Pro- and Synbiotics to Prevent Sepsis in Major Surgery and Severe Emergencies

Bengmark, S

doi:10.3390/nu4020091

Cited by 19 publications

(16 citation statements)

References 92 publications

(104 reference statements)

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“…Sepsis is a life-threatening complication of infection and characterized by physiologic, pathologic, and biochemical abnormalities [1, 2]. It is the tenth-most-common cause of death globally [3] and the most common cause of death in patients with infections, especially when sepsis is not identified and treated promptly. Early treatment of sepsis improves patients’ mortality and outcome [1].…”

Section: Introductionmentioning

confidence: 99%

Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis

Liu

Meng

et al. 2019

Scand J Trauma Resusc Emerg Med

210

169

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Background Sepsis is a common critical condition caused by the body’s overwhelming response to certain infective agents. Many biomarkers, including the serum lactate level, have been used for sepsis diagnosis and guiding treatment. Recently, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) recommended the Sequential Organ Failure Assessment (SOFA) and the quick SOFA (qSOFA) rather than lactate for screening sepsis and assess prognosis. Here, we aim to explore and compare the prognostic accuracy of the lactate level, the SOFA score and the qSOFA score for mortality in septic patients using the public Medical Information Mart for Intensive Care III database (MIMIC III). Methods The baseline characteristics, laboratory test results and outcomes for sepsis patients were retrieved from MIMIC III. Survival was analysed by the Kaplan-Meier method. Univariate and multivariate analysis was performed to identify predictors of prognosis. Receiver operating characteristic curve (ROC) analysis was conducted to compare lactate with SOFA and qSOFA scores. Results A total of 3713 cases were initially identified. The analysis cohort included 1865 patients. The 24-h average lactate levels and the worst scores during the first 24 h of ICU admission were collected. Patients in the higher lactate group had higher mortality than those in the lower lactate group. Lactate was an independent predictor of sepsis prognosis. The AUROC of lactate (AUROC, 0.664 [95% CI, 0.639–0.689]) was significantly higher than that of qSOFA (AUROC, 0.547 [95% CI, 0.521–0.574]), and it was similar to the AUROC of SOFA (AUROC, 0.686 [95% CI, 0.661–0.710]). But the timing of lactate relative to SOFA and qSOFA scores was inconsistent. Conclusion Lactate is an independent prognostic predictor of mortality for patients with sepsis. It has superior discriminative power to qSOFA, and shows discriminative ability similar to that of SOFA. Electronic supplementary material The online version of this article (10.1186/s13049-019-0609-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis

Liu

Meng

et al. 2019

Scand J Trauma Resusc Emerg Med

210

169

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“…Using a synbiotic helps the growth of host microorganisms in the gut with probiotic properties (Furrie et al, 2005;Picaud et al, 2010;Roberfroid, 1998). The synbiotic concept combines efficacious probiotic strains with specific prebiotic compounds in a single product (Zhang et al, 2010;Fotiadis et al, 2008;Bengmark, 2012;Martin et al, 2012;Ghosh, 2012). The synbiotic concept combines efficacious probiotic strains with specific prebiotic compounds in a single product (Zhang et al, 2010;Fotiadis et al, 2008;Bengmark, 2012;Martin et al, 2012;Ghosh, 2012).…”

Section: Treatment and Synbioticsmentioning

confidence: 99%

Synbiotics and Infantile Acute Gastroenteritis

Gündoğdu

2016

Probiotics, Prebiotics, and Synbiotics

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“…Sinbiotik juga menurunkan komplikasi infeksi pasca operasi pada berbagai kondisi bedah. [9][10][11][12][13][14][15][16] Melalui perannya dalam memodulasi sistem imun, sinbiotik diperkirakan berpotensi dalam menurunkan respon inflamasi pasca operasi pada anak appendisitis komplikata, yang dicerminkan oleh penurunan CRP, sehingga diharapkan dapat menurunkan kejadian komplikasi infeksi pasca operasi. Tujuan penelitian ini adalah mempelajari perbedaan penurunan kadar CRP serum pasca operasi antara pemberian sinbiotik dan plasebo pada anak appendisitis komplikata.…”

Section: Pendahuluanunclassified

Pengaruh Sinbiotik terhadap Penurunan Kadar C-Reactive Protein Serum Pasca operasi pada Anak Appendisitis Komplikata

Indriasari¹,

Nawas²,

Kusmayadi³

et al. 2014

jibi-ikabi

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Background. Appendicitis is the most common cause of acute abdomen in children. Complicated appendicitis due to perforation associated with high morbidity. Several perioperative conditions fascilitated systemic inflammation and postoperative infectious complication. Synbiotic has a potential effect on reducing inflammatory response which reflected with lower serum c-reactive protein (CRP) level, so that the infectious complication could be avoided. Aim.This study aimed to observe the effect of synbiotic on postoperative serum CRP level reduction in children with complicated appendicitis. Method. A randomized double blind study was done in 26 children with com- plicated appendicitis. The subjects were divided into synbiotic and placebo groups. Synbiotic was given 1 time preoperatively and continued 5 days afer surgery. Serum CRP level were examined preoperatively (CRP 0), postoperative day 1 (CRP 1), and 6 (CRP 6). Statistical analysis was done with Independent-t test (p<0,05 considered significan)t. Result. The mean age of the patients was 9,85 years. The onset of abdominal pain was 3,92 days. The mean reduction of CRP 0 –CRP 6 between synbiotic and placebo group was 65,21% ± 31,37 SD vs 78,29% ± 12,39 SD, p=0,073; and the mean reduction of CRP 1–CRP 6 was 73,54% ± 22,04 vs 74,56% ±17,58, p=0,897. Wound infection was lower in synbiotic group (7,69% vs 38,46%). Conclusion. There was no difference in postoperative serum CRP level reduction between synbiotic therapy and placebo in children with compli- cated appendicitis

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Pro- and Synbiotics to Prevent Sepsis in Major Surgery and Severe Emergencies

Cited by 19 publications

References 92 publications

Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis

Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis

Synbiotics and Infantile Acute Gastroenteritis

Pengaruh Sinbiotik terhadap Penurunan Kadar C-Reactive Protein Serum Pasca operasi pada Anak Appendisitis Komplikata

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