Probing interactions and hydration behaviour of drug sodium salicylate in aqueous solutions of D-xylose/L-arabinose: Volumetric, acoustic and viscometric approaches

Volumetric, Viscometric, and Refractive Index Studies of Drug Nicotinic Acid in Aqueous d-Xylose/l-Arabinose Solutions from 293.15 to 313.15 K: Insights into Solute–Solute and Solute–Solvent Interactions

“…When the hydroxyl groups of the two carbohydrates interact with the hydrophilic sites of nicotinic acid molecules, the hydrogen bond interactions in aqueous l -arabinose solution are stronger than those in aqueous d -xylose solution because of steric hindrance. , On the other hand, the enhancement of solute–solvent interactions due to the position of the hydroxyl group weakens the hydrophilic–hydrophilic interaction between the two nicotinic acid molecules, which results in the decrease in the S v values for aqueous l -arabinose solution . Similar trends for V ϕ 0 and Δ trs V ϕ 0 values were also observed by Nain et al for isoniazid, l -proline, betaine hydrochloride, and sodium salicylate in aqueous d -xylose / l -arabinose solutions.…”

“…According to Desnoyers’ cosphere overlap model, various types of interactions in the nicotinic acid + water + d -xylose/ l -arabinose ternary systems can be summarized as follows: hydrophobic–hydrophobic interactions between the nonpolar groups of two nicotinic acid molecules (negative contribution to volume); hydrogen bond interactions between the hydrophilic sites (carboxylic acid and N atom of pyridine) of two nicotinic acid molecules , (positive contribution to volume); hydrophilic–hydrophobic interactions between the nonpolar groups and hydrophilic groups of two nicotinic acid molecules (negative contribution to volume); hydrophilic–hydrophilic interactions between water or hydroxyl groups of the d -xylose/ l -arabinose molecule and the hydrophilic sites of nicotinic acid molecules (positive contribution to volume); hydrophilic–hydrophobic interactions between water or hydroxyl groups of the d -xylose/ l -arabinose molecule and the nonpolar groups of the nicotinic acid molecule (negative contribution to volume); hydrophobic–hydrophilic interactions between the nonpolar groups of the d -xylose/ l -arabinose molecule and the hydrophilic sites of the nicotinic acid molecule (negative contribution to volume); and hydrophobic–hydrophobic interactions between the nonpolar groups of the d -xylose/ l -arabinose molecule and the nonpolar groups of the nicotinic acid molecule (negative contribution to volume) …”

“…hydrophobic–hydrophilic interactions between the nonpolar groups of the d -xylose/ l -arabinose molecule and the hydrophilic sites of the nicotinic acid molecule (negative contribution to volume); and…”

“…Fifth, the V ϕ 0 values increase with the increasing molality of carbohydrate solutions; however, the S v values decrease with increasing carbohydrate solution concentration. This may be explained as follows: for one thing, with the increasing molality of the carbohydrate solutions, the number of hydroxyl groups in the aqueous carbohydrate solution also increases, which enhances the hydrogen bond interactions , in the aqueous carbohydrate solution. Also, the enhanced solute–solvent interactions weaken the hydrophilic–hydrophilic interactions between the two nicotinic acid molecules, which reduces the S v value .…”

“…In addition to its applications in the field of medicine, d -xylose is also widely used in the food industry and has great social and economic value. Moreover, l -arabinose is also an important five-carbon carbohydrate . It plays an important role in medicine and culture media because it can serve as the sole carbon source for microbial cultures.…”