Probing ND7/23 neuronal cells before and after differentiation with SERS using Sharp-tipped Au nanopyramid arrays

Iarossi, Marzia; Hubarevich, Aliaksandr; Iachetta, Giuseppina; Dipalo, Michele; Huang, Jian‐An; Darvill, Daniel; Angelis, Francesco De

doi:10.1016/j.snb.2022.131724

Cited by 17 publications

(8 citation statements)

References 102 publications

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“…Preparation of PNAs and Transferring on a Holey Supporting Substrate: First, PS nanospheres were assembled at the water-air interface of a water bath using a previously developed interfacial self-assembly method to form hexagonally close-packed (hcp) arrays of nanoparticles. [71,72] Briefly, nanospheres were first spread to form hexagonal close-packed (hcp) grains on a hydrophilized silicon wafer at an angle before being transferred to a water bath. Negatively charged PS spheres with a diameter of 140 nm were acquired from microParticles GmbH.…”

Section: Methodsmentioning

confidence: 99%

High‐Density Plasmonic Nanopores for DNA Sensing at Ultra‐Low Concentrations by Plasmon‐Enhanced Raman Spectroscopy

Iarossi

Darvill

Hubarevich

et al. 2023

Adv Funct Materials

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Solid‐state nanopores are implemented in new and promising platforms that are capable of sensing fundamental biomolecular constituents at the single‐molecule level. However, several limitations and drawbacks remain. For example, the current strategies based on both electrical and optical sensing suffer from low analyte capture rates and challenging nanofabrication procedures. In addition, their limited discrimination power hinders their application in the detection of complex molecular constructs. In contrast, Raman spectroscopy has recently demonstrated the ability to discriminate both nucleotides and amino acids. Herein, a plasmonic nanoassembly is proposed supporting nanopores at high density, in the order of 100 pores per µm2. These findings demonstrate that the device has a high capture rate in the range of a few fm. The pore size is ≈10 nm in diameter and provides an amplification of the electromagnetic field exceeding 103 in intensity at 785 nm. Owing to these features, single‐molecule detection is achieved by means of surface‐enhanced Raman scattering from a solution containing 50 fm DNA molecules (≈4.4 kilobase pairs). Notably, the reported spectra show an average number of 2.5 Raman counts per nucleotide. From this perspective, this number is not far from what is necessary to discriminate the DNA sequence.

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Section: Methodsmentioning

confidence: 99%

High‐Density Plasmonic Nanopores for DNA Sensing at Ultra‐Low Concentrations by Plasmon‐Enhanced Raman Spectroscopy

Iarossi

Darvill

Hubarevich

et al. 2023

Adv Funct Materials

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“…SERS substrates consist of two essential components: (i) nanomaterials that induce plasmon resonance and (ii) a supporter. The common approach involves depositing nanoplasmonic materials onto solid supports like glass, silicon, or aluminum [ [7] , [8] , [9] , [10] , [11] ]. For instance, Chiang et al successfully utilized a sputtering method to grow Ag films on glass substrates, enabling the impressive detection of crystal violet with a limit of detection of 10 −11 M [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Flexible, high-performance and facile PVA/cellulose/Ag SERS chips for in-situ and rapid detection of thiram pesticide in apple juice

Pham,

Bui,

Mai

et al. 2023

Heliyon

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“…[ 4,6–11 ] Like plasmonics, magnetic domain wall reversal and spin‐wave damping in periodic nanostructures have immense potential in next‐generation spintronic‐based memory applications. [ 12–17 ] In brief, large‐area periodic nanocrystals find their utilities in surface engineering with functional magnetic, [ 18–20 ] plasmonic, [ 21–25 ] photonic, [ 26–28 ] and catalytic properties [ 29,30 ] opening a huge scope in various sensor, memory, waveguide, filters, thermal dissipator, and chemical applications. In this case, the geometry of the nanostructure plays a vital role in tuning these functional properties as resonance conditions from the dispersion relation dramatically alter with changing geometry.…”

Section: Introductionmentioning

confidence: 99%

Controlling Vertical Asymmetry of Nanocrystals Through Anisotropic Etching‐Assisted Nanosphere Lithography

Ganguly,

Zafar,

Howells

et al. 2023

Small Structures

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Nanosphere lithography, a low‐cost fabrication technique, depends on the self‐assembly of nanoscale features to create nanostructures in a hexagonally close‐packed structure. In this article, the fabrication of 3D nanostructures over a large surface‐area with anisotropy along the growth direction through the combination of chemical and physical plasma etching is reported. The anisotropy stems from etching the nanosphere mask and the substrate at different rates. Due to the dynamic masking effect, a systematic variation of etching time gives rise to intriguing nanostructures with sharp edges that have strong potential for plasmonic applications, with the possibility of manipulating electromagnetic radiation. The structures obtained include nanocylinders, truncated hexagon‐based pyramids, circular pads on a conical base, and nanocones from a single‐layer nanosphere mask. Simulations of the fabrication process offer further insight into the understanding of nanostructure formation. A good agreement between predicted results and experiments confirms the potential of our numerical design. In addition, the optical properties of the nanostructures are investigated by UV–vis and the experimental findings are consistent with simulations based on a finite‐difference time‐domain method. The nanostructures described in this study contribute to the emerging 3D plasmonics and 3D magnonics, with strong potential for a significant impact on biosensor applications.

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Probing ND7/23 neuronal cells before and after differentiation with SERS using Sharp-tipped Au nanopyramid arrays

Cited by 17 publications

References 102 publications

High‐Density Plasmonic Nanopores for DNA Sensing at Ultra‐Low Concentrations by Plasmon‐Enhanced Raman Spectroscopy

High‐Density Plasmonic Nanopores for DNA Sensing at Ultra‐Low Concentrations by Plasmon‐Enhanced Raman Spectroscopy

Flexible, high-performance and facile PVA/cellulose/Ag SERS chips for in-situ and rapid detection of thiram pesticide in apple juice

Controlling Vertical Asymmetry of Nanocrystals Through Anisotropic Etching‐Assisted Nanosphere Lithography

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