ProAir<sup>®</sup> HFA Delivers Warmer, Lower-Impact, Longer-Duration Plumes Containing Higher Fine Particle Dose Than Ventolin<sup>®</sup> HFA

McCabe, Jacquelyn Cruz; Koppenhagen, Franciscus; Blair, Julian M.; Zeng, Xian-Ming

doi:10.1089/jamp.2011.0891

Cited by 20 publications

(12 citation statements)

References 12 publications

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“…The aerosol characteristics of the pMDI alone of Ventolin and ProAir are similar to those reported by McCabe et al 9 They reported an MMAD/GSD/fine-particle dose (calculated as mass for percentage Ͻ 5 m) for Ventolin alone of 2.4 m/2.0/26 g, compared with our findings of 2.39 m/1.41/29.3 g. Similarly, they reported MMAD/GSD/fine-particle dose for ProAir alone of 2.3 m/1.6/53 g, and we measured 2.21 m/1.43/42.9 g.…”

Section: Discussionsupporting

confidence: 86%

“…We speculate that the difference in magnitude seen between ProAir and the others is because its aerosol velocity is slower than the others. 7,9 Hautman et al 7 limited the particle size distribution analysis to fine-particle mass. Our study provides a more complete description of the aerosols and also introduces the effect of delay between actuation and measurement as novel data.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors have reported differences in the aerosol characteristics of different brands; therefore, evaluating all available brands is also relevant. 7,9 In this study, we compared the aerosol characteristics of 3 different brands of albuterol hydrofluoroalkane (HFA) pMDI alone, with a valved holding chamber, and with a valved holding chamber introducing a 10-s delay between actuation and inhalation. We hypothesized that (1) there would be differences in the characteristics of the aerosol generated by each brand of inhaler actuated at different time intervals, (2) the use of a valved holding chamber would eliminate those differences, and (3) the introduction of a 10-s delay between actuation and measurement could change aerosol characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Berlinski

Pennington

2017

Respir Care

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BACKGROUND: Albuterol hydrofluoroalkane (HFA) either alone or with a valved holding chamber is used to treat bronchoconstriction. Delays between actuation and inhalation are common. Currently, the recommended interval between actuations of an albuterol HFA is 60 s. Using a shorter interval when multiple actuations are ordered will improve productivity in the hospital setting. METHODS: We studied aerosol characteristics of albuterol HFA (Ventolin, ProAir, and Proventil) with a cascade impactor calibrated at 30 L/min. We studied pressurized metered-dose inhalers (pMDI) alone, coupled to a nonelectrostatic valved holding chamber, and coupled to the valved holding chamber but introducing a 10-s delay between actuation and measurement. We tested intervals between actuations of 60, 30, and 15 s (not for delay scenario). The variable of most interest was fine-particle mass. Albuterol was measured by spectrophotometer (276 nm). RESULTS: Variations in fine-particle mass from 60-s values were < 15% for Ventolin and ProAir for all conditions tested and for Proventil with a valved holding chamber. Variations in fine-particle mass from 60-s values were > 15% for Proventil (pMDI alone with a 30-s interval and pMDI/valved holding chamber with delay and a 30-s interval). Adding a valved holding chamber increased fine-particle mass for all brands (ProAir 7-12%, Ventolin 26 -35%, and Proventil 44 -47%). The introduction of a 10-s delay reduced fine-particle mass for all brands (ProAir 34 -39%, Ventolin 39 -42%, and Proventil 27-32%). Comparison of fine-particle mass among brands showed that Proventil was > ProAir > Ventolin. CONCLUSIONS: Decreasing the interval between actuations from 60 to 30 and 15 s does not seem to affect the aerosol characteristics of ProAir and Ventolin. Although some changes were noticed for Proventil, the pMDI outperformed Ventolin that had the lowest fineparticle mass. The use of a valved holding chamber increased fine-particle mass, but introducing a 10-s delay between actuation and inhalation significantly reduced fine-particle mass.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Berlinski

Pennington

2017

Respir Care

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“…The FPF for mannitol and CSLA microparticles was determined to be 49% and 46%, respectively, which is excellent, falling within those of commercial HFA-based pMDIs for small-molecule therapeutics (30–55% on average) 65,71 even though no optimization was attempted in our case. It is worth noticing that FPFs for both formulations were not significantly different ( n = 2, One-Way ANOVA followed by Tukey’s posthoc test, p value <0.05).…”

Section: Resultsmentioning

confidence: 48%

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

et al. 2014

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Small interfering RNA (siRNA)-based therapies have great promise in the treatment of a number of prevalent pulmonary disorders including lung cancer, asthma and cystic fibrosis. However, progress in this area has been hindered due to the lack of carriers that can efficiently deliver siRNA to lung epithelial cells, and also due to challenges in developing oral inhalation (OI) formulations for the regional administration of siRNA and their carriers to the lungs. In this work we report the ability of generation four, amine-terminated poly(amidoamine) (PAMAM) dendrimer (G4NH2)–siRNA complexes (dendriplexes) to silence the enhanced green fluorescent protein (eGFP) gene on A549 lung alveolar epithelial cells stably expressing eGFP. We also report the formulation of the dendriplexes and their aerosol characteristics in propellant-based portable OI devices. The size and gene silencing ability of the dendriplexes was seen not to be a strong function of the N/P ratio. Silencing efficiencies of up to 40% are reported. Stable dispersions of the dendriplexes encapsulated in mannitol and also in a biodegradable and water-soluble co-oligomer were prepared in hydrofluoroalkane (HFA)-based pressurized metered-dose inhalers (pMDIs). Their aerosol characteristics were very favorable, and conducive to deep lung deposition, with respirable fractions of up to 77%. Importantly, siRNA formulated as dendriplexes in pMDIs was shown to keep its integrity after the particle preparation processes, and also after long-term exposures to HFA. The relevance of this study stems from the fact that this is the first work to report the formulation of inhalable siRNA with aerosol properties suitable to deep lung deposition using pMDIs devices that are the least expensive and most widely used portable inhalers. This study is relevant because, also for the first time, it shows that siRNA–G4NH2 dendriplexes can efficiently target lung alveolar epithelial A549 cells and silence genes even after siRNA has been exposed to the propellant environment.

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“…The median mass aerodynamic diameter of the aerosols generated ranges from 2.3 to 3.1 m. The jet and vibrating mesh nebulizers have label specifications of 2.7 and 3.1 m, respectively, whereas the pMDI has a reported median mass aerodynamic diameter of 2.3 m. 19 The jet and vibrating mesh nebulizers were filled with albuterol sulfate (2.5 mg/3 mL, Nephron Pharmaceuticals, Orlando, Florida). The jet nebulizer was operated with oxygen at 8 L/min using a calibrated flow meter.…”

Section: Types and Operation Of Aerosol Devicesmentioning

confidence: 99%

Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model

et al. 2015

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BACKGROUND: This study was conducted to compare the efficiency of jet nebulizers, vibrating mesh nebulizers, and pressurized metered-dose inhalers (pMDI) during assisted and unassisted administration techniques using a simulated spontaneously breathing pediatric model with a tracheostomy tube (TT). METHODS: An in vitro breathing model consisting of an uncuffed TT (4.5-mm inner diameter) was attached to a collecting filter (Respirgard) connected to a dualchamber test lung and a ventilator (Hamilton Medical) to simulate breathing parameters of a 2-y-old child (breathing frequency, 25 breaths/min; tidal volume, 150 mL; inspiratory time, 0.8 s; peak inspiratory flow, 20 L/min). Albuterol sulfate was administered using a jet nebulizer (MicroMist, 2.5 mg/3 mL), vibrating mesh nebulizer (Aeroneb Solo, 2.5 mg/3 mL), and pMDI (ProAir HFA, 432 g). Each device was tested 5 times with an unassisted technique (direct administration of aerosols with simulated spontaneous breathing) and with an assisted technique (using a manual resuscitation bag in conjunction with an aerosol device and synchronized with inspiration). Drug collected on the filter was analyzed by spectrophotometry. RESULTS: With the unassisted technique, the pMDI had the highest inhaled mass percent (IM%, 47.15 ؎ 7.82%), followed by the vibrating mesh nebulizer (19.77 ؎ 2.99%) and the jet nebulizer (5.88 ؎ 0.77%, P ‫؍‬ .002). IM was greater with the vibrating mesh nebulizer (0.49 ؎ .07 mg) than with the pMDI (0.20 ؎ 0.03 mg) and the jet nebulizer (0.15 ؎ 0.01 mg, P ‫؍‬ .007). The trend of lower deposition with the assisted versus unassisted technique was not significant for the jet nebulizer (P ‫؍‬ .46), vibrating mesh nebulizer (P ‫؍‬ .19), and pMDI (P ‫؍‬ .64). CONCLUSIONS: In this in vitro pediatric breathing model with a TT, the pMDI delivered the highest IM%, whereas the vibrating mesh nebulizer delivered the highest IM. The jet nebulizer was the least efficient device. Delivery efficiency was similar with unassisted and assisted administration techniques.

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ProAir^® HFA Delivers Warmer, Lower-Impact, Longer-Duration Plumes Containing Higher Fine Particle Dose Than Ventolin^® HFA

Abstract: The ProAir(®) HFA delivers a warmer, lower-impact, and longer-lasting plume compared with Ventolin(®) HFA, which may provide a more consistent, comfortable experience for patients using a pMDI. ProAir(®) HFA produces higher fine particle dose than Ventolin(®) HFA.

Cited by 20 publications

References 12 publications

Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model

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ProAir® HFA Delivers Warmer, Lower-Impact, Longer-Duration Plumes Containing Higher Fine Particle Dose Than Ventolin® HFA

Abstract: The ProAir(®) HFA delivers a warmer, lower-impact, and longer-lasting plume compared with Ventolin(®) HFA, which may provide a more consistent, comfortable experience for patients using a pMDI. ProAir(®) HFA produces higher fine particle dose than Ventolin(®) HFA.

Cited by 20 publications

References 12 publications

Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Effect of Interval Between Actuations of Albuterol Hydrofluoroalkane Pressurized Metered-Dose Inhalers on Their Aerosol Characteristics

Poly(amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for siRNA Delivery to the Lung Epithelium

Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Tracheostomy Model

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Product

Resources

About

ProAir^® HFA Delivers Warmer, Lower-Impact, Longer-Duration Plumes Containing Higher Fine Particle Dose Than Ventolin^® HFA