Probable crossing-over in theB blood group system of chickens

Hála, K; Vilhelmová, M; Hartmanová, Jana

doi:10.1007/bf01576942

Cited by 84 publications

(33 citation statements)

References 14 publications

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“…Wattle skin grafts were transplanted onto the backs [8] of 3 to 5-month-old recipients. The grafts were first inspected 7 days after transplantation, the minimum observation time was 98 days, and some grafts were under observation for 190 days.…”

Section: Transplantationmentioning

confidence: 99%

Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

Vilhelmová¹,

Miggiano²,

Pink³

et al. 1977

Eur J Immunol

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In a population of (CB X CC)F1 X WB hybrids, a chicken was found with a presumably recombinant haplotype, BR1, whose antigenic products detectable by hemagglutination contained determinants derived from both parental haplotypes, i.e. B1 (from CB) and B2 (from CC). This recombinant bird and its progeny from different crosses were tested by skin grafting, graft-vs.-host (GVH) and mixed lymphocyte reactions (MLR). The results define two regions of the B system, the B-F and the B-G. The B-F region determined serologically defined antigens, histocompatibility antigens, and controlled the GVH and MLR reactions, while the B-G region was responsible only for synthesis of serologically detectable antigens.

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Section: Transplantationmentioning

confidence: 99%

Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

Vilhelmová¹,

Miggiano²,

Pink³

et al. 1977

Eur J Immunol

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“…The location of the centromere is not known. Calculated genetic distance between Class I and Class IV genes is about .04 cM; this figure is based on the recombination frequency between these two loci (Hala et al, 1976;Koch et al, 1983). All the published and well characterised recombinants in the chicken MHC have occurred between Class I and Class IV genes.…”

Section: Major Histocompatibility Complex Antigens and Recombinant LImentioning

confidence: 99%

Major Histocompatibility Complex and Cell Cooperation

Vainio

Toivanen

1987

Poultry Science

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We have studied the role of major histocompatibility antigens on cell cooperation in the immune response of the chicken. In the 1970's, shortly after the initial discoveries in the mouse, we demonstrated that the T cell-B cell interaction is major histocompatibility complex (MHC)-dependent in the chicken and requires at least one haplotype identity between the collaborating cells. Later, by using MHC-congenic and MHC-recombinant lines, we demonstrated that the T-B cell interaction in antibody response is MHC-restricted, and more precisely, Class II MHC-antigen-restricted. Furthermore, we proved that T-B cell cooperation in splenic germinal center formation is likewise class II MHC antigen-restricted.Recently, we have focused our studies on MHC antigen identity requirements during antigen presentation by macrophages to T cells. In these studies, Class II antigens were found to serve as restriction elements in antigen recognition by T cells. Cytotoxic T cells of the chicken have been shown to be MHC-restricted in their function. Whether Class I or Class II MHC antigens serve as restriction molecules has not yet been determined. In conclusion, it is obvious that the function of the avian immune response is controlled by the polymorphic MHC gene products in the same way as that in the mammalian species.

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“…Ten kinds of antisera were prepared by a previously reported method [9], using RBCs of a red junglefowl and two hybrids against randomly selected chickens from the respective inbred lines. Red junglefowl and the hybrids were used for preparation of antisera because variable MHC IV-coding (B-G antigens) were expected, compared to inbred lines or selected lines of chickens [25].…”

Section: Preparation Of Antisera and Serological Analysismentioning

confidence: 99%