Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

Vilhelmová, M; Miggiano, V.; Pink, J. R. L.; Hála, K; Hartmanová, Jana

doi:10.1002/eji.1830071004

Cited by 20 publications

(6 citation statements)

References 11 publications

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“…The B-F region regulates graft rejection [38] and GVHR [80], the latter being blocked by anti-F antisera [77]. Using the congenic lines CB and CC and recombinant haplotypes B'^i and B^2^ (^jg j-egion was also found to regulate regression of RSV-induced tumours [35].…”

Section: Function Of the Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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The chicken MHC (B complex) initially described by Briles as controlling blood antigens, is now known to be composed of at least three regions, L, F and G. Two of these, F and G, were described on the basis of recombinants found in a study of over 10,000 chickens. On the basis of biochemical, tissue distribution and functional analyses, F corresponds to the murine H-2 K/D regions. The G region is unique to the chicken since the antigenic product is expressed only on erythrocytes and their progenitors. L was identified by serological studies and corresponds to the H-2 I region; the L antigen is expressed predominantly on B lymphocytes, monocytes and 10% of T lymphocytes, and differences in the L region result in variations in immune responsiveness. A number of functional similarities exist between the chicken MHC and that of other species such as regulation of graft rejection, graft-versus-host reaction (GVHR) and mixed lymphocyte reactions (MLR), mitogenic and immune responsiveness and resistance to RNA and DNA virus infection. The chicken MHC also controls the severity of autoimmune disease, as exemplified by the spontaneous thyroiditis of Obese strain (OS) chickens. It differs from mammalian MHC's by having of lower crossing-over frequency and no apparent gene duplication.

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Section: Function Of the Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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“…Also, the weak MLR response between the GSP and GSN/1 inbred lines both fixed for the B allele (B 21 ) may indicate similar MHC antigens related to the MLR response. In chickens, genes controlling MLR as well as GVHR competence have been attributed to the B-L/B-F region of the MHC [40]. It is also educed that there are genetically controlled differences in the magnitudes of MLR response when different reciprocal combinations were tested.…”

Section: Discussionmentioning

confidence: 99%

Histocompatible Chicken Inbred Lines: Homogeneities in the Major Histocompatibility Complex Antigens of the GSP, GSN/1, PNP/DO and BM-C Inbred Lines Assessed by Hemagglutination, Mixed Lymphocyte Reaction and Skin Transplantation

et al. 2007

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“…Control of MLR was demonstrated by Miggiano et al [26] and Schou [31]. The controlling genes have been mapped to the region encoding B-L and B-F antigens [35,37].…”

Section: Involvement Of B-l In Mixed Lymphocyte Reactions and Graft-vmentioning

confidence: 96%

B‐L Antigens (Ia‐like Antigens) of the Chicken Major Histocompatibility Complex

1981

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This paper reviews the present knowledge of B-L antigens encoded by the chicken B complex as regards to the following aspects: (1) identification and cellular expression, (2) structural studies, (3) evidence for two distinct populations of B-L antigens, (4) mapping of B-L loci of the B complex, (5) B-L and immune response, and (6) the role of the B-L antigens for the control of mixed lymphocyte reactions (MLR) and graft-versus-host (GVH) reactions. It is concluded that B-L antigens of the chicken exhibit extensive homology with mammalian Ia antigens. A genetic map of the B complex is presented.

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Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

Cited by 20 publications

References 11 publications

Chicken Major Histocompatibility Complex and Disease

Chicken Major Histocompatibility Complex and Disease

Histocompatible Chicken Inbred Lines: Homogeneities in the Major Histocompatibility Complex Antigens of the GSP, GSN/1, PNP/DO and BM-C Inbred Lines Assessed by Hemagglutination, Mixed Lymphocyte Reaction and Skin Transplantation

B‐L Antigens (Ia‐like Antigens) of the Chicken Major Histocompatibility Complex

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