Probing the Interactions of the Anticancer Drug Doxorubicin with Polymeric Nanoparticles Using Fluorescence Spectroscopy

Henry-Toulmé, Nelly; Decout, Anne; Lalanne, J. R.; Némati, Fariba; Dubernet, Catherine; Dufourcq, Jean

doi:10.1006/jcis.1994.1031

Cited by 11 publications

(10 citation statements)

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“…Nevertheless, the constant adhesion measured above pH 6 (É3 k B T per particle) is Eq. [ 4 ] ) . The same limitations apply on the actual values extracted from the measurement, as already stated in Sec-more likely to be due to the actual dispersion forces acting between the particles.…”

Section: Layer-layer Interactionmentioning

confidence: 93%

“…The composition of the precipitate further with these issues through a study of forces acting is CeO 2 (HNO 3 ) 0.5 (H 2 O) 4 . Upon addition of water this prebetween adsorbed layers of ceria (this article) and between cipitate redisperses spontaneously into a colloidal sol.…”

Section: Introductionmentioning

confidence: 99%

“…been investigated. The investigation undoubtedly demonThe colloidal solutions obtained by dispersions of the prestrates that the colloidal stability of dispersions composed cipitate CeO 2 (HNO 3 ) 0.5 (H 2 O) 4 in water contain high conof nanometric particles is related to the absence of an adhesion at contact between particles. Furthermore, the range of centrations of nitric acid and low concentrations of other solution conditions for which the dispersion is stable can be ions, mainly Ce III cations or polycations.…”

Section: Introductionmentioning

confidence: 99%

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Adhesion between Oxide Nanoparticles: Influence of Surface Complexation

Spalla

Kékicheff

1997

Journal of Colloid and Interface Science

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Section: Layer-layer Interactionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adhesion between Oxide Nanoparticles: Influence of Surface Complexation

Spalla

Kékicheff

1997

Journal of Colloid and Interface Science

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“…[17,18]), polyalkylcyanoacrylates have produced very promising results as polymeric substrates in the preparation of injectable nanoparticle delivery systems. Interestingly, one of its most promising therapeutic applications is in antineoplastic therapy, because of their ability to reverse in vitro tumor-cell resistance to anticancer drugs [19][20][21]. These particles compare favorably to other biodegradable polymers such as alginate, poly(lactide) or poly(lactide-co-glycolide) [22].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles

Arias

Gallardo

Linares-Molinero

et al. 2006

Journal of Colloid and Interface Science

105

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“…Examples of anticancer agents investigated for nanoparticle formulation include doxorubicin [12][13][14][15][16][17][18][19][20][21][22][23][24] and 5-FU [25][26][27]. Nanoparticle formulation of paclitaxel has also been under intensive investigation in the recent years [28][29][30][31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Biodegradable Polymers for Clinical Administration of Paclitaxel

Feng

Li²,

Win³

et al. 2004

CMC

284

136

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Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades, which has been found effective against a wide spectrum of cancers including ovarian cancer, breast cancer, small and non small cell lung cancer, colon cancer, head and neck cancer, multiple myeloma, melanoma, and Kaposi's sarcoma. Like many other anticancer drugs, it has difficulties in clinical administration due to its poor solubility in water and most pharmaceutical reagents. In its current clinical application, an adjuvant called Cremophor EL has to be employed, which has been found to be responsible for many serious side effects. Nanoparticles of biodegradable polymers can provide an ideal solution to such an adjuvant problem and realize a controlled and targeted delivery of the drug with better efficacy and less side effects. With further development, such as particle size optimization and surface coating, nanoparticle formulation of paclitaxel can promote a new concept of chemotherapy to realize its full efficacy and to improve quality of life of the patients, which includes personalized chemotherapy, local chemotherapy, sustained chemotherapy, oral chemotherapy, chemotherapy across the blood-brain barrier, chemotherapy across the microcirculation barrier, etc. The present research proposes a novel formulation for fabrication of nanoparticles of poly(lactic-co-glycolic acid) (PLGA) by a modified solvent extraction/evaporation technique, in which natural emulsifiers, such as phospholipids, cholesterol and vitamin E TPGS are creatively applied to achieve high drug encapsulation efficiency, desired drug released kinetics, high cell uptake and high cytotoxicity. The nanoparticles composed of various recipes and manufactured under various conditions were characterized by laser light scattering (LLS) for size and size distribution, scanning electron microscopy (SEM) and atomic force microscopy (AFM) for morphological properties, X-ray photoelectron spectroscopy (XPS) and Fourier Transformation Infrared Spectroscopy (FTIR) for surface chemistry, zeta-potential for surface charge, and differential scanning calorimetry (DSC) for the thermogram properties. The drug encapsulation efficiency and the drug release kinetics under in vitro conditions were measured by high performance liquid chromatography (HPLC). It was found that these natural emulsifiers have great advantages for nanoparticle formulation of paclitaxel over the traditional macromolecular emulsifiers, such as polyvinyl alcohol (PVA). Nanoparticles of desired small size and narrow size distribution can be obtained. The drug encapsulation efficiency can be achieved as high as 100 %. The released kinetics can be made under control. The HT-29 cancer cell line experiment showed that after 24 hours of incubation, the cell mortality caused by the drug administered by such nanoparticle formulation could be more than 13 times higher than that caused by the free drug under similar conditions.

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Probing the Interactions of the Anticancer Drug Doxorubicin with Polymeric Nanoparticles Using Fluorescence Spectroscopy

Cited by 11 publications

References 0 publications

Adhesion between Oxide Nanoparticles: Influence of Surface Complexation

Adhesion between Oxide Nanoparticles: Influence of Surface Complexation

Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles

Nanoparticles of Biodegradable Polymers for Clinical Administration of Paclitaxel

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