Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles

Arias, José L.; Gallardo, V.; Linares-Molinero, Fernando; Delgado, A.V.

doi:10.1016/j.jcis.2006.03.005

Cited by 104 publications

(78 citation statements)

References 31 publications

(47 reference statements)

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“…Iron NPs possess good magnetic property and thus have been used as the magnetic cores for some drug delivery purposes [37][38][39]. Previously, Chen et al have reported the direct reduction of Fe 2 O 3 to metallic iron on the inner and external surface of CNTs [36,40].…”

Section: Synthesis and Characterization Of The Dual-targeted Drug Nanmentioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

134

125

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Section: Synthesis and Characterization Of The Dual-targeted Drug Nanmentioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

134

125

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“…On the opposite, differences between the surface electrical charge of PBCA and PCL NPs were relevant (Tables I and II): PCL NPs were less negative, this postulating a reduced interaction with the reticuloendothelial system and, therefore, a more appropriate in vivo fate (for drug delivery purposes) compared with the PBCA NPs (i.e., greater accumulation into the tumor site) (35). Finally, our research group has previously published information on the surface thermodynamics of both nanoformulations: they can be considered to be hydrophobic (15,36).…”

Section: Discussionmentioning

confidence: 98%

Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer

Ortíz

Cabeza

Arias

et al. 2015

AAPS J

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ABSTRACT. The clinical use of 5-fluorouracil, one of the drugs of choice in colon cancer therapy, is limited by a nonuniform oral absorption, a short plasma half-life, and by the development of drug resistances by malignant cells. We hypothesized that the formulation of biodegradable nanocarriers for the efficient delivery of this antitumor drug may improve its therapeutic effect against advanced or recurrent colon cancer. Hence, we have engineered two 5-fluorouracil-loaded nanoparticulate systems based on the biodegradable polymers poly(butylcyanoacrylate) and poly(ε-caprolactone). Drug incorporation to the nanosystems was accomplished by entrapment (encapsulation/dispersion) within the polymeric network during nanoparticle synthesis, i.e., by anionic polymerization of the monomer and interfacial polymer disposition, respectively. Main factors determining 5-fluorouracil incorporation within the polymeric nanomatrices were investigated. These nanocarriers were characterized by high drug entrapment efficiencies and sustained drug-release profiles. In vitro studies using human and murine colon cancer cell lines demonstrated that both types of nanocarriers significantly increased the antiproliferative effect of the encapsulated drug. In addition, both nanoformulations produced in vivo an intense tumor growth inhibition and increased the mice survival rate, being the greater tumor volume reduction obtained when using the poly(ε-caprolactone)-based formulation. These results suggest that these nanocarriers may improve the antitumor activity of 5-fluorouracil and could be used against advanced or recurrent colon cancer.

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“…Aquacoat ® appeared as spherical particles of similar size, with a mean diameter of 339 nm (standard deviation 61 nm). 22 Kollicoat ® at its natural pH appeared as very tiny spherical particles of similar size, with a mean diameter of approximately 80 nm. Aquateric ® consisted of two clearly different populations of particles, one with a mean diameter of 25-30 nm and one consisting of fewer but larger particles with a mean diameter of approximately 4 μm.…”

Section: Electron Microscopymentioning

confidence: 97%

Calorimetric, electrophoretic, and microscopic characterization of polymer–drug complexes

et al. 2008

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The preparation of polymer–drug complexes is one of the techniques used to obtain modified release formulations for use in different pharmaceutical forms. In this study, we prepared complexes with four commercially available latexes of different characteristics and two photoprotectors to determine the calorimetric, electrophoretic, and microphotographic characteristics of the complexes. The findings shed light on the interactions between the different polymers and drugs and on the differences between complexes as a result of differences in particle size. © 2008 Wiley Periodicals, Inc. Adv Polym Techn 27:47–55, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20119

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Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles

Cited by 104 publications

References 31 publications

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Poly(butylcyanoacrylate) and Poly(ε-caprolactone) Nanoparticles Loaded with 5-Fluorouracil Increase the Cytotoxic Effect of the Drug in Experimental Colon Cancer

Calorimetric, electrophoretic, and microscopic characterization of polymer–drug complexes

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