Pro-Oxidant Natural Products as Anticancer Agents

Martı́n-Cordero, Carmen; León‐González, Antonio J.; Calderón-Montaño, José Manuel; Burgos-Morón, Estefanía; López‐Lázaro, Miguel

doi:10.2174/138945012802009044

Cited by 151 publications

(95 citation statements)

References 414 publications

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“…The contradiction in curcumin's role of antioxidant and prooxidant could be reconciled by curcumin'sability to target malignant cells selectively (Zanotto-Fibno et al, 2012). Cancer cells are consistently under oxidative stress and more vulnerable to ROS-induced cytotoxity than normal cells (Martin-Cordero et al, 2012). Thus, curcumin at a specifically low concentration would induce apoptosis of malignant cells rather than normal ones.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway

Li²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Curcumin can inhibit proliferation of liver cancer cells by inducing apoptosis, but the specific signaling pathways involved are not completely clear. Here, we report that curcumin inhibited proliferation of MHCC97H liver cancer cells by induction of apoptosis in a concentration dependent manner via stimulating intracellular reactive oxygen species (ROS) generation. Also, we showed that increased intracellular ROS formation activated the TLR-4/MyD-88 signaling pathway, resulting in activation of caspase-8 and caspase-3, which eventually led to apoptosis in MHCC97H cells. These results showed that as an prooxidant, curcumin exerts anti-cancer effects by inducing apoptosis via the TLR-4/MyD-88 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway

Li²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Medicinal plants represent a vital source of novel bioactive compounds that might be used as cancer chemotherapeutic agents (Martin-Cordero et al, 2012;Siu, 2011). Accordingly, Persea americana Mill var.…”

Section: Introductionmentioning

confidence: 99%

Pro-apoptotic effect ofPersea americanavar.Hass(avocado) on Jurkat lymphoblastic leukemia cells

Bonilla-Porras

Salazar-Ospina

Jiménez-Del-Río

et al. 2013

Pharmaceutical Biology

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Context: Therapy for leukemia has a limited efficacy. There is a need to search for alternative anti-leukemia therapies. Persea americana Mill var. Hass (Lauraceae) is a tropical fruit (avocado) that might be used against cancer. Objective: To investigate whether P. americana induces death in Jurkat lymphoblastic leukemia cells. Materials and methods: Four ethanol extracts (0.1, 0.5, 1, 2 and 5 mg/mL) from avocado fruit (endocarp, whole seed, seed and leaves) were analyzed against Jurkat cells. Hydrogen peroxide generation by oxidation of 2 0 ,7 0 -dichlorodihydrofluorescein diacetate to the fluorescent compound 2 0 ,7 0 -dichlorfluorescein assay, acridine orange/ethidium bromide staining, flow cytometry analysis of annexin-V/7-amino-actinomycin, mitochondrial membrane potential and immunocytochemistry detection of transcription factor p53, caspase-3 and apoptosis-inducing factor (AIF) were evaluated. Results: Endocarp, seed, whole seed, and leaf (0.1 mg/mL) extracts induced significant apoptosis in Jurkat cells (p50.001) in an oxidative stress-dependent fashion via mitochondrial membrane depolarization (52-87%), activation of transcription factor p53 (6.3-25.4%), protease caspase-3 (8.3-20%) and predominance of AIF reactivity (20.6-36%) in all extracts. Similar results were obtained with 0.5 mg/mL extracts. However, extract !1 mg/mL concentration induced necrosis (100%). Conclusions: P. americana extracts function as a pro-apoptotic compound. Leukemic cells are eliminated through an oxidative stress mechanism. This study contributes to the understanding of the molecular mechanism of the avocado and its therapeutic action on leukemia.

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“…Evidence suggests that reactive oxygen species (ROS) have an important role in the anticancer activity of several clinically useful drugs (20,21). To test whether the ROS generation participates in AzGalp-induced cytotoxicity, A549 cells were exposed to this compound in the presence or absence of the antioxidants catalase, N-acetylcisteine (NAC) and the superoxide dismutase mimetic MnTMPyP for 48 h and cell proliferation was determined with the MTT assay ( Figure 4A-C).…”

Section: Evaluation Of Other Possible Mechanisms Involved In the Selementioning

confidence: 99%

<em></em><em>In Vitro</em> Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside

Burgos-Morón¹,

N²,

Ml³

et al. 2018

Preprint

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We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-β-D-galactopyranoside (AzGalp) as the most promising compound. In this article, we explore possible mechanisms involved in the cytotoxicity of this aziridine and evaluate its selective anticancer activity using cancer cells and normal cells from a variety of tissues. Our data show that AzGalp induces DNA damage (detected with the comet assay). Cells deficient in the DNA repair pathway nucleotide excision repair (NER) were hypersensitive to the cytotoxicity of this compound. These results suggest that AzGalp induces bulky DNA adducts, and that cancer cells lacking a functional NER pathway may be particularly vulnerable to the anticancer effects of this aziridine. Several experiments revealed that neither the generation of oxidative stress nor the inhibition of glycolysis played a significant role in the cytotoxicity of AzGalp. The combinations of AzGalp with either oxaliplatin or 5-fluorouracil slightly improved the ability of both anticancer drugs to selectively kill cancer cells. AzGalp also displayed selective cytotoxicity against a panel of malignant cells versus normal cells; the highest selectivity was observed for two acute promyelocytic leukemia cell lines. Additional preclinical studies are necessary to evaluate the anticancer potential of AzGalp.

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Pro-Oxidant Natural Products as Anticancer Agents

Cited by 151 publications

References 414 publications

Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway

Curcumin Inhibits MHCC97H Liver Cancer Cells by Activating ROS/TLR-4/Caspase Signaling Pathway

Pro-apoptotic effect ofPersea americanavar.Hass(avocado) on Jurkat lymphoblastic leukemia cells

<em></em><em>In Vitro</em> Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside

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