Proadrenomedullin as a prognostic biomarker for critically-ill septic children

Ghobrial, Emad E.; Khorshied, Mervat M.; Adly, Sally B; Aziz, Miriam Magdy

doi:10.21203/rs.2.22810/v1

Cited by 2 publications

(3 citation statements)

References 14 publications

(17 reference statements)

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“…In addition, ADM levels increase in hepatic and renal failure (Abd Elmouttaleb et al, 2016). Lipopolysaccharides that cause sepsis (Garayoa et al, 2000), proinflammatory cytokines (Ghobrial et al, 2020), hypoxia in sepsis, oxidative stress, and inflammation increase ADM synthesis (Simon et al, 2016;Jordan et al, 2014;Fahmey et al, 2018;Garazzino et al, 2019). Also, ADM has antimicrobial (Garazzino et al, 2019) and anti-inflammatory properties (Akpınar et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

Sezer,

Gökce

2024

J Hellenic Vet Med Soc

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This study aimed to determine the changes in biochemical and hematological parameters and the expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM 1) and mid-regional-pro-adrenomedullin (MR-Pro-ADM) on myeloid cells during treatment in calves with neonatal sepsis. The study group comprised 21 calves, aged 1–16 days, that fit the sepsis criteria. The control group comprised 10 healthy calves of the same age. The clinical examinations of the calves in the study group were performed at certain hours before the treatment (hour 0) and during the treatment (12th, 24th, 48th, and 72nd hours). The blood samples were taken from the vena jugularis before and during treatment from the sick calves and once from the healthy calves. The sTREM-1 levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows 59.17±2.58 ng/L, 57.07±1.65 ng/L, 57.27±2.07 ng/L, 56.64±1.97 ng/L, 57.58±2.18 ng/L and 75.60±2.57 ng/L,39 respectively. The MR-Pro-ADM levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows; 117.88±7.75 ng/L, 113.63±5.18 ng/L, 109.97±5.25 ng/L, 114.50±5.35 ng/L, 111,84±5.63 ng/L,65.31±2.81 ng/L, respectively. The serum MR-Pro-ADM levels in calves with sepsis were significantly higher than those in the control group before and during treatment (P < 0.05). Also, the serum sTREM-1 level was significantly lower before and after treatment in the sepsis group compared with the control group (P < 0.05). MR-Pro-ADM and sTREM-1 were more important, especially in terms of diagnosis in evaluating calves with neonatal sepsis.

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Section: Discussionmentioning

confidence: 99%

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

Sezer,

Gökce

2024

J Hellenic Vet Med Soc

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“…Cases characterized by reduced glomerular filtration and renal failure have also been reported to be associated with increased ADM levels (Jordan et al 2014). Furthermore, the glucocorticoid hormone, lipopolysaccharides found in the cell wall of Gram-negative bacteria (Garayoa et al 2000), cytokines (Ghobrial et al 2020), anoxia, and inflammation-induced oxidative stress also cause increased ADM levels (Fahmey et al 2018, Garazzino et al 2019. ADM is known to have antibacterial and anti-inflammatory effects (Akpınar et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…ADM is localized to the surface of the epithelium lining the respiratory tract (Valenzulea-Sanchez et al 2016). In cases of hypoxia, oxidative stress and inflammation, which are induced by lipopolysaccharides (Garayoa et al 2000) and cytokines such as TNF-α and IL-1 (Ghobrial et al 2020), ADM synthesis has been determined to increase (Fahmey et al 2018). It is not possible to measure blood adrenomedullin levels as this peptide hormone rapidly binds to its carrier receptors, has a short half-life and is rapidly metabolized (Geven et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

SEZER

Akyüz

Merhan

et al. 2023

Kocatepe Veterinary Journal

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This study was aimed at the determination of the serum levels of two inflammatory biomarkers, namely, mid-regional pro-adrenomedullin and soluble triggering receptor expressed on myeloid cells, as well as some biochemical and hematological parameters in cattle diagnosed with pneumonia. For this purpose, 40 patient female cattle, which were aged 2-7 years and displayed coughing, dyspnea, nasal discharge, anorexia and abdominal respiration, and 15 healthy female cattle within the same age range, were evaluated. The diseased cattle underwent clinical and radiological examinations and were sampled for blood prior to receiving treatment. The healthy subjects also underwent clinical examination and were sampled for blood once. The blood samples were used for biochemical and hematological measurements. The healthy and diseased cattle showed statistically significant differences for the serum levels of mid-regional pro-adrenomedullin and soluble triggering receptor expressed on myeloid cells (P

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Proadrenomedullin as a prognostic biomarker for critically-ill septic children

Cited by 2 publications

References 14 publications

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

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