Volumetric, Viscometric, and Refractive Index Studies of Drug Nicotinic Acid in Aqueous d-Xylose/l-Arabinose Solutions from 293.15 to 313.15 K: Insights into Solute–Solute and Solute–Solvent Interactions

Abstract

The densities and viscosities of nicotinic acid in pure water and aqueous d-xylose/l-arabinose solutions at temperatures from 293.15 to 313.15 K and the refractive indices of these mixed solutions at 298.15 K were measured under atmospheric pressure. Furthermore, these experimentally measured values of density were used to calculate the apparent molar volume, limiting partial molar volume, and transfer partial molar volume. The Jones–Dole coefficients, namely, viscosity B coefficients, and the variation of B coefficients with temperature were calculated from the experimentally measured values of viscosity according to the Jones–Dole equation. The experimentally measured refractive indices were used to calculate the molar refractions. The above-mentioned parameters and their variation trends are discussed in terms of solute–solute and solute–solvent interactions. The results show that nicotinic acid plays a structure-breaking role in the aqueous carbohydrate solutions studied herein.

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

“…For FA in the aqueous alcohol solutions, n D was measured at a temperature of 298.15 K (Table ). Because there is not much change in R D within the temperature range, the refractive indices were measured at 298.15 K in this work. , The R D values of FA in the aqueous ethanol/1-propanol solutions were calculated from corresponding experimental data using the following Lorentz–Lorenz equation: , R normalD = [ false( n normalD 2 − 1 false) / false( n normalD 2 + 2 false) ] ∑ x i M i / ρ where x i is the molar fraction of FA or solvent and M i is the molecular mass of the i th component of solution.…”

“…The densities of binary solutions (ethanol + water and 1-propanol + water) and ternary solutions (FA + ethanol + water and FA + 1-propanol + water) were measured at different temperatures (293.15, 298.15, 303.15, 308.15, and 313.15 K) and atmospheric pressure with a precision of 1 × 10 –6 g·cm –3 on an Anton Paar DMA 5000 M digital constant temperature liquid densimeter with automatic temperature control with a standard uncertainty of 0.01 K. The instrument is calibrated annually using dry air and the standard liquid supplied by the manufacturer, according to the manufacturer recommendations. Before each measurement, air and water density checks at atmospheric pressure using dry air and freshly prepared double distilled water were also performed to confirm that the measurement precision did not decrease over the measurement period. ,,− All density measurements were performed in triplicate, and corresponding average values were calculated. The standard uncertainty in measured density values was estimated to be 5 × 10 –4 g·cm –3 .…”

“…The inner diameter of the calibrated glass capillary and diameter of the steel ball used in this work were 1.59 and 1.55 mm, respectively, and the density of the steel ball is 7.68 g·cm –3 . The temperature was controlled automatically with a standard uncertainty of 0.02 K. The microviscometer was calibrated with freshly prepared double distilled water at the experimental temperatures before each measurement, as reported in our previous study . The standard uncertainty of viscosity measurements was predicted to be around 0.049 mPa·s.…”

“…The refractive indices of the binary mixtures (ethanol + water and 1-propanol + water) and ternary solutions (FA + ethanol + water and FA + 1-propanol + water) were measured with a model 2 W Abbe refractometer (Shanghai, China). The temperature was controlled with an external constant temperature circulating bath (xt5205-r10-d31, Xutemp Temptech Co., Ltd., Hangzhou, China), and the standard uncertainty was 0.01 K. Before each measurement, the instrument was calibrated with freshly prepared double distilled water at 298.15 K (detailed measurement procedures were reported in our previous studies). ,− , The standard uncertainty of refractive index measurements was predicted to be around 0.0003.…”

“…The temperature was controlled with an external constant temperature circulating bath (xt5205-r10-d31, Xutemp Temptech Co., Ltd., Hangzhou, China), and the standard uncertainty was 0.01 K. Before each measurement, the instrument was calibrated with freshly prepared double distilled water at 298.15 K (detailed measurement procedures were reported in our previous studies). 4,[31][32][33][34][35]37 The standard uncertainty of refractive index measurements was predicted to be around 0.0003.…”