Pro-Inflammatory Phenotype of Perivascular Astrocytes and Cd133+ Endothelial Progenitor Cells in Murine Model of Alzheimer’s Disease

CHERNYKH, ANATOLIY I.; KOMLEVA, YULIYA K.; Gorina, Yana V.; Lopatina, Olga; PASCHENKO, SVETLANA I.; Салмина, А. Б.

doi:10.23946/2500-0764-2018-3-1-6-15

Cited by 8 publications

(3 citation statements)

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“…Our own data have shown the protective phenotype of Nlrp3 knockout mice in the development of brain IR ( Chernykh et al, 2018 ). Using an experimental approach to modeling AD, we investigated new molecular mechanisms of insulin signaling dysregulation in the amygdala in association with neuroinflammation and emotional disorders.…”

Section: Metabolic Hallmarks Of Aging and Their Role In The Cognitivementioning

confidence: 93%

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

et al. 2021

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Over the past decades, the human life span has dramatically increased, and therefore, a steady increase in diseases associated with age (such as Alzheimer’s disease and Parkinson’s disease) is expected. In these neurodegenerative diseases, there is a cognitive decline and memory loss, which accompany increased systemic inflammation, the inflamm-aging, and the insulin resistance. Despite numerous studies of age-related pathologies, data on the contribution of brain insulin resistance and innate immunity components to aging are insufficient. Recently, much research has been focused on the consequences of nutrients and adiposity- and nutrient-related signals in brain aging and cognitive decline. Moreover, given the role of metainflammation in neurodegeneration, lifestyle interventions such as calorie restriction may be an effective way to break the vicious cycle of metainflammation and have a role in social behavior. The various effects of calorie restriction on metainflammation, insulin resistance, and neurodegeneration have been described. Less attention has been paid to the social determinants of aging and the possible mechanism by which calorie restriction might influence social behavior. The purpose of this review is to discuss current knowledge in the interdisciplinary field of geroscience—immunosenescence, inflamm-aging, and metainflammation—which makes a significant contribution to aging. A substantial part of the review is devoted to frontiers in the brain insulin resistance in relation to neuroinflammation. In addition, we summarize new data on potential mechanisms of calorie restriction that influence as a lifestyle intervention on the social brain. This knowledge can be used to initiate successful aging and slow the onset of neurodegenerative diseases.

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Section: Metabolic Hallmarks Of Aging and Their Role In The Cognitivementioning

confidence: 93%

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

et al. 2021

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“…Microglia activated by high-mobility group box 1 (HMGB1) secrete TNF-α, IL-1β, reactive oxygen species (ROS), and numerous proinfl ammatory cytokines [11,12], which initiate infl ammatory reactions in the brain in response to harmful stimuli [13,14]. Increases in the number of activated glial cells and the concentrations of a number of cytokines (such as TNF-α) in the hippocampus, cerebral cortex, substantia nigra, and striatum are associated with decreases in hippocampal volume and cognitive dysfunction due to the neurodegenerative process [15].…”

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confidence: 99%

“…Apart from microglia, damaged astrocytes and pericytes can produce proinfl ammatory cytokines [15]. Activated astrocytes form a glial scar, limiting the potential for recovery of damaged axons.…”

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confidence: 99%

SARS-CoV-2 (COVID-19) as a Predictor of Neuroinflammation and Neurodegeneration: Potential Treatment Strategies

Путилина

Grishin

2021

Neurosci Behav Physi

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The SARS-CoV-2 (COVID-19) pandemic has attracted attention to the challenge of neuroinflammation as an unavoidable component of viral infections. Acute neuroinflammatory responses include activation of resident tissue macrophages in the CNS followed by release of a variety of cytokines and chemokines associated with activation of oxidative stress and delayed neuron damage. This makes the search for treatments with indirect anti-inflammatory properties relevant. From this point of view, attention is focused on further study of the treatment of patients with COVID-19 with dipyridamole (Curantil) which, having antiviral and anti-inflammatory effects, can inhibit acute inflammatory activity and progression of fibrosis, is a drug with potential, especially among patients with early increases in the D-dimer concentration and severe signs of microangiopathy.

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Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer’s Type Neurodegeneration

et al. 2021

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Pro-Inflammatory Phenotype of Perivascular Astrocytes and Cd133+ Endothelial Progenitor Cells in Murine Model of Alzheimer’s Disease

Abstract: 6 стр. 16 стр. 22 стр. 30стр. 36 стр. 42 стр. 51 стр.

Cited by 8 publications

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Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration

SARS-CoV-2 (COVID-19) as a Predictor of Neuroinflammation and Neurodegeneration: Potential Treatment Strategies

Expression of NLRP3 Inflammasomes in Neurogenic Niche Contributes to the Effect of Spatial Learning in Physiological Conditions but Not in Alzheimer’s Type Neurodegeneration

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