measurements of the UVB amplitude and Lyman-α transmission. The observed Si IV column density distribution is reasonably well-reproduced (∼ 1σ low). By contrast, C IV remains significantly underproduced despite being boosted by an intense > 4 Ryd UVB. Solving this problem by increasing metal yields would overproduce both weak absorbers and DLA metallicities. Instead, the observed strength of high-ionization emission from high-redshift galaxies and absorption from their environments suggest that the ionizing flux from conventional stellar population models is too soft.